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Database: UniProt
Entry: V8P3L5_OPHHA
LinkDB: V8P3L5_OPHHA
Original site: V8P3L5_OPHHA 
ID   V8P3L5_OPHHA            Unreviewed;      1054 AA.
AC   V8P3L5;
DT   19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT   19-FEB-2014, sequence version 1.
DT   31-JUL-2019, entry version 26.
DE   SubName: Full=A disintegrin and metalloproteinase with thrombospondin motifs 12 {ECO:0000313|EMBL:ETE68566.1};
DE   Flags: Fragment;
GN   Name=ADAMTS12 {ECO:0000313|EMBL:ETE68566.1};
GN   ORFNames=L345_05637 {ECO:0000313|EMBL:ETE68566.1};
OS   Ophiophagus hannah (King cobra) (Naja hannah).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata;
OC   Toxicofera; Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX   NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE68566.1};
RN   [1] {ECO:0000313|EMBL:ETE68566.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Blood {ECO:0000313|EMBL:ETE68566.1};
RX   PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA   Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA   McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA   Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA   de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA   Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA   Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W.,
RA   Dirks R.P., Spaink H.P., Duboule D., McGlinn E., Kini R.M.,
RA   Richardson M.K.;
RT   "The king cobra genome reveals dynamic gene evolution and adaptation
RT   in the snake venom system.";
RL   Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:ETE68566.1}.
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DR   EMBL; AZIM01000990; ETE68566.1; -; Genomic_DNA.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR   Gene3D; 2.20.100.10; -; 5.
DR   Gene3D; 3.40.390.10; -; 1.
DR   InterPro; IPR041645; ADAM_CR_2.
DR   InterPro; IPR010294; ADAM_spacer1.
DR   InterPro; IPR013273; ADAMTS/ADAMTS-like.
DR   InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR   InterPro; IPR001590; Peptidase_M12B.
DR   InterPro; IPR010909; PLAC.
DR   InterPro; IPR000884; TSP1_rpt.
DR   InterPro; IPR036383; TSP1_rpt_sf.
DR   Pfam; PF17771; ADAM_CR_2; 1.
DR   Pfam; PF05986; ADAM_spacer1; 1.
DR   Pfam; PF01421; Reprolysin; 1.
DR   Pfam; PF00090; TSP_1; 5.
DR   PRINTS; PR01857; ADAMTSFAMILY.
DR   SMART; SM00209; TSP1; 5.
DR   SUPFAM; SSF82895; SSF82895; 5.
DR   PROSITE; PS50215; ADAM_MEPRO; 1.
DR   PROSITE; PS50900; PLAC; 1.
DR   PROSITE; PS50092; TSP1; 4.
PE   4: Predicted;
KW   Integrin {ECO:0000313|EMBL:ETE68566.1}.
FT   DOMAIN        1    103       Peptidase M12B. {ECO:0000259|PROSITE:
FT                                PS50215}.
FT   DOMAIN     1005   1045       PLAC. {ECO:0000259|PROSITE:PS50900}.
FT   REGION      687    729       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION      747    800       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS    694    729       Polar. {ECO:0000256|SAM:MobiDB-lite}.
FT   COMPBIAS    749    800       Polar. {ECO:0000256|SAM:MobiDB-lite}.
FT   NON_TER       1      1       {ECO:0000313|EMBL:ETE68566.1}.
SQ   SEQUENCE   1054 AA;  118110 MW;  63FE511213D75CC2 CRC64;
     MNQPCETLGL SHLSGMCQPH RSCNINEDSG LPLAFTIAHE LGHSFGIQHD GKENDCEPVG
     RRPYIMSRQL QYDPTPLTWS RCSKEYITRF LDHGLGFCLD DVPKKKDLKP PFIAPGVIYD
     VHHQCQLQYG PNATFCDQVD NICQTLWCFV KSSCRSKLDA AADGTRCGEN KWCFSGECIT
     VGKSPEAING AWGSWSPWSH CTRTCGAGVQ AAERHCNNPE PQFGGKYCTG ERKHYRMCNV
     KGCQKSTPNF REMQCSEFDT VAYKNEFYQW IPIYNTANPC ELQCQPTNQH FSEKMLDAVI
     DGTPCFEGNS YRDVCINGMC KTVGCDYEIN SNATEDQCGV CLGDGSYCQT VKITFNQSEG
     LGYVDIGLIP KGARHIKVVE ESEAGNFLAL RSEDPQKHYL NGGFIIQWNG DYEVAGTIFQ
     WWAGEWQKCS TTCGPTGEKK RTVLCIQTLG LDEQALPAEE CQHLLKPKTR LSCNRDVLCP
     SDWTVSNWTE CTVTCGGGVR TRYVTCTKNN GEPCDVSKKP HSKALCGLQQ CLSTQRLLMT
     HFKFHNGKII RRIGAIPRRG PSKKLATPEP LPRIHSTIMP RLRNITLIPT SISLVNSSSN
     EDLEVKKLQN NSIDSSIPSN YSYVTSANRA LQNITHGPLI TAWTISSEGS SININKDSFT
     IDPMYNPKTN YLMEANDTNS TEREIKDYIQ TERPTERSLT FTTSKSSRTS STDNQPDNPD
     QFSVTPTRGI EVSSTAIALK GLRVQINPPV TSDPITEQPT LENTLEEKSA NTTPSKSSFS
     ETSPWATESP FVRDPTMPTN SENAFKTRLL NESDSENSRN LHTNAYWLVG NWTEKWQHYF
     SPIFQCSTTC GIGAFWRPVE CNTKNESDCQ HIKKPDPARR CYLRPCAQWR IGNWSKCSSS
     CGGGFKTRDA HCIDVREKRL LRPFHCQVIQ SQPVLNMSCN MDPCFVWHTE SWNECSASCG
     GGTQKRPVQC VRVDDHATKE ENWCQQETKP PDSQKCNLQK CVKNTGSTCS KDRLSVNFCE
     KVRDIGKCSA PSVRIQCCQT CKRSLAVNEM EPGN
//
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