ID V8P843_OPHHA Unreviewed; 1603 AA.
AC V8P843;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Tubulin polyglutamylase TTLL4 {ECO:0000313|EMBL:ETE70734.1};
DE Flags: Fragment;
GN Name=Ttll4 {ECO:0000313|EMBL:ETE70734.1};
GN ORFNames=L345_03465 {ECO:0000313|EMBL:ETE70734.1};
OS Ophiophagus hannah (King cobra) (Naja hannah).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE70734.1, ECO:0000313|Proteomes:UP000018936};
RN [1] {ECO:0000313|EMBL:ETE70734.1, ECO:0000313|Proteomes:UP000018936}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Blood {ECO:0000313|EMBL:ETE70734.1};
RX PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., Dirks R.P.,
RA Spaink H.P., Duboule D., McGlinn E., Kini R.M., Richardson M.K.;
RT "The king cobra genome reveals dynamic gene evolution and adaptation in the
RT snake venom system.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETE70734.1}.
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DR EMBL; AZIM01000489; ETE70734.1; -; Genomic_DNA.
DR Proteomes; UP000018936; Unassembled WGS sequence.
DR GO; GO:0036211; P:protein modification process; IEA:InterPro.
DR CDD; cd04618; CBS_euAMPK_gamma-like_repeat1; 1.
DR CDD; cd04641; CBS_euAMPK_gamma-like_repeat2; 1.
DR Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR Gene3D; 3.10.580.10; CBS-domain; 2.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR004344; TTL/TTLL_fam.
DR PANTHER; PTHR12241:SF162; TUBULIN MONOGLUTAMYLASE TTLL4; 1.
DR PANTHER; PTHR12241; TUBULIN POLYGLUTAMYLASE; 1.
DR Pfam; PF00571; CBS; 3.
DR Pfam; PF03133; TTL; 1.
DR SMART; SM00116; CBS; 4.
DR SUPFAM; SSF54631; CBS-domain pair; 2.
DR SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR PROSITE; PS51371; CBS; 4.
DR PROSITE; PS51221; TTL; 1.
PE 4: Predicted;
KW CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW Reference proteome {ECO:0000313|Proteomes:UP000018936}.
FT DOMAIN 1318..1378
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 1400..1461
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 1469..1529
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 1541..1600
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT REGION 191..215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 234..288
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 510..549
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1069..1096
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1218..1240
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1256..1276
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 234..256
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 510..540
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ETE70734.1"
SQ SEQUENCE 1603 AA; 179471 MW; A74CF015C21C7F3E CRC64;
MAAIAGHSKN AALTKSCSKA VIIEGVGWLY MASAGPEAYS LSLKKRNQFQ VGISPGLSVP
PLTAKLHKSK SWYLAKQQVK PVWQLEQNHV TTLQDECSAH SGISSQRPRL LYPESLCSEA
VLRSPPTVQS HSLPNFLGST LLYRRSYFRH KPYRRLESIC FQTSTLEKKP LCVPPPVYHS
VLNNTMSSST VDPFLMPSTA GERSNPVSKG FLLNSGKQTS SAYRPVLNNN SFLRPASAKV
PLQQQQQQQQ QQPLPPENKK LKGLSRPPGF SWTHSGGNGD GYPINLEKKL GKNSNSTFEQ
SCAKSPRSPV HNGMVLKSER SLWPIEDGET RSQNLKEQDA RLTEAMRKLT ASGIRKVSTY
SEFGHRIDSS CLMNASFHAN LFNRWKPHIV AQITPKEVPV PSSLNLESGS RHQSLISTES
ADVCTKRIDT RSLTSNSEMP NHSILNQLVN TPVNITEQVV TAEVSPRMIV SEVETKISTL
QLSMEAKWGQ PTMKESEAVV NLPLLDQAEV EDVEEELPDG LEDACSQDEE GEEEDGEGES
DGSSSSSLSA NGSVAVISRT CVEGLVPPLE GQERITKPAL AHSLFPNVPS TIYFGTRDER
VEKLPWEQRK MLRWKMSTVT PNIVKQTIAR SHFKISRRNN DWLGCWGHHM KSPGFRIVKE
HQKLNHFPGS FQIGRKDRLW RNVSKMQVRF GRKEFNFLPQ SFILPQDIKL LRKAWEDCGG
RQKWIVKPPA SARGIGIQVI HKWSQLPKRR PLLVQRYSSS MKSLNNKYMH LTNYSINKKN
VEYKSNADET ACQGHKWALK ALWNYLTQKG VDSEAIWEKI KDIVVKTIIA SEPYIINLVK
MYVRRPYCCH ELFGFDVMLD ENLKPWILEV NISPSLHSNS PLDVSIKGQM VRDALNLAGF
QLPNAEDVAS PSGSASSSTT SLNTVMKEKN KPPVELLTAE KAKKAYYLTQ KLPEQEFCST
ILDVLTPDDV RVLIETEDEY ARRGQFERVF PSRFSAHYLR FFEQPRYFNI LTTQWELKYF
LNKSKGVDLL RNWCHKGFHN GIVTDSTVLW TLPRPHLYLK NDLINALSKV DPGRNSKGPR
DGEEPVRNPE PSSCTQTLPQ IKHAVGTLKK STISNALSNS NGIKSFNVSI YPLGPASSLD
TEESALKANV VVQEAKDLTA SDKEVNLIMT NVVADGRTER WDPEPTVFDA ETATHIGKVT
AADAIAVELD FKSTHSETKD LDRAHSDSGA GNDMIPQGRM KDWSTTASTQ ISEDTGQFNK
GTVLGPSTGX GKQEEDDDDV ISLDCEILGF GPDIEFLGPD AEIYMQFMRS HRCYDAIPTS
SKLVVFETTL QIKKAFLALV ANGVRAAPLW DSKQQCFVGM LTITDFINIL HRYYRSPLVQ
IYEIEGHKIE TWREVYLQGS FKPLVHISPN HSLFDAVYSL IKNKIHRLPV IDPISGNVLH
ILTHKRILKF LHIFVSAGKK TIHELGIGTF RDIAMVIDSA PVYTALEIFV DRRVSALPVV
NEKGTVVGLY SRFDVIHLAA QKSYNNLDIS VGEALKQRSV CLEGVLTCHP YETLEDIIDR
IAKEQVHRLV LVDKKNTPRG IVSLSDILQA LVLTPAGIDA LNS
//
