ID V8P1R2_OPHHA Unreviewed; 828 AA.
AC V8P1R2;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 22-FEB-2023, entry version 26.
DE SubName: Full=Dystrobrevin alpha {ECO:0000313|EMBL:ETE68126.1};
DE Flags: Fragment;
GN Name=DTNA {ECO:0000313|EMBL:ETE68126.1};
GN ORFNames=L345_06083 {ECO:0000313|EMBL:ETE68126.1};
OS Ophiophagus hannah (King cobra) (Naja hannah).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE68126.1, ECO:0000313|Proteomes:UP000018936};
RN [1] {ECO:0000313|EMBL:ETE68126.1, ECO:0000313|Proteomes:UP000018936}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Blood {ECO:0000313|EMBL:ETE68126.1};
RX PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., Dirks R.P.,
RA Spaink H.P., Duboule D., McGlinn E., Kini R.M., Richardson M.K.;
RT "The king cobra genome reveals dynamic gene evolution and adaptation in the
RT snake venom system.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETE68126.1}.
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DR EMBL; AZIM01001093; ETE68126.1; -; Genomic_DNA.
DR AlphaFoldDB; V8P1R2; -.
DR Proteomes; UP000018936; Unassembled WGS sequence.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd16244; EFh_DTN; 1.
DR CDD; cd02334; ZZ_dystrophin; 1.
DR Gene3D; 3.30.60.90; -; 1.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR015153; EF-hand_dom_typ1.
DR InterPro; IPR015154; EF-hand_dom_typ2.
DR InterPro; IPR000433; Znf_ZZ.
DR InterPro; IPR043145; Znf_ZZ_sf.
DR PANTHER; PTHR12268:SF22; DYSTROBREVIN BETA; 1.
DR PANTHER; PTHR12268; E3 UBIQUITIN-PROTEIN LIGASE KCMF1; 1.
DR Pfam; PF09068; EF-hand_2; 1.
DR Pfam; PF09069; EF-hand_3; 1.
DR Pfam; PF00569; ZZ; 1.
DR SMART; SM00291; ZnF_ZZ; 1.
DR SUPFAM; SSF47473; EF-hand; 2.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS01357; ZF_ZZ_1; 1.
DR PROSITE; PS50135; ZF_ZZ_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000018936};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00228}.
FT DOMAIN 254..310
FT /note="ZZ-type"
FT /evidence="ECO:0000259|PROSITE:PS50135"
FT REGION 580..618
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 686..708
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 488..568
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 600..615
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ETE68126.1"
SQ SEQUENCE 828 AA; 94771 MW; B4A2E25FB6093D0B CRC64;
MAAVMCQWER EASMELMIEE SGKRRRTMAE KRQLFMEMRA QNFDVIRLST YRTACKLRFV
QKRCNLHLVD IWNMIEAFRD NGLNTLDHNT EINVSRLETI ISSIYYQLNK RLPSTHQISV
EQSISLLLNF MIAAYDRQRR SWKIDSVFHK GNVGNYVWWK NSGQAKIFSQ MSDSNGLMIF
SKFDQFLREV LKLPTAVFEG PSFGYTENSV RTCFPQQKKV TLNVFLDTLM ADPPPQCLVW
LPLMHRLAHV ENVFHPVECS YCRCESMMGF RYRCQQCHNY QLCQNCFWRG HANGPHSNQH
QMKEHSSWKS PAKKLSHAIS KSLGCVPTRD PPHPVYPEQP EKPLDLAHIV PSRPLVNMND
AMVTHETPAY LSHCCLLTFT YVNYYFLIML YSSNNLHYFI ASSSFLLSFA SFAFNIPRLQ
QSLAPSDGLS DEHVLIAAYV SQLQSSTRSV LDSPSRLDEE HRLIARYAAR LAAEAGNVTR
PPIDLGFNFD ANKQQRQLIA ELENKNREIL QEIQRLRLEH EQASQPTPEK AQQNPTLLAE
LRLLRQRKDE LEQRMSALQE SRRELMVQLE GLMKLLKAQA AGSPHTSPTH GAGRSMPMPV
RSTSAGSTPT HVPQDSLTGV GGDVQEAFAQ GTRRNLRNDL LVAADSITNT MSYLVKELHS
VGKLLNVFAE PIQAHLVSVD SRTAAIGSNR GEEGGEEEEE EDKMQNGKDR ETYNVHHFKH
KIKMIFGFTK FSFVSCRLNK KKNLDQPEIE ILFGGYLKGD GMGEGLGMRC TWHVYAANRK
LFEASFSVFG SLQKNFDKQV SYEILYVLIQ VFSANWTEPH LCFNEKAF
//
