ID   V8P3D0_OPHHA            Unreviewed;       737 AA.
AC   V8P3D0;
DT   19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT   19-FEB-2014, sequence version 1.
DT   27-MAR-2024, entry version 39.
DE   SubName: Full=Tenascin {ECO:0000313|EMBL:ETE69069.1};
DE   Flags: Fragment;
GN   Name=Tnc {ECO:0000313|EMBL:ETE69069.1};
GN   ORFNames=L345_05133 {ECO:0000313|EMBL:ETE69069.1};
OS   Ophiophagus hannah (King cobra) (Naja hannah).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX   NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE69069.1, ECO:0000313|Proteomes:UP000018936};
RN   [1] {ECO:0000313|EMBL:ETE69069.1, ECO:0000313|Proteomes:UP000018936}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Blood {ECO:0000313|EMBL:ETE69069.1};
RX   PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA   Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA   McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA   Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA   de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA   Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA   Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., Dirks R.P.,
RA   Spaink H.P., Duboule D., McGlinn E., Kini R.M., Richardson M.K.;
RT   "The king cobra genome reveals dynamic gene evolution and adaptation in the
RT   snake venom system.";
RL   Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ETE69069.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AZIM01000856; ETE69069.1; -; Genomic_DNA.
DR   AlphaFoldDB; V8P3D0; -.
DR   Proteomes; UP000018936; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   CDD; cd00063; FN3; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   Gene3D; 2.10.25.10; Laminin; 16.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR013111; EGF_extracell.
DR   InterPro; IPR041161; EGF_Tenascin.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   PANTHER; PTHR46708; TENASCIN; 1.
DR   PANTHER; PTHR46708:SF1; TENASCIN; 1.
DR   Pfam; PF07974; EGF_2; 8.
DR   Pfam; PF18720; EGF_Tenascin; 7.
DR   Pfam; PF00041; fn3; 1.
DR   SMART; SM00181; EGF; 16.
DR   SMART; SM00060; FN3; 1.
DR   SUPFAM; SSF49265; Fibronectin type III; 1.
DR   PROSITE; PS00022; EGF_1; 6.
DR   PROSITE; PS01186; EGF_2; 6.
DR   PROSITE; PS50853; FN3; 1.
PE   4: Predicted;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018936};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           23..737
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004771357"
FT   DOMAIN          652..737
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:ETE69069.1"
FT   NON_TER         737
FT                   /evidence="ECO:0000313|EMBL:ETE69069.1"
SQ   SEQUENCE   737 AA;  80071 MW;  2332D4452DE75674 CRC64;
     MALSAWVLAS VAIFLFHQDA SGGLIKRIIR QKRETGINVT LPEDNQPVVF NHVYNINVPV
     GSLCSVDLDS PSGDSEFKLP SEPGKHYQEH TLNEENQIVF THRINIPRRA CGCAAAPDIK
     ELLSRLEELE ELVSSLQEQC GSGSGCCSSA QTAKECPQNC NERGQCINGQ CICDYGYTGY
     DCGELACPGD CNDQGKCVDG KCVCFDGYAG DDCSFEVCLV PCSEYGNCVN GQCICMEGFT
     GVDCSKPLCL NNCNNRGRCV EEECVCDEGY TGEDCSELIC PNDCYDRGRC INGTCYCETG
     FTGEDCGDLA CPNDCHHNGH CENGVCMCNE GFTGDDCSLL RCPNDCHKQG RCVNGECVCN
     EGFLGPDCGE VRCLNDCHNQ GQCVNGQCVC DEAFMGEDCS ELRCPKDCNN HGQCVGGKCQ
     CDEDYMGEDC GDLRCLHDCH NRGQCIKGQC VCDEGFVGED CSQHRCPNDC HKRGKCVDGQ
     CVCEEAFTGL DCNELRCPND CNDHGRCVDG QCICDEGYTA EDCSELTCPQ DCNRRGRCVN
     GVCECNEGFL GEDCGELACI NNCNNQGHCL NGQCVCDEGF TGVDCGQRKC PDDCNNRGQC
     IDGVCLCDEG YEGPACAGQS CPNNCNDLGR CVAGRCVCEE GFIGADCSDV SPPKKLMVTK
     VTDKTINLEW ANENVVNEYL ISYIPTSIDG LELQFRVPGN KTSATIRELE PGVEYFIRVF
     AILRNKKSIP INARIAT
//