ID V8P215_OPHHA Unreviewed; 521 AA.
AC V8P215;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Double-strand-break repair protein rad21-like protein {ECO:0000313|EMBL:ETE68539.1};
GN Name=RAD21 {ECO:0000313|EMBL:ETE68539.1};
GN ORFNames=L345_05659 {ECO:0000313|EMBL:ETE68539.1};
OS Ophiophagus hannah (King cobra) (Naja hannah).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE68539.1, ECO:0000313|Proteomes:UP000018936};
RN [1] {ECO:0000313|EMBL:ETE68539.1, ECO:0000313|Proteomes:UP000018936}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Blood {ECO:0000313|EMBL:ETE68539.1};
RX PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., Dirks R.P.,
RA Spaink H.P., Duboule D., McGlinn E., Kini R.M., Richardson M.K.;
RT "The king cobra genome reveals dynamic gene evolution and adaptation in the
RT snake venom system.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC -!- FUNCTION: May promote apoptosis. {ECO:0000256|ARBA:ARBA00043845}.
CC -!- SUBCELLULAR LOCATION: Chromosome, centromere
CC {ECO:0000256|ARBA:ARBA00004584}. Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the rad21 family.
CC {ECO:0000256|ARBA:ARBA00009870}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETE68539.1}.
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DR EMBL; AZIM01000992; ETE68539.1; -; Genomic_DNA.
DR AlphaFoldDB; V8P215; -.
DR Proteomes; UP000018936; Unassembled WGS sequence.
DR GO; GO:0008278; C:cohesin complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
DR GO; GO:0007062; P:sister chromatid cohesion; IEA:InterPro.
DR CDD; cd21792; Rad21_Rec8_M_NXP1-like; 1.
DR Gene3D; 1.10.10.580; Structural maintenance of chromosome 1. Chain E; 1.
DR InterPro; IPR049589; NXP1_M-like.
DR InterPro; IPR039781; Rad21/Rec8-like.
DR InterPro; IPR006909; Rad21/Rec8_C_eu.
DR InterPro; IPR006910; Rad21_Rec8_N.
DR InterPro; IPR023093; ScpA-like_C.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR12585:SF20; DOUBLE-STRAND-BREAK REPAIR PROTEIN RAD21 HOMOLOG; 1.
DR PANTHER; PTHR12585; SCC1 / RAD21 FAMILY MEMBER; 1.
DR Pfam; PF04824; Rad21_Rec8; 1.
DR Pfam; PF04825; Rad21_Rec8_N; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 3: Inferred from homology;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Centromere {ECO:0000256|ARBA:ARBA00023328};
KW Chromosome partition {ECO:0000256|ARBA:ARBA00022829};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000018936}.
FT DOMAIN 1..103
FT /note="Rad21/Rec8-like protein N-terminal"
FT /evidence="ECO:0000259|Pfam:PF04825"
FT DOMAIN 466..518
FT /note="Rad21/Rec8-like protein C-terminal eukaryotic"
FT /evidence="ECO:0000259|Pfam:PF04824"
FT REGION 199..230
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 358..444
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 358..387
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 521 AA; 59149 MW; 6005A71AE71BECA4 CRC64;
MFYAHFVLSK RGPLAKIWLA AHWDKKLTKA HVFECNLESS VESIISPKVK MALRTSGHLL
LGVVRIYHRK AKYLLADCNE AFIKIKMAFR PGVVDLPEEN REAAYNAITL PEEFHDFDQP
LPDLDDIDVA QQFSLNQSRV EEITMREEVG NISILQENDF GDFGMDDREM MREVDKLLSN
TEEGIFDDPP ALSEVGVMLP EQPPHDDMDD DDNASMGGPD SPDSADPVEP LPTMTDQTTL
VPNEEEAFAL EPIDITVKET KAKRKRKLIV DSVKELDSKT IRAQLSDYSD IVTTLDLAPP
TKKLMMWKET GGVEKLFSLP AQPLWNNRLL KLFTRCLTPL VPEDLRKRRK GGEADNLDEF
LKDFENPEVP REDQQRNVID EPILEEPSRL QESMMEGSRT NLDESVMPPP PPQTGVKRKA
VQVEPEPVLP EEDGTGGDQD QEERRWNKRT QQMLHGLQRA LAKTGAKSIS LLELCRNTNR
KQAAAKFYSF LVLKKQQAIE LTQEEPYSDI IATPGPRFHI I
//
