ID V8P2F1_OPHHA Unreviewed; 1068 AA.
AC V8P2F1;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Proteinase-activated receptor 2 {ECO:0000313|EMBL:ETE67992.1};
DE Flags: Fragment;
GN Name=F2RL1 {ECO:0000313|EMBL:ETE67992.1};
GN ORFNames=L345_06218 {ECO:0000313|EMBL:ETE67992.1};
OS Ophiophagus hannah (King cobra) (Naja hannah).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE67992.1, ECO:0000313|Proteomes:UP000018936};
RN [1] {ECO:0000313|EMBL:ETE67992.1, ECO:0000313|Proteomes:UP000018936}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Blood {ECO:0000313|EMBL:ETE67992.1};
RX PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., Dirks R.P.,
RA Spaink H.P., Duboule D., McGlinn E., Kini R.M., Richardson M.K.;
RT "The king cobra genome reveals dynamic gene evolution and adaptation in the
RT snake venom system.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000256|RuleBase:RU000688}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETE67992.1}.
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DR EMBL; AZIM01001126; ETE67992.1; -; Genomic_DNA.
DR AlphaFoldDB; V8P2F1; -.
DR Proteomes; UP000018936; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015057; F:thrombin-activated receptor activity; IEA:InterPro.
DR GO; GO:0007596; P:blood coagulation; IEA:InterPro.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 3.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR002281; Pro_rcpt_2.
DR InterPro; IPR003912; Protea_act_rcpt.
DR PANTHER; PTHR24232; G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR24232:SF20; PROTEINASE-ACTIVATED RECEPTOR 1; 1.
DR Pfam; PF00001; 7tm_1; 3.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01428; PROTEASEAR.
DR PRINTS; PR01152; PROTEASEAR2.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 3.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 2.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 3.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR603912-52};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040,
KW ECO:0000256|RuleBase:RU000688};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU000688};
KW Reference proteome {ECO:0000313|Proteomes:UP000018936};
KW Transducer {ECO:0000256|ARBA:ARBA00023224, ECO:0000256|RuleBase:RU000688};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000688};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 83..108
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 120..140
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 160..178
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 199..219
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 245..273
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 293..320
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 332..355
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 448..468
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 488..509
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 530..551
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 580..604
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 624..651
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 750..775
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 784..804
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 824..843
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 864..886
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 916..938
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 959..982
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 994..1018
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 99..352
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
FT DOMAIN 430..681
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
FT DOMAIN 766..1015
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
FT REGION 1045..1068
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 822..900
FT /evidence="ECO:0000256|PIRSR:PIRSR603912-52"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ETE67992.1"
SQ SEQUENCE 1068 AA; 120664 MW; AF43044E89295821 CRC64;
MNKCDFSSVG SSFMNDTRVN PKSFPIKVQE GGGYEPIPLY DNNVENDLEI GSGSSSQSRI
QSLPKYGLVE DVERLLFSGW LTYFVPGVYT LVVSLSLPLN ITAIFLFLQK MKVKKPAIMY
MLNLAVADVL FASVLPFRIV YSFSGNHWPF GPAMCNFVTA TFYCNMYCSI LLMTVISIDR
FLAVVYPMQS LSWRTLRRAS VVCVAIWLVS IAGVVPLLIT EQTTDILPLN VTTCHDVLKE
SDLQAYYRIF FTILFSFFFF VPLIVCTICY VCIIWCLSSS NIAVKSGKRT RALLLSVAVL
SIFIVCFGPT NLLLLVHYVY FSYSNYTGNI YFAYLLCVCI SSVSCCIDPL IYYYASSECQ
RQLSNLLCCR KDSELRSLTS DNPLGSRTSQ RVTGTSTIDN NDVGTYFTNP WLTQFLPTVE
ILMFVLGLPL NALAIHIFVT KTKLWKPAMV YMLNLAFADL LMLSMLPLKI TYLFSGHNWV
FGSIMCQLAA STLMCNMYCS ILLMTGISID RFLALVCPMK SLSWRTARRA SVACFAIWLL
AIVGTSPLMV FDLTVWIPQM NITTCFEAQK ISASVDFFSY YLFTLSTFFF FIPLLISTAC
YICIIRRLFL SKFMVQPGRK RRAIFLSGVV LCTFFLCFGP ANILLLIQLF FPYEHLQSIF
FAHMLSLSLS ALNCCLDPLI YYYASSECQR RVWSVLCPRK LVLVGKMRNK TGVSVGGRSL
VGLQTNSTNK TVYSIDDSAT KILTGKLTTI FLPMVYIIVF IIGLPSNALA LWVFFFRTKK
KHPAVIYMAN LALADLLFVI WFPLKIAYHV NGNNWIYGEV LCKILVGFFY GNMYCSILFM
TCLSVQRYWV IANPILHSRK KSEIAIKVSA AIWILLLLGT MPLYLINQTV HIANLNITTC
HDVLPQSVLA NDMFNYFLSL AIGVFLFPAV LTTGAYILMI KTLNASITDV TIGKKRRRAI
KLIITVLSTY LICFLPSNIL LVVHYAQIKN SNIYALYITA LCLSTLNSCI DPFIYYFISK
DFRDNLKNAL LCRSVRTTKR MQVSLSSNRY PRKSPSYSSS SNTTKSTY
//
