ID V8PD63_OPHHA Unreviewed; 169 AA.
AC V8PD63;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 22-FEB-2023, entry version 20.
DE SubName: Full=Sphingosine kinase 1 {ECO:0000313|EMBL:ETE72469.1};
DE Flags: Fragment;
GN Name=SPHK1 {ECO:0000313|EMBL:ETE72469.1};
GN ORFNames=L345_01682 {ECO:0000313|EMBL:ETE72469.1};
OS Ophiophagus hannah (King cobra) (Naja hannah).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE72469.1, ECO:0000313|Proteomes:UP000018936};
RN [1] {ECO:0000313|EMBL:ETE72469.1, ECO:0000313|Proteomes:UP000018936}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Blood {ECO:0000313|EMBL:ETE72469.1};
RX PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., Dirks R.P.,
RA Spaink H.P., Duboule D., McGlinn E., Kini R.M., Richardson M.K.;
RT "The king cobra genome reveals dynamic gene evolution and adaptation in the
RT snake venom system.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETE72469.1}.
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DR EMBL; AZIM01000219; ETE72469.1; -; Genomic_DNA.
DR AlphaFoldDB; V8PD63; -.
DR Proteomes; UP000018936; Unassembled WGS sequence.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR InterPro; IPR017438; ATP-NAD_kinase_N.
DR InterPro; IPR001206; Diacylglycerol_kinase_cat_dom.
DR InterPro; IPR016064; NAD/diacylglycerol_kinase_sf.
DR PANTHER; PTHR12358; SPHINGOSINE KINASE; 1.
DR PANTHER; PTHR12358:SF47; SPHINGOSINE KINASE 1; 1.
DR Pfam; PF00781; DAGK_cat; 1.
DR SUPFAM; SSF111331; NAD kinase/diacylglycerol kinase-like; 1.
DR PROSITE; PS50146; DAGK; 1.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:ETE72469.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000018936};
KW Transferase {ECO:0000313|EMBL:ETE72469.1}.
FT DOMAIN 57..127
FT /note="DAGKc"
FT /evidence="ECO:0000259|PROSITE:PS50146"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ETE72469.1"
SQ SEQUENCE 169 AA; 18798 MW; 5AC235A86511814B CRC64;
MVGLQFLDLL SQHVMLTVNL FTLLILGRRN TWVTSSEVSG DSAAEPTEWS RRGPASIYLS
KKHNHAWDLA REEDMSKWDA VVIMAGDGLL HEVINGLMER PDWKTAIQKP LCILPGGSGN
ALAASLNHYA RQTLHLKFCS EHSDSYAAFF IAHHQPKAYD NPTWSSIGA
//
