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Database: UniProt
Entry: V8PDA6_OPHHA
LinkDB: V8PDA6_OPHHA
Original site: V8PDA6_OPHHA 
ID   V8PDA6_OPHHA            Unreviewed;       299 AA.
AC   V8PDA6;
DT   19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT   19-FEB-2014, sequence version 1.
DT   31-JUL-2019, entry version 23.
DE   SubName: Full=G protein-activated inward rectifier potassium channel 1 {ECO:0000313|EMBL:ETE71892.1};
DE   Flags: Fragment;
GN   Name=Kcnj3 {ECO:0000313|EMBL:ETE71892.1};
GN   ORFNames=L345_02282 {ECO:0000313|EMBL:ETE71892.1};
OS   Ophiophagus hannah (King cobra) (Naja hannah).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata;
OC   Toxicofera; Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX   NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE71892.1};
RN   [1] {ECO:0000313|EMBL:ETE71892.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Blood {ECO:0000313|EMBL:ETE71892.1};
RX   PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA   Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA   McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA   Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA   de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA   Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA   Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W.,
RA   Dirks R.P., Spaink H.P., Duboule D., McGlinn E., Kini R.M.,
RA   Richardson M.K.;
RT   "The king cobra genome reveals dynamic gene evolution and adaptation
RT   in the snake venom system.";
RL   Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003822};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003822}.
CC   -!- SIMILARITY: Belongs to the inward rectifier-type potassium channel
CC       (TC 1.A.2.1) family. {ECO:0000256|RuleBase:RU003822}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:ETE71892.1}.
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DR   EMBL; AZIM01000296; ETE71892.1; -; Genomic_DNA.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015467; F:G-protein activated inward rectifier potassium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.1400; -; 1.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR041647; IRK_C.
DR   InterPro; IPR016449; K_chnl_inward-rec_Kir.
DR   InterPro; IPR003274; K_chnl_inward-rec_Kir3.1.
DR   InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
DR   InterPro; IPR040445; Kir_TM.
DR   PANTHER; PTHR11767; PTHR11767; 1.
DR   Pfam; PF01007; IRK; 1.
DR   Pfam; PF17655; IRK_C; 1.
DR   PIRSF; PIRSF005465; GIRK_kir; 1.
DR   PRINTS; PR01327; KIR31CHANNEL.
DR   PRINTS; PR01320; KIRCHANNEL.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   3: Inferred from homology;
KW   Ion channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434609, ECO:0000313|EMBL:ETE71892.1};
KW   Ion transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434639};
KW   Membrane {ECO:0000256|SAAS:SAAS00434581, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434575};
KW   Potassium transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434641};
KW   Transmembrane {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434543, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00036756,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00036755};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00048561}.
FT   TRANSMEM     77    101       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    151    175       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       40    180       IRK. {ECO:0000259|Pfam:PF01007}.
FT   DOMAIN      187    299       IRK_C. {ECO:0000259|Pfam:PF17655}.
FT   REGION       17     38       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   SITE        166    166       Role in the control of polyamine-mediated
FT                                channel gating and in the blocking by
FT                                intracellular magnesium.
FT                                {ECO:0000256|PIRSR:PIRSR005465-1}.
FT   NON_TER       1      1       {ECO:0000313|EMBL:ETE71892.1}.
FT   NON_TER     299    299       {ECO:0000313|EMBL:ETE71892.1}.
SQ   SEQUENCE   299 AA;  34228 MW;  522B4001ED2BB331 CRC64;
     MSALRRKFGD DYQVVTTSSS GSGFHQQQGS AHKKKRQRFV DKNGRCNVQH GNLGSETSRY
     LSDLFTTLVD LKWRWNLFIF ILTYTVAWLF MASMWWVIAY MRGDLNKAHD EKYTPCVANV
     YNFPSAFLFF IETEATIGYG YRYITDKCPE GIILFLFQSI LGSIVDAFLI GCMFIKMSQP
     KKRAETLMFS EHAAISMRDG KLTLMFRVGN LRNSHMVSAQ IRCKLLKSRQ TPEGEFLPLD
     QLELDVGFST GADQLFLVSP LTICHVIDSK SPFYDLSQRS MQTEQFEIVV ILEGIVETT
//
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