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Database: UniProt
Entry: V8P870_OPHHA
LinkDB: V8P870_OPHHA
Original site: V8P870_OPHHA 
ID   V8P870_OPHHA            Unreviewed;      1553 AA.
AC   V8P870;
DT   19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT   19-FEB-2014, sequence version 1.
DT   05-JUN-2019, entry version 26.
DE   SubName: Full=A disintegrin and metalloproteinase with thrombospondin motifs 9 {ECO:0000313|EMBL:ETE70213.1};
DE   Flags: Fragment;
GN   Name=ADAMTS9 {ECO:0000313|EMBL:ETE70213.1};
GN   ORFNames=L345_03981 {ECO:0000313|EMBL:ETE70213.1};
OS   Ophiophagus hannah (King cobra) (Naja hannah).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata;
OC   Toxicofera; Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX   NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE70213.1};
RN   [1] {ECO:0000313|EMBL:ETE70213.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Blood {ECO:0000313|EMBL:ETE70213.1};
RX   PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA   Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA   McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA   Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA   de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA   Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA   Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W.,
RA   Dirks R.P., Spaink H.P., Duboule D., McGlinn E., Kini R.M.,
RA   Richardson M.K.;
RT   "The king cobra genome reveals dynamic gene evolution and adaptation
RT   in the snake venom system.";
RL   Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:ETE70213.1}.
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DR   EMBL; AZIM01000591; ETE70213.1; -; Genomic_DNA.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR   Gene3D; 2.20.100.10; -; 9.
DR   Gene3D; 3.40.390.10; -; 1.
DR   InterPro; IPR010294; ADAM_spacer1.
DR   InterPro; IPR013273; ADAMTS/ADAMTS-like.
DR   InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR   InterPro; IPR012314; Pept_M12B_GON-ADAMTSs.
DR   InterPro; IPR001590; Peptidase_M12B.
DR   InterPro; IPR002870; Peptidase_M12B_N.
DR   InterPro; IPR000884; TSP1_rpt.
DR   InterPro; IPR036383; TSP1_rpt_sf.
DR   Pfam; PF05986; ADAM_spacer1; 1.
DR   Pfam; PF08685; GON; 2.
DR   Pfam; PF01562; Pep_M12B_propep; 1.
DR   Pfam; PF01421; Reprolysin; 1.
DR   Pfam; PF00090; TSP_1; 9.
DR   PRINTS; PR01857; ADAMTSFAMILY.
DR   SMART; SM00209; TSP1; 10.
DR   SUPFAM; SSF82895; SSF82895; 9.
DR   PROSITE; PS50215; ADAM_MEPRO; 1.
DR   PROSITE; PS51046; GON; 1.
DR   PROSITE; PS50092; TSP1; 8.
PE   4: Predicted;
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00117091};
KW   Integrin {ECO:0000313|EMBL:ETE70213.1};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     24       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        25   1553       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5004771269.
FT   DOMAIN      355    453       Peptidase M12B. {ECO:0000259|PROSITE:
FT                                PS50215}.
FT   DOMAIN     1388   1553       GON. {ECO:0000259|PROSITE:PS51046}.
FT   REGION     1057   1083       Disordered. {ECO:0000256|MobiDB-lite:
FT                                V8P870}.
FT   NON_TER       1      1       {ECO:0000313|EMBL:ETE70213.1}.
SQ   SEQUENCE   1553 AA;  172893 MW;  2E1D04463B82C786 CRC64;
     MQLVLWAVGL STLLLQDFLN RAGAAAAAAA AATAARKQGR HLRQAKLLET LREYEIVIPT
     RVNELGEPLP AKVHFERRKR SLPSEAEPWI LDAPSPPIAP SFFSTTQVHY RLQAFGQHFV
     FNLTAHSGFI APLFTVSFLG QPEVNQTNFY TEEESDIKHC FYKGHVNTEP QHTAVISLCS
     GMLCDVSLIP SQLGTFRSHD GEYFVEPLIS PDQQEYEEEN KKPHIVYRHS VSPTLSPRNK
     QTCDISGTFC LYFLRPLIQE IQNSWKETRD LAQFISSPWK IEATDPRPQQ GKATDKMISQ
     ALHASALCSG EGFLIEVKCS PEAQSSSNPA LLISFALKVC FAFRQDICRA HDKCDTLGLA
     ELGTVCDPYR SCSISEDSGL STAFTIAHEL GHVFNMPHDD NNKCKEEGGK SQQHVMAPTL
     NYNTNPWMWS KCSRKYITEF LDSEDNCDAF HSSTGYGECL LDEPSSRTYT LPQQLPGHMY
     DVNKQCELIF GPGAKHCKYG HCVPKEREIP MTDGAWGAWS PFGACSRTCG GGIKNAIREC
     NRPEVLSCLG NITHTRRHQL IEQAQPVLMK DRCKLFCRVA GNTAYYQLRD RVIDGTPCGP
     DTNDICVQGL CRQAGCDHVL NSKARRDKCG VCGGDNSSCK TIAGTFNTVH YGYNTVIRIP
     AGATNIDVRQ HSYSGKPEDD NYLALSSNEG FILNGDYVVS MFKKEIKIGN AVIEYSGSDT
     PVERINSTYR IDQEIVLQVL SVGNLYNPDV RYTFNIPIED KPQQFYWNVY GPWQPCSKLC
     QGTWHIVRKS ECSVQCGMGY KTLEISCAKY SKLEGKIEKY DDRYCSGISK PNSREKCSGD
     CNTGGWRYSA WTECLVTCGK GHKHRQIWCQ FGEDRINDRL CDLDGKPDSM QDCQQQECAA
     WQVGPWGQCT VTCGQGYQMR AVKCVVGAYI SVVDDNECNA ATKPTDTQCS ATCGKGTRMR
     YVSCRDDHGS VADEAACFHL PKPSATEACL VISCGRWKAM EWSSVSNFLV TRQILCVDYN
     DQSIDRNECD AEDILATEQD CSMPSCQQIN PGNRPANPFP YPDYHQKNNR GHPNRNQGHG
     HGGNQWRTGP WGACSSTCAG GFQRRVVVCQ DENGYAADNC DARMKPDELR SCESGPCPQW
     AYGSWSECTK SCGGGTRTRL VVCQHSNGER FTDLSCEILD KPPDREQCNM QDCPREAAWN
     AGPWSSCSVS CGRGQKYREV YCMSKDGKLL ENSLCTQLAK PNVLRKCRGG RCPKWKTGDW
     GQCSKTCGKG SRYRKLICVD QNMQEVDSLH CDPSKKPSDV EICTLPPCEY IWITGDWSEC
     SVTCGKGYKQ RLVSCSEIYT GKDHYEYGYQ NTVHCPGTPP PNVQSCYLGE CPVLASWRVG
     NWGSVCELPT SCKEAKRLKV ITEDGEYFLK VKGRLLKIYC AGMNSDSPKE YITLVNGDAE
     NFSEVYSYRL HNPTECPYNG SRRENCQCRK DYTAAGFSAF SKVRLDLNAM QIITTDLQFA
     QTLEGRPVPF ATAGDCYSAA KCPQDGTKVI GKCGGYCGKC TPSSGTGLDV QVL
//
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