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Database: UniProt
Entry: V8P7T7_OPHHA
LinkDB: V8P7T7_OPHHA
Original site: V8P7T7_OPHHA 
ID   V8P7T7_OPHHA            Unreviewed;       941 AA.
AC   V8P7T7;
DT   19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT   19-FEB-2014, sequence version 1.
DT   25-OCT-2017, entry version 17.
DE   SubName: Full=Short transient receptor potential channel 3 {ECO:0000313|EMBL:ETE70410.1};
DE   Flags: Fragment;
GN   Name=TRPC3 {ECO:0000313|EMBL:ETE70410.1};
GN   ORFNames=L345_03779 {ECO:0000313|EMBL:ETE70410.1};
OS   Ophiophagus hannah (King cobra) (Naja hannah).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata;
OC   Toxicofera; Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX   NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE70410.1, ECO:0000313|Proteomes:UP000018936};
RN   [1] {ECO:0000313|EMBL:ETE70410.1, ECO:0000313|Proteomes:UP000018936}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Blood {ECO:0000313|EMBL:ETE70410.1};
RX   PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA   Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA   McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA   Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA   de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA   Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA   Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W.,
RA   Dirks R.P., Spaink H.P., Duboule D., McGlinn E., Kini R.M.,
RA   Richardson M.K.;
RT   "The king cobra genome reveals dynamic gene evolution and adaptation
RT   in the snake venom system.";
RL   Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:ETE70410.1}.
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DR   EMBL; AZIM01000556; ETE70410.1; -; Genomic_DNA.
DR   Proteomes; UP000018936; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005262; F:calcium channel activity; IEA:InterPro.
DR   CDD; cd00204; ANK; 1.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR020683; Ankyrin_rpt-contain_dom.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR004729; TRP_channel.
DR   InterPro; IPR013555; TRP_dom.
DR   InterPro; IPR005459; TRPC3_channel.
DR   InterPro; IPR002153; TRPC_channel.
DR   PANTHER; PTHR10117; PTHR10117; 1.
DR   PANTHER; PTHR10117:SF8; PTHR10117:SF8; 1.
DR   Pfam; PF12796; Ank_2; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF08344; TRP_2; 1.
DR   PRINTS; PR01097; TRNSRECEPTRP.
DR   PRINTS; PR01644; TRPCHANNEL3.
DR   SMART; SM00248; ANK; 3.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   TIGRFAMs; TIGR00870; trp; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
PE   4: Predicted;
KW   ANK repeat {ECO:0000256|SAAS:SAAS00933366};
KW   Complete proteome {ECO:0000313|Proteomes:UP000018936};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|EMBL:ETE70410.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018936};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    424    448       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    460    480       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    511    528       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    549    570       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    658    678       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    726    748       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      135    185       ANK_REP_REGION. {ECO:0000259|PROSITE:
FT                                PS50297}.
FT   NON_TER       1      1       {ECO:0000313|EMBL:ETE70410.1}.
SQ   SEQUENCE   941 AA;  107660 MW;  A3915AEC5427C822 CRC64;
     MSGTGKRIKE RGSVTFTQQQ QQDEEEEEEE EEGTSEEETP LPPPSQQPRA RRGWRGVNGG
     LEPPQHQAVK TQRETYGCHP PLPVVGNVFI DGSPSLRQTT MMREKGRRQA IRGPAFMFND
     RGTSLTAEEE RFLDAAEYGN IPVVRKMLEE SKTLNVNCVD YMGQNALQLA VGNEHLEVTE
     LLLKKENLAR IGDALLLAIS KGYIRIVEAI LNHPGFAASK RLTLSPCEQE LQDDDFYSYD
     EDGTRFSPDI TPIILAAHCQ KYEVVHMLLM KGARIERPHD YFCKCNDCTE KQKIDSFSHS
     RSRINAYKGL ASPAYLSLSS EDPVLTALEL SNELAKLANI EKEFKNDYRK LSMQCKDFVV
     GVLDLCRDSE EVEAILNGDL EAEPVEIQRH RASLSRVKLA IKYEVKKLLT IWYENLSGLR
     EQTIAIKCLV VLVVALGLPF LATGYWIAPC SRLGKILRSP FMKFVAHAAS FIIFLGLLVF
     NASDRFEGIS VLPNETVIDY PKQIFRVKTT QFTWTEMLIM IWVLGMMWSE CKELWLEGPR
     EYILQLWNVL DFGMLSIFIA AFTARLLAFL QATKAQNYVD KYIQETDLSV VTLPPNIEYF
     TYARDKWLPS DPQIISEGLY AIAVVLSFSR IAYILPANES FGPLQISLGR TVKDIFKFMV
     LFIMVFLAFM IGMFILYSYY LGAKVNAAFT TVEESFKTLF WSIFGLSEVT SVVLKYDHKF
     IENIGYVLYG IYNVTMVVVL LNMLIAMINS SYQEIEDDSD VEWKFARSKL WLSYFDDGKT
     LPPPFSLVPS PKSFFYFFMK IIKLLRCRRK RLQKDMEMGI GNSKSRLNLF SQSNSRVFES
     HSFNSILNQP SRYQQIMKRL IKRYVLKAQV DKENDEVNEG ELKEIKQDIS SLRYELLEDK
     SQATEELAIL IHKLSEKLNP NISRSQSYAM GTECLTVKNT K
//
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