ID V8P895_OPHHA Unreviewed; 2138 AA.
AC V8P895;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=Teneurin-1 {ECO:0000313|EMBL:ETE70206.1};
DE Flags: Fragment;
GN Name=ODZ1 {ECO:0000313|EMBL:ETE70206.1};
GN ORFNames=L345_03991 {ECO:0000313|EMBL:ETE70206.1};
OS Ophiophagus hannah (King cobra) (Naja hannah).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE70206.1, ECO:0000313|Proteomes:UP000018936};
RN [1] {ECO:0000313|EMBL:ETE70206.1, ECO:0000313|Proteomes:UP000018936}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Blood {ECO:0000313|EMBL:ETE70206.1};
RX PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., Dirks R.P.,
RA Spaink H.P., Duboule D., McGlinn E., Kini R.M., Richardson M.K.;
RT "The king cobra genome reveals dynamic gene evolution and adaptation in the
RT snake venom system.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004162};
CC Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004162}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETE70206.1}.
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DR EMBL; AZIM01000594; ETE70206.1; -; Genomic_DNA.
DR Proteomes; UP000018936; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 2.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.10.25.10; Laminin; 5.
DR Gene3D; 2.180.10.10; RHS repeat-associated core; 1.
DR InterPro; IPR008969; CarboxyPept-like_regulatory.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR009471; Ten_N.
DR InterPro; IPR028916; Tox-GHH_dom.
DR InterPro; IPR006530; YD.
DR NCBIfam; TIGR01643; YD_repeat_2x; 1.
DR PANTHER; PTHR11219; TENEURIN AND N-ACETYLGLUCOSAMINE-1-PHOSPHODIESTER ALPHA-N-ACETYLGLUCOSAMINIDASE; 1.
DR PANTHER; PTHR11219:SF7; TENEURIN-1; 1.
DR Pfam; PF06484; Ten_N; 1.
DR Pfam; PF15636; Tox-GHH; 1.
DR SMART; SM00181; EGF; 7.
DR SUPFAM; SSF49464; Carboxypeptidase regulatory domain-like; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF101898; NHL repeat; 1.
DR PROSITE; PS00022; EGF_1; 4.
DR PROSITE; PS01186; EGF_2; 3.
DR PROSITE; PS50026; EGF_3; 2.
DR PROSITE; PS51361; TENEURIN_N; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018936};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 142..163
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 47..142
FT /note="Teneurin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51361"
FT DOMAIN 417..449
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 563..598
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 1..66
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..51
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 439..448
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 567..577
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 588..597
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ETE70206.1"
SQ SEQUENCE 2138 AA; 239503 MW; A2F29F612BA52915 CRC64;
TAATSAATSP RVHLQPKASF SSQLPPSQIA DHPQPAESNP PQARPLTTRS QPNPAAPSPP
NTQDSVHLHN SWVLNSNIPL ETRHFLFKHG SGSSAIFSAA SQNYPLTSNT VYSPPPRPLP
RTTFSRPAFA FNKPYRCCNW KCTALSATAI TVTLALLLAY VIAVHLCGLT WHLQPVDGQL
YENGLSKGRF TESVDTTYAP IGGKVSDKTE RKDIVFQKGQ AIDTGEIDIG AQVMQTIPPG
LFWRFQITIH HPLYLKFNVS LAKDSLLGIY GRRNIPPTHT QFDFVKLMDG KQLIKQEPRH
FEESHQGPRN LILMSMQETG FIEYMDQGAW HMAFYNDGKK VEQVLMLTTA IEVMDDCSTN
CNGNGECISG HCHCFPGFLG PDCARDSCPV LCSGNGEYEQ GHCVCRNGWK GAECDVPEEQ
CIDPTCFGHG TCIMGICICV PGYKGEICEE EDCLDPMCSG HGVCVQGACH CSMGWGGVNC
ETSLPICQEQ CSGHGTFILE TGLCNCDPKW TGSDCSSGVC QCEEGWIGPT CEERTCNSHC
TEHGKCKDGK CECSPGWEGD HCTIDGCPGL CYGNGRCTLD QNGWHCVCQV GWSGMGCNVV
MEMLCEDNID NDGDGLTDCV DPDCCQQSNC FSSPLCQGSP DPLDLIQQSQ PPFLQHSPRL
FYDRIKFLIG KESTHVIQGD VLLESRRACV IRGQVVAVDG TPLVGVNVSF QHHSDFGYTI
SRQDGSFDLV AVGGISVTLI FDRSPFLPVK RTLWLAWNKF IVVDKVVMQR TEAEIPTCDL
SSFISPNPIV IPFPLTTFGG SCPERGTVVQ EEISFPSSFV KLSYLSSRTS GYKTLLRIIL
THSTIPPGIT KVHLTVTIEG RLAQKWFPAA INLIYTFAWN KTDIYGQKVS GLAEATVSVG
YEYESCPDLI LWEKRTVTLQ GFELDASNLG GWSLDKHHIL NTQRIVHKGN GENIFISQQP
AVVSTVMGNG HQRSVSCTNC NGPSHSSKLF APVALASGTD GSIYIGDFNF VRRLLPSGNS
ISILELSTQV LSCHGSGLRI PLFVGYKHQK GLQVTVEMED GPLKQLSTAH EVRLEWPTDL
AVNPLDNSLY DSDGHLTNAT FPTGEVSSFH SDVEKLMRIE IDASNRENVI TATNFSATST
IYTLKQDNIQ NIYRVSPDGS LRVTFASGME LMLNAETHIL AGVVNPTLGK CNISLPGEHN
SNLIEWRQRK EQTKGNISTF ERRLRAHNRN LLSIDFDHLT RTGKIYDDHR KFTLRILYDQ
AGRPILWSPI NKYNESVMLL LHSQRRYIFE HDQSDYLLSV TMPSMVRHSF QTMLSVGYYR
NLYSPPDSSA SFIQDFSRDG RLLQSFYPGT GRRVLYQYTP QSKLSEILYD TTQVSFTYEE
SSGVIKTIHL MHDGFICTIR YRQTGPLIGR QIFRFSEEGL VNARFDYSYN NFRVTSMQAM
INETPLPIDL YRYVDVSGKT EQFGKFSVIN YDLNQVITTT MMKHTKIFSA NGQVIEVQYE
ILKFIAYWMT IQYDNMGRMV ICDIRVGVNA NITRYFYEYD ADGQLQTVSV NDKTQWRYSY
DLNGNINLLS HGNSARLTPL RYDLRDRITR LGDLLYKVDE DGFLKQRGND IFEYSSNGFL
SRAYNRVSGW TVWFCYDGLG RRVASKSNLG QHLQFFYADL SNPVRITHLY NHSSSEITSL
YYDLQGNLIA MELSSGEEYY VACDNTGTPL AVFSSRGQVI KEILYTPYGE IYQDTNPDFE
VVIGFHGGLY NSLTKLVHLG QRDYDVIAGR WTSPNHRIWE ELKNVPKPFN LYAFENNYPA
GQIQDVAKYT TDIGSWLELF GFQLHNVLPG FPKPEMDAVD TTYELLQLQT KTQEWDPGKT
ILGIQCELQK QLRNFISLDQ LPMTPKYSDG QCTERAKQPQ FAAVPSVFGK GIKFAIKDGQ
VTADIIGVAN DDSRRIAAIL NGAHYLENLH FTIDGRDTHY FIKLGSLEED LSLIGNTGGR
RILENGVNVT VSQMTSVING RTRRFADIQL QHGFLCFNVR YGTTIEEEKN HVLEIARQRA
VLQAWTKEQK RLQDGEEGTR AWTEGEKQQL LSTGKVQGYD GYFVLSVEQY LELADSANNI
HFMRQSEIGR RTLCIYKYRG GKKHILLPLN VTEDGILI
//
