ID V8P5G7_OPHHA Unreviewed; 887 AA.
AC V8P5G7;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Lymphocyte antigen 75 {ECO:0000313|EMBL:ETE69555.1};
DE Flags: Fragment;
GN Name=LY75 {ECO:0000313|EMBL:ETE69555.1};
GN ORFNames=L345_04643 {ECO:0000313|EMBL:ETE69555.1};
OS Ophiophagus hannah (King cobra) (Naja hannah).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE69555.1, ECO:0000313|Proteomes:UP000018936};
RN [1] {ECO:0000313|EMBL:ETE69555.1, ECO:0000313|Proteomes:UP000018936}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Blood {ECO:0000313|EMBL:ETE69555.1};
RX PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., Dirks R.P.,
RA Spaink H.P., Duboule D., McGlinn E., Kini R.M., Richardson M.K.;
RT "The king cobra genome reveals dynamic gene evolution and adaptation in the
RT snake venom system.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the true venom lectin family.
CC {ECO:0000256|ARBA:ARBA00006250}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETE69555.1}.
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DR EMBL; AZIM01000741; ETE69555.1; -; Genomic_DNA.
DR AlphaFoldDB; V8P5G7; -.
DR Proteomes; UP000018936; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR CDD; cd00037; CLECT; 4.
DR CDD; cd00161; RICIN; 1.
DR Gene3D; 2.80.10.50; -; 1.
DR Gene3D; 2.10.10.10; Fibronectin, type II, collagen-binding; 1.
DR Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 4.
DR InterPro; IPR001304; C-type_lectin-like.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR018378; C-type_lectin_CS.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR000562; FN_type2_dom.
DR InterPro; IPR036943; FN_type2_sf.
DR InterPro; IPR013806; Kringle-like.
DR InterPro; IPR035992; Ricin_B-like_lectins.
DR InterPro; IPR000772; Ricin_B_lectin.
DR PANTHER; PTHR22803:SF65; LYMPHOCYTE ANTIGEN 75; 1.
DR PANTHER; PTHR22803; MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED; 1.
DR Pfam; PF00040; fn2; 1.
DR Pfam; PF00059; Lectin_C; 4.
DR SMART; SM00034; CLECT; 4.
DR SMART; SM00059; FN2; 1.
DR SMART; SM00458; RICIN; 1.
DR SUPFAM; SSF56436; C-type lectin-like; 4.
DR SUPFAM; SSF57440; Kringle-like; 1.
DR SUPFAM; SSF50370; Ricin B-like lectins; 1.
DR PROSITE; PS00615; C_TYPE_LECTIN_1; 1.
DR PROSITE; PS50041; C_TYPE_LECTIN_2; 4.
DR PROSITE; PS50231; RICIN_B_LECTIN; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000018936};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 237..353
FT /note="C-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50041"
FT DOMAIN 381..490
FT /note="C-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50041"
FT DOMAIN 509..624
FT /note="C-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50041"
FT DOMAIN 655..798
FT /note="C-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50041"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ETE69555.1"
SQ SEQUENCE 887 AA; 102416 MW; 9A001E9D21CA43FC CRC64;
MGHIFKIKQN LQSAFQLNTL NIAQLFSFQI APGKCPKQAA EQKKTQKYIL FFHADNNLFT
IRHENSNKCI QVKSQHLILG SCEETDESLW TWVSQHRLFN LGSQKCLGLE TVKSTNTLKM
FACDSELNLW WRCVGDSILS TSQNKLALKN GILTISLNSS DAWRRSNSRD TICKFPYSES
YTRDGNAYGK PCEFPFLHNN TWYHDCIYNE KYTGDLRYEY LSSTEDGCQN TWEQFKDSGN
CYQLNTQAAL SWKAAYLSCK KQGSDLVSIT SASELNYIRA KDGVAEIFWI GLNQLDVSGG
WQWSDHNPLN FVNWNSEMQD VSPLEGNDCA AMNADTGDWK SYPCDTPLPY VCKKQVNDSQ
PDFPDIQNNV ETQCESGWYA NNGFCYMLKN NIASWNDSYQ LCSELNSSLI SIHSLADVEL
VITKLHNGLM NKEIPAFFKW SDDSKVIFTY WDQNEPRVSF KSLPNCVSYS GKFGRWNILP
CNNKLKFVCM KKGKVLEEPK SDKACSPSKE WKKHGDYCYR IDKKEVFFGS VCNLTIANRF
EQEFINNLIR MHNKLEEKYF WTGLQDISSS GEYRWGSVDG NNELLTYTNW GSFQPEFRGG
CVAMPNGRYI GKWEVKDCQT FKAYSICKKY VGPKRETEIM PKTTDPCPQG WSRGSGLSCY
KFFHKERVLR TRTWEEAERF CEALGGHLPS FSDSEEIREL HTILRETISD DRWVWIGLNK
RKPDLLGSWQ WSDNKPVSSV VMPLEFREDD YDLRDCAAVK TVGRKRQPLY HIYLFEDREE
DFYLKPFHCD VQLEWVCQIP KDEEEIHGPT VNVDGSEFWF VANKHLSYQE ASLYCSENGS
SSLGCSAKLP FICEKYNASL LETSEPGYKP PEESCPENWI FFLNKIL
//
