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Database: UniProt
Entry: V8P5L3_OPHHA
LinkDB: V8P5L3_OPHHA
Original site: V8P5L3_OPHHA 
ID   V8P5L3_OPHHA            Unreviewed;      1409 AA.
AC   V8P5L3;
DT   19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT   19-FEB-2014, sequence version 1.
DT   22-FEB-2023, entry version 40.
DE   SubName: Full=Myosin-X {ECO:0000313|EMBL:ETE69172.1};
GN   Name=MYO10 {ECO:0000313|EMBL:ETE69172.1};
GN   ORFNames=L345_05024 {ECO:0000313|EMBL:ETE69172.1};
OS   Ophiophagus hannah (King cobra) (Naja hannah).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX   NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE69172.1, ECO:0000313|Proteomes:UP000018936};
RN   [1] {ECO:0000313|EMBL:ETE69172.1, ECO:0000313|Proteomes:UP000018936}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Blood {ECO:0000313|EMBL:ETE69172.1};
RX   PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA   Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA   McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA   Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA   de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA   Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA   Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., Dirks R.P.,
RA   Spaink H.P., Duboule D., McGlinn E., Kini R.M., Richardson M.K.;
RT   "The king cobra genome reveals dynamic gene evolution and adaptation in the
RT   snake venom system.";
RL   Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC   -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC       superfamily. Myosin family. {ECO:0000256|PROSITE-ProRule:PRU00782}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00782}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ETE69172.1}.
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DR   EMBL; AZIM01000833; ETE69172.1; -; Genomic_DNA.
DR   Proteomes; UP000018936; Unassembled WGS sequence.
DR   GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003774; F:cytoskeletal motor activity; IEA:InterPro.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd14473; FERM_B-lobe; 1.
DR   CDD; cd13202; FERM_C_MyoX; 1.
DR   CDD; cd17206; FERM_F1_Myosin-X; 1.
DR   CDD; cd13296; PH2_MyoX; 1.
DR   CDD; cd13297; PH3_MyoX-like; 1.
DR   Gene3D; 1.20.5.170; -; 1.
DR   Gene3D; 1.20.5.190; -; 1.
DR   Gene3D; 1.20.80.10; -; 1.
DR   Gene3D; 6.20.240.20; -; 1.
DR   Gene3D; 1.25.40.530; MyTH4 domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 4.
DR   InterPro; IPR019749; Band_41_domain.
DR   InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR   InterPro; IPR035963; FERM_2.
DR   InterPro; IPR019748; FERM_central.
DR   InterPro; IPR000299; FERM_domain.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR031971; MYO10_CC.
DR   InterPro; IPR001609; Myosin_head_motor_dom.
DR   InterPro; IPR041797; MyoX_FERM_C.
DR   InterPro; IPR000857; MyTH4_dom.
DR   InterPro; IPR038185; MyTH4_dom_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR000159; RA_dom.
DR   PANTHER; PTHR46049; AGAP003327-PA; 1.
DR   PANTHER; PTHR46049:SF2; UNCONVENTIONAL MYOSIN-X; 1.
DR   Pfam; PF00373; FERM_M; 1.
DR   Pfam; PF00612; IQ; 2.
DR   Pfam; PF16735; MYO10_CC; 1.
DR   Pfam; PF00063; Myosin_head; 1.
DR   Pfam; PF00784; MyTH4; 1.
DR   Pfam; PF00169; PH; 2.
DR   Pfam; PF00788; RA; 1.
DR   SMART; SM00295; B41; 1.
DR   SMART; SM00015; IQ; 3.
DR   SMART; SM00139; MyTH4; 1.
DR   SMART; SM00233; PH; 2.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF50729; PH domain-like; 4.
DR   SUPFAM; SSF47031; Second domain of FERM; 1.
DR   PROSITE; PS50057; FERM_3; 1.
DR   PROSITE; PS50096; IQ; 2.
DR   PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR   PROSITE; PS51016; MYTH4; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 2.
DR   PROSITE; PS50200; RA; 1.
PE   3: Inferred from homology;
KW   Actin-binding {ECO:0000256|PROSITE-ProRule:PRU00782};
KW   Motor protein {ECO:0000256|PROSITE-ProRule:PRU00782};
KW   Myosin {ECO:0000256|PROSITE-ProRule:PRU00782};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018936}.
FT   DOMAIN          1..96
FT                   /note="Myosin motor"
FT                   /evidence="ECO:0000259|PROSITE:PS51456"
FT   DOMAIN          559..657
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          739..844
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          882..1042
FT                   /note="MyTH4"
FT                   /evidence="ECO:0000259|PROSITE:PS51016"
FT   DOMAIN          1047..1392
FT                   /note="FERM"
FT                   /evidence="ECO:0000259|PROSITE:PS50057"
FT   DOMAIN          1051..1093
FT                   /note="Ras-associating"
FT                   /evidence="ECO:0000259|PROSITE:PS50200"
FT   REGION          175..194
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          315..388
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          405..426
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        343..372
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1409 AA;  162716 MW;  D43931F312C98D3B CRC64;
     MPDQFDQNVV LNQLCYSGML ETVRIRRAGF PVRRPFQDFH KRYKILMRNL TLPEDLKGKC
     TALLYLYDST KTEWQLGKSK VFLRESLEHM LEKQREIEVG KAAMIIRAHV LGYMARKHYK
     KVLYYVVIIQ KNYRAFYLRR RYLLLKKAAI TFQKQVRGLI ARRIYKQLLE EKKQQEEGKR
     QREEEKRKQQ KMEAERLAQQ AKEALVVIPK PPKELKQELE RQKENKQVEE ILRLEKEIED
     LQRMKEQQEL TLTEASLQRL QQLRDDELKR LEDEACRAAQ EFLESLNFDE IDECVRNIER
     TLSVSSSFCA ELSGTTGTEK PNFNFSQPYP EEEVDEGFEA DDDAFKDSPN PSEHGHSDQR
     TSGIRTSDDS SEEDPYMNDT VVPASPATGN NTIIPSILDS LSLHNSSSGE STYCMPENVS
     RQPPNASELI SPEADYDYDQ DDYEDGAITS GSSVTFSNSH SSQWSPDYRC SIGTYNSSGA
     YRFSSEGAQS SFEDSEEDFD SRFDTDDELS YRRDSVYSCV SLPYFHSFLY MKGGLINTWK
     RRWCVLKDET FLWFRSKQEA LKQGWLHKKG GGSSTLSRRN WKKRWFVLRQ SRLMYFENDG
     EEKLKGTLEI RSAKDIIDNT CKENGIDIVM TDRTYHLIAE SPEDASQWFS VLSQVLTSTE
     QEIREMHDEQ ANPQNAMGTL DVGLIDSVCA SDSPDRPNSF VIITANRVLH CNADTPEEMH
     HWITLLQRSK GDTRVEGQEF IVRGWLHKEV KNSPKMSSLK LKKRWFVLTH NSLDYYKSSE
     KNALKLGTLV LNSLCSAVPP DEKIFKETGY WNVTVYGRKH CYRLYTKLLN EATRWSSAIQ
     NVIDTKAAID TPTQQLIQDI KENCLNPEVV EQIYKRNPIL RYTQHPLHSP LLPLPYGDIN
     LNILRDKGYT TLQDEAIKIF NSLQQLESVP DPIPIIQGIL QTGHDLRPLR DELYCQLIKQ
     TCKVPNTGSL GNLYSWQILT CMSCMFLPSR SILKYLKFHL KRIHDQFPGT EMAKYALFIY
     ESLKKTKGRE FVPSRDEIET LINRQEMTST VYCHGGGSCK ITINSHTTAG EVVEKLIRGL
     GMEDSRNMFA LFEYNGITDK AIESRTVVAD VLAKFEKIGA TSEGDHAAWK FYFKLYCFLD
     IEHVPKDSVE FAFMFEQAHE AMIQGHFPAP EETLQVLAAL RLQYLQGDYS SSNVTVPEME
     DVYPLQRLKS RIVQSTKIFV PTERFERKRN NFLEGTLRRS FRSSSVTKQK MEEDQMLNMW
     VREEISAART SMLDKWKKMQ GMTQEQAMAK YMNLIKEWPG YGSTLFDVEC KEGGFPQELW
     LGVSAEAVSV YKRGEGRPLE VFQYEHILSF GAPLANVYKI VVDERELLFG TTEVIDIAKL
     MKAYISMIVK KRYSTSRSVS SHGSQSSCR
//
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