ID V8PAY2_OPHHA Unreviewed; 1698 AA.
AC V8PAY2;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE SubName: Full=Voltage-dependent R-type calcium channel subunit alpha-1E {ECO:0000313|EMBL:ETE71475.1};
DE Flags: Fragment;
GN Name=Cacna1e {ECO:0000313|EMBL:ETE71475.1};
GN ORFNames=L345_02706 {ECO:0000313|EMBL:ETE71475.1};
OS Ophiophagus hannah (King cobra) (Naja hannah).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE71475.1, ECO:0000313|Proteomes:UP000018936};
RN [1] {ECO:0000313|EMBL:ETE71475.1, ECO:0000313|Proteomes:UP000018936}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Blood {ECO:0000313|EMBL:ETE71475.1};
RX PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., Dirks R.P.,
RA Spaink H.P., Duboule D., McGlinn E., Kini R.M., Richardson M.K.;
RT "The king cobra genome reveals dynamic gene evolution and adaptation in the
RT snake venom system.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808}; Multi-
CC pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit (TC
CC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETE71475.1}.
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DR EMBL; AZIM01000358; ETE71475.1; -; Genomic_DNA.
DR Proteomes; UP000018936; Unassembled WGS sequence.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 6.10.250.2180; -; 1.
DR Gene3D; 6.10.250.2500; -; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 3.
DR InterPro; IPR031649; GPHH_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR014873; VDCC_a1su_IQ.
DR InterPro; IPR002077; VDCCAlpha1.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR45628; VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1; 1.
DR PANTHER; PTHR45628:SF5; VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E; 1.
DR Pfam; PF08763; Ca_chan_IQ; 1.
DR Pfam; PF16905; GPHH; 1.
DR Pfam; PF00520; Ion_trans; 3.
DR PRINTS; PR00167; CACHANNEL.
DR SMART; SM01062; Ca_chan_IQ; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 3.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PIRSR:PIRSR602077-1};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673,
KW ECO:0000256|RuleBase:RU003808};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568,
KW ECO:0000256|RuleBase:RU003808};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR602077-1};
KW Reference proteome {ECO:0000313|Proteomes:UP000018936};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU003808}.
FT TRANSMEM 143..163
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 169..187
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 208..226
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 685..704
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 716..737
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 752..772
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 816..838
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 941..959
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 971..994
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1065..1083
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1158..1182
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1319..1353
FT /note="Voltage-dependent calcium channel alpha-1 subunit
FT IQ"
FT /evidence="ECO:0000259|SMART:SM01062"
FT REGION 322..349
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 363..559
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 619..657
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1424..1587
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1649..1676
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 323..340
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 402..424
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 478..505
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 508..530
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 543..559
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 623..655
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1451..1509
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1510..1542
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 899
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ETE71475.1"
SQ SEQUENCE 1698 AA; 193900 MW; AD90DCD1A3D0A034 CRC64;
MFFCFQACNT KSSTFLLQRE FAKERERVEN RRAFMKLRRQ QQIERELNGY RAWIDKAEEV
MLAEENKNSG TSALEVLRRA TIKRNRTEAM NRDSSDERVD ISSVGTPLAR SSIKSAKLDG
ASYFRHKERL LRISVRHMVK SQVFYWLVLS IVALNTACVA IVHHKQPAWL THLLNYAEFI
FLGLFLLEMS LKMYGMGPRL YFHSSFNCFD CGVTVGSIFE VVWAIFRPGT SFGISVLRAL
RLLRIFKVTK FNFMDGTPSA NFDTFPAAIM TVFQDEQEEE EAFNQKHALQ KAKEVSPMSA
PNMPAIERER RRRHHMSVWE QRTSQLRRHM QMSSQEGINK DDPPLLNPNA SIFRKRKLLE
NSGLEKIEGD QGGRPEQTNG ESLEQKLPGS KPCPSIRDDQ RSPSPQAKRE WEEWHHKSFH
GNCDINDQES KGSVSFDDRA RLRQSQRRSR HRRVRTEPKE NRTVSQENGP EGVTPAKGEQ
NGDHKENGEE KETIAEKEPV ADMDLKRTSE ATANNAELPM PTQDPSPSEG HQMLDKSKEA
SPVKQDGSSL ETSEQALLGD LSMETERTIS RSEPDLSSIT ANMDKATEST TIMIDVQDST
VVQSKGLTRF VHFTVSNKTD GEASPLKEAE TKEEEEVEAE KKNKKRKKEK SSETGKPMVP
HSSMFIFSTT NPIRRACHYV VNLRYFEMCI LLVIAASSIA LAAEDPVLTN SDRNKVLRYF
DYVFTGVFTF EMVIKMIDQG LILQDGSYFR DLWNILDFIV VVGALMAFAL ASNKGRDIKT
IKSLRVLRVL RPLKTIKRLP KLKAVFDCVV TSLKNVFNIL IVYKLFMFIF AVIAVQLFKG
KFFYCTDSSK DTEKDCIGNY IDHEKNTMEV KCRQWKRHEF HYDNIIWALL TLFTVSTGEG
WPQACIDFAI SAKPLTRYMP QNRHTFQYRV WHFVVSPSFE YTIMAMIALN TVVLMMKYYS
APYTYELALK YLNIAFTMVF SLECVLKIIA FGFLNYFRDT WNIFDFITVI GSITEIILTD
SKPTVTSSFN MSFLKLFRAA RLIKLLRQGY TIRILLWTFV QSFKALPYVC LLIAMLFFIY
AIIGMQVFGN IKLDEESHIN RHNNFRSFLG SLMLLFRSAT GEAWQEIMLS CLEGKGCEPD
TTATSGQNEN EKCGTELAYV YFVSFIFFCS FLMLNLFVAV IMDNFEYLTR DSSILGPHHL
DEFVRIWAEY DRAACGRILY KDMYKLVRVI SPPLGLGEKC PCRVACKRLV LMNMPVAEDN
TVHFTSTLMA LIRTALDIKI AKGGADWQQL DSELQKEILT IWPHLSQKML DLLVPMPKTT
DLTVGKIYAA MMIMDYYKQS KAKKQRQQLE EQEPEIREFK RVQPSNCGSY LPVDTQERAV
SGRASSMPRL TMDPQVVTDP GSMRRSFSTI RDKRTNSSWL DEFSMERSSE NTYKSRRRSY
HSALHLSSRR LNTDSGHRSD THRSGGRERG RSKERRHLLS PDISRCNSEE RSPQADIDSP
ERHHSRSPSE GRSQTPNRQG TGSLSESSIP SLSDTSTPRR SHRQLPPVPP KPRPLISYTA
MMQHCGDTSP PPDDSEGGSP LLSGTLETNN TCLTESSSSL QGKQSLLSTP QRYISEPYLM
LQDDSHASDC GEEETLTFEA AVATSLGRSN TIASGPRSRH GWQMPNGHYR RRRRGASQSM
IYGAGIEVLS DTEEDDKC
//
