ID V8P2F3_OPHHA Unreviewed; 393 AA.
AC V8P2F3;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=Coagulation factor XIII A chain {ECO:0000313|EMBL:ETE68118.1};
GN Name=F13a1 {ECO:0000313|EMBL:ETE68118.1};
GN ORFNames=L345_06085 {ECO:0000313|EMBL:ETE68118.1};
OS Ophiophagus hannah (King cobra) (Naja hannah).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE68118.1, ECO:0000313|Proteomes:UP000018936};
RN [1] {ECO:0000313|EMBL:ETE68118.1, ECO:0000313|Proteomes:UP000018936}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Blood {ECO:0000313|EMBL:ETE68118.1};
RX PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., Dirks R.P.,
RA Spaink H.P., Duboule D., McGlinn E., Kini R.M., Richardson M.K.;
RT "The king cobra genome reveals dynamic gene evolution and adaptation in the
RT snake venom system.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETE68118.1}.
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DR EMBL; AZIM01001094; ETE68118.1; -; Genomic_DNA.
DR AlphaFoldDB; V8P2F3; -.
DR Proteomes; UP000018936; Unassembled WGS sequence.
DR GO; GO:0003810; F:protein-glutamine gamma-glutamyltransferase activity; IEA:InterPro.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 3.90.260.10; Transglutaminase-like; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR036985; Transglutaminase-like_sf.
DR InterPro; IPR008958; Transglutaminase_C.
DR InterPro; IPR036238; Transglutaminase_C_sf.
DR PANTHER; PTHR11590:SF42; COAGULATION FACTOR XIII A CHAIN; 1.
DR PANTHER; PTHR11590; PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE; 1.
DR Pfam; PF00927; Transglut_C; 2.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF49309; Transglutaminase, two C-terminal domains; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000018936}.
FT DOMAIN 139..240
FT /note="Transglutaminase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00927"
FT DOMAIN 299..388
FT /note="Transglutaminase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00927"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 393 AA; 44216 MW; D0358B2F0540BF29 CRC64;
MSRHDLPVGF GGWQAVDSTP QENSDGMYRC GPASVQAIKH GHVCFQFDAP FVFAEVNSDV
IYSKVMKNGS KVIQHIDKTQ IGTLILTKEM GSNKMKDITE HYKFQEGTEE ERLALETALM
YGVKKSVAED ITSNTEVDMN VVIKDSVLGS DFNVTITFQN KTSRPYTVTA YISGNVVFYT
GVPKTEFKND SFDVTLEPMK AETLEVLIES SEYMSELLEQ ASLHFFVTAR VNELQKILAR
QKTVSLKIPQ LHLKREGYRQ GAQWPQKMGF WDAKEEGVIS PSLLLQAAME LMQSSATWQV
PGEKVVGKEM TIIVEFPNPL KQNLTNVWVR LDGPGVLKPV SKLFREVPTN STLIWEDKYV
PKQSGFRKLI SSLNCDALRH VYGELDINIQ SAE
//
