ID V8PB37_OPHHA Unreviewed; 574 AA.
AC V8PB37;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 24-JAN-2024, entry version 34.
DE SubName: Full=Myotubularin-related protein 6 {ECO:0000313|EMBL:ETE71530.1};
DE Flags: Fragment;
GN Name=MTMR6 {ECO:0000313|EMBL:ETE71530.1};
GN ORFNames=L345_02629 {ECO:0000313|EMBL:ETE71530.1};
OS Ophiophagus hannah (King cobra) (Naja hannah).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE71530.1, ECO:0000313|Proteomes:UP000018936};
RN [1] {ECO:0000313|EMBL:ETE71530.1, ECO:0000313|Proteomes:UP000018936}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Blood {ECO:0000313|EMBL:ETE71530.1};
RX PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., Dirks R.P.,
RA Spaink H.P., Duboule D., McGlinn E., Kini R.M., Richardson M.K.;
RT "The king cobra genome reveals dynamic gene evolution and adaptation in the
RT snake venom system.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class myotubularin subfamily. {ECO:0000256|ARBA:ARBA00007471}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETE71530.1}.
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DR EMBL; AZIM01000346; ETE71530.1; -; Genomic_DNA.
DR AlphaFoldDB; V8PB37; -.
DR Proteomes; UP000018936; Unassembled WGS sequence.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR010569; Myotubularin-like_Pase_dom.
DR InterPro; IPR030564; Myotubularin_fam.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR PANTHER; PTHR10807; MYOTUBULARIN-RELATED; 1.
DR PANTHER; PTHR10807:SF34; MYOTUBULARIN-RELATED PROTEIN 6; 1.
DR Pfam; PF06602; Myotub-related; 1.
DR Pfam; PF21098; PH-GRAM_MTMR6-like; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS51339; PPASE_MYOTUBULARIN; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000018936}.
FT DOMAIN 120..454
FT /note="Myotubularin phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS51339"
FT COILED 471..498
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 269..270
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR630564-2"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ETE71530.1"
SQ SEQUENCE 574 AA; 66695 MW; F0345027E7C2793C CRC64;
MTWQVEQVKL LDRFSTNIKS QTGTLYLTAT HLLFIDSSQK ETWILHHHIA AVEKLALTTS
GCPLVIQCKN FRIVHFIVPR ERDCHDIYNS LLQLSKPARY DELYAFSYNP KQNEEERVRG
WQIIDLTEEY DRMGVPNSEW QLSDANHNYK ICETYPRDLY VPRSASKPII VGSSKFRSKG
RFPVLSYYHK DNEATICRCS QPLSGFSARC LEDEHMLQAI SKTNPNNHYM YVMDTRPKLN
AMANRAAGKG YENEDNYSNI RFQFVGIENI HVMRSSLQKL LEVCGIRGLS VNDFLSGLES
SGWLRHIKAV LDAAIFLAKV LVEKDWIAFG HKFSDRCGQL DGDPKEISSV FAQFLECAWH
LTEQFPQAFE YNEAFLLQIH EHIHSCQFGN FIGNCQKERE ELKLKEKTFS LWPFLLDDRR
KYLNPIYNEH FSRSLSILEP DTVAFNFKFW RNMYHQFDHT MHPRQSVLSH VMSLSEQNKQ
LEKDIKELEN KLGHNLHKDL DAVFAKESVC PMSPGVKTSL CFKKEQPLLH ENDCVRTIEG
SNTADNRYSE YMEEFSKTEP TVVSLEYGVA KMTC
//
