ID V8P5S7_OPHHA Unreviewed; 413 AA.
AC V8P5S7;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Deleted in malignant brain tumors 1 protein {ECO:0000313|EMBL:ETE69237.1};
DE Flags: Fragment;
GN Name=Dmbt1 {ECO:0000313|EMBL:ETE69237.1};
GN ORFNames=L345_04956 {ECO:0000313|EMBL:ETE69237.1};
OS Ophiophagus hannah (King cobra) (Naja hannah).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE69237.1, ECO:0000313|Proteomes:UP000018936};
RN [1] {ECO:0000313|EMBL:ETE69237.1, ECO:0000313|Proteomes:UP000018936}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Blood {ECO:0000313|EMBL:ETE69237.1};
RX PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., Dirks R.P.,
RA Spaink H.P., Duboule D., McGlinn E., Kini R.M., Richardson M.K.;
RT "The king cobra genome reveals dynamic gene evolution and adaptation in the
RT snake venom system.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00059}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETE69237.1}.
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DR EMBL; AZIM01000810; ETE69237.1; -; Genomic_DNA.
DR AlphaFoldDB; V8P5S7; -.
DR Proteomes; UP000018936; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR CDD; cd00041; CUB; 1.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 1.
DR Gene3D; 2.60.40.4100; Zona pellucida, ZP-C domain; 1.
DR Gene3D; 2.60.40.3210; Zona pellucida, ZP-N domain; 1.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR InterPro; IPR042235; ZP-C.
DR InterPro; IPR001507; ZP_dom.
DR InterPro; IPR017977; ZP_dom_CS.
DR PANTHER; PTHR14002; ENDOGLIN/TGF-BETA RECEPTOR TYPE III; 1.
DR PANTHER; PTHR14002:SF53; ZP DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR Pfam; PF00431; CUB; 1.
DR Pfam; PF00100; Zona_pellucida; 1.
DR SMART; SM00042; CUB; 1.
DR SMART; SM00241; ZP; 1.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 1.
DR PROSITE; PS01180; CUB; 1.
DR PROSITE; PS00682; ZP_1; 1.
DR PROSITE; PS51034; ZP_2; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000018936};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 24..132
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 137..383
FT /note="ZP"
FT /evidence="ECO:0000259|PROSITE:PS51034"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ETE69237.1"
SQ SEQUENCE 413 AA; 47017 MW; DEFA54CA416682BE CRC64;
KLVFLTGSST PAPPVTETIP TNQCGGQLTN AYGSFSGPFY PGNHSNMTCV WKIQVRRFER
INLKFSSINL DCDKEYVEIF DGLRYGSYPL GRTCSSAYLN YTYSSTSNIM TIVLYRDSGD
SGNGFFAHYY SIPQGLSCSD GFMRARISRS YLNSIGYNAS QVYLNSLDRS CKSQIASDYV
YFIIPFYGCN TEIRVKNDTI TYYNVIKTLN SDYIITRKKN FQFHVLCEMK QNTIVQTMFI
AQNAIDLTER RIGHYNVSLA FYSSLSFTHK IVRSPFYVSL NQNLYLQATL HTADPNIVLF
LDTCIASPDS NDFRTLTYDL IRSGCPRDST YRNLSSPANN IVRFQFNSFK FLNKHNSVYI
QCKLVVCRAG DRSSRCHQGC SLRKKRGVDE SQEKVNVVVG PLKLLKDENE VQK
//
