ID V8PB69_OPHHA Unreviewed; 521 AA.
AC V8PB69;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Inhibitor of nuclear factor kappa-B kinase subunit alpha {ECO:0000313|EMBL:ETE71565.1};
DE Flags: Fragment;
GN Name=CHUK {ECO:0000313|EMBL:ETE71565.1};
GN ORFNames=L345_02618 {ECO:0000313|EMBL:ETE71565.1};
OS Ophiophagus hannah (King cobra) (Naja hannah).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE71565.1, ECO:0000313|Proteomes:UP000018936};
RN [1] {ECO:0000313|EMBL:ETE71565.1, ECO:0000313|Proteomes:UP000018936}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Blood {ECO:0000313|EMBL:ETE71565.1};
RX PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., Dirks R.P.,
RA Spaink H.P., Duboule D., McGlinn E., Kini R.M., Richardson M.K.;
RT "The king cobra genome reveals dynamic gene evolution and adaptation in the
RT snake venom system.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETE71565.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AZIM01000343; ETE71565.1; -; Genomic_DNA.
DR AlphaFoldDB; V8PB69; -.
DR Proteomes; UP000018936; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProt.
DR CDD; cd17046; Ubl_IKKA_like; 1.
DR Gene3D; 1.20.1270.250; -; 1.
DR InterPro; IPR041185; IKBKB_SDD.
DR InterPro; IPR046375; IKBKB_SDD_sf.
DR PANTHER; PTHR22969; IKB KINASE; 1.
DR PANTHER; PTHR22969:SF13; INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA; 1.
DR Pfam; PF18397; IKBKB_SDD; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:ETE71565.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000018936};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 181..454
FT /note="IKBKB scaffold dimerization"
FT /evidence="ECO:0000259|Pfam:PF18397"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ETE71565.1"
SQ SEQUENCE 521 AA; 59242 MW; 70AE2B0FD0C4A12F CRC64;
MKENPGPLWT PSTCFFLFGA GASARHEKIK RKDPKCIFAW EEMTGEVRFS AYLPTPNSLC
STIVESMEPW LQMMLTWDPQ QRGGGMDPNT NSYRCFQVME RLLSLKIVHI LNMTSAKILS
YSLHPEESLH SLQVRIESDT GISLGNQELL LEMGSCLDPR KPASQCVIDG VKGWDSYMVY
LFDKSKTTYE GPFASRTLSD SVNYIVKDSK IQLPVFQLRK IWAEAVHYVI GLRDDYSRLF
QGQRAAMLSL LRYNTNLTNR KNNMISASQQ LKAKLNFFQQ SIHLDLERYS DQMTYGISSE
KMLKAWKDME EKASLCEKVA DIGSLDEQIM ALHTEIVELQ RSLHVRRQND VMENLEQRAI
ELYKQLKSRP PDHVYSDSTE MVRIIVQTVQ SQDLVLKELF RHLSKLLGCK QKIIDLLPSI
DVALNSIKEA DNSVMQMQGK RQREIWHLLK IACTQSSARS ASSSVDGPVP SSVPAWLPQT
AQAHVLQPLP FVEASRNAVS TGVGWISASD VAHPYLQKWA F
//