ID V8PDM4_OPHHA Unreviewed; 2386 AA.
AC V8PDM4;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=Voltage-dependent T-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
DE Flags: Fragment;
GN Name=Cacna1h {ECO:0000313|EMBL:ETE72455.1};
GN ORFNames=L345_01712 {ECO:0000313|EMBL:ETE72455.1};
OS Ophiophagus hannah (King cobra) (Naja hannah).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE72455.1, ECO:0000313|Proteomes:UP000018936};
RN [1] {ECO:0000313|EMBL:ETE72455.1, ECO:0000313|Proteomes:UP000018936}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Blood {ECO:0000313|EMBL:ETE72455.1};
RX PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., Dirks R.P.,
RA Spaink H.P., Duboule D., McGlinn E., Kini R.M., Richardson M.K.;
RT "The king cobra genome reveals dynamic gene evolution and adaptation in the
RT snake venom system.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry
CC of calcium ions into excitable cells and are also involved in a variety
CC of calcium-dependent processes, including muscle contraction, hormone
CC or neurotransmitter release, gene expression, cell motility, cell
CC division and cell death. This channel gives rise to T-type calcium
CC currents. T-type calcium channels belong to the "low-voltage activated
CC (LVA)" group and are strongly blocked by nickel and mibefradil. A
CC particularity of this type of channels is an opening at quite negative
CC potentials, and a voltage-dependent inactivation. T-type channels serve
CC pacemaking functions in both central neurons and cardiac nodal cells
CC and support calcium signaling in secretory cells and vascular smooth
CC muscle. They may also be involved in the modulation of firing patterns
CC of neurons which is important for information processing as well as in
CC cell growth processes. {ECO:0000256|RuleBase:RU003808}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body
CC {ECO:0000256|ARBA:ARBA00004120}. Membrane
CC {ECO:0000256|RuleBase:RU003808}; Multi-pass membrane protein
CC {ECO:0000256|RuleBase:RU003808}.
CC -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit (TC
CC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETE72455.1}.
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DR EMBL; AZIM01000222; ETE72455.1; -; Genomic_DNA.
DR Proteomes; UP000018936; Unassembled WGS sequence.
DR GO; GO:0005929; C:cilium; IEA:UniProt.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR GO; GO:0030030; P:cell projection organization; IEA:UniProtKB-KW.
DR Gene3D; 1.10.287.70; -; 3.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 3.
DR InterPro; IPR010796; C2_B9-type_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR005445; VDCC_T_a1.
DR InterPro; IPR002077; VDCCAlpha1.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10037:SF192; VOLTAGE-DEPENDENT T-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1H; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF07162; B9-C2; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR PRINTS; PR00167; CACHANNEL.
DR PRINTS; PR01629; TVDCCALPHA1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 3.
DR PROSITE; PS51381; C2_B9; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PIRSR:PIRSR602077-1};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673,
KW ECO:0000256|RuleBase:RU003808};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568,
KW ECO:0000256|RuleBase:RU003808};
KW Cilium biogenesis/degradation {ECO:0000256|ARBA:ARBA00022794};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Ion channel {ECO:0000256|RuleBase:RU003808};
KW Ion transport {ECO:0000256|ARBA:ARBA00022568,
KW ECO:0000256|RuleBase:RU003808};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR602077-1};
KW Reference proteome {ECO:0000313|Proteomes:UP000018936};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022568, ECO:0000256|RuleBase:RU003808};
KW Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT TRANSMEM 863..883
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 946..968
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1023..1046
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1327..1347
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1359..1380
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1450..1472
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1567..1593
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1649..1668
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1715..1734
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1806..1827
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1900..1921
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 824..1052
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1287..1404
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1426..1603
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1649..1931
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 248..267
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 272..302
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 548..576
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 651..686
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2120..2182
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2206..2259
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1602..1629
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 252..267
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2236..2258
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 1005
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ETE72455.1"
SQ SEQUENCE 2386 AA; 267231 MW; FE04A382FD798436 CRC64;
TWEAGCVSQK QHLRFSLTLV SHLVRARQHA GYPLELRHPW DVPAMSGYQV PNRKVHNLGG
KRDVSLCPCG LGPLVAYGGA NAVLFLTSRV SLLLSLSPSM MEYSLDGHNV SLSAIRTVRV
LRPLRAINRV PSKTHNLTFL HKYYRPEESE ENPFICSSLR DNGMQKCSSI PNRKEYKMDC
TLTVDAYNPQ LDSLDLSSRN GCINWNQYYN VCRTGDLNPH NGAINFDNIG YAWIAIFQPS
ALPHPLDSCG TANLGQPESQ SWHSTDQTLH LWQEKPDLRN PRRKQRKPPP SPISWGPSAR
SSSERLERSS HLFLQLFQQS DEKPILGRRG MVTEGKPWRG TKACRRCLGF PYKMPPSSGF
PAQLGGGGGG GGGEAFRAAQ LLPNELNRVL RSKLNPAEVL KIFQVDWGLQ CPGPKASPGK
ATWHSLPPSC HLDYRVVVDI LCNQTVHQHK DCVKEWLPHL RLGICKVGSF FMINLCLVVI
ATQFSETKQR ENQLMQEQRA RYLSNDSTIA SFSEPGSCYE ELLKYICHIF RKVKRRALRL
YNNWQSKRRK KVNPNSGADD VQGHQSGKRR IMSIQGPRAN PGICDLELDV MKPGSQLMLP
PSSPSHPSGG AADTESIHSI YHADCHVEGT SVKCKSSSIA AGSKAANRSS MNYPTILPSP
ANKASVPPLS KGKKNEGSEA TSPMPVVSSP AHLNADCYGK LHHLVGERGL CRTSSILSGL
NVPCPLPGPQ ANTLSCELQN CPFCASILED PEFEFSEADS YESGEDNNGV YEFTQDVKHG
DLRDQIQQQR NKKKKKRKPA KERNKITKLW KAFGNKLKRI VESKYFNRGI MIAILINTLS
MGIEYHEQPD ELTNALEISN IVFTSMFALE MLLKLLAFGI WGYIKNPYNI FDGIIVVISV
WEIIGQADGG LSVLRTFRLL RVLKLVRFMP ALRRQLVVLM KTMDNVATFC MLLMLFIFIF
SILGMHLFGC KFGLRTETGD TMPDRKNFDS LLWAIVTVFQ ILTQEDWNVV LYNGMASTSS
WAALYFVALM TFGNYVLFNL LVAILVEGFQ AEGDANRSDT DEDKTSTNFE EEFEKLKELH
ASEMKMYSLA VTPNGHLEGK GSMPPPIIMH TAATPMPTPK GSPHMDSAYP FGDSRRGSNV
SVDPLGFDQK SLVFSQEGAR LAGLGRGGKG ERSLSGAESL DCRGALDLPE LLQVPGVHPP
VAMLPLEYQD CNGKMLQVPS ELYLHLDGRK EDPFDYDDNM EDSFCYRIRK SLEPYKPKWC
KNHEDWSLYL FSPQNRLRAN CQKVIAHKMF DHIVLVFIFL NCITIALERP DIDPNSTERI
FLSVSNYIFT AIFVAEMMVK VVALGFFSGE HTYLQSSWNV LDGILVFVSI IDIIVSMASA
GGAKILGVLR VLRLLRTLRP LRFLWEDCMF LGEPGNGMKP GGVPLLSRVI SRAPGLKLVV
ETLISSLRPI GNIVLICCAF FIIFGILGVQ LFKGKFYHCE GVDIRNISTK TDCRKAHYKW
VRRKYNFDNL GQASLLPQAL MSLFVLSSKD GWVNIMYDGL DAVGIDQQVD TKYPKKFSWG
PSRNHNLWML LYFISFLLIV SFFVLNMFVG VVVENFHKCR QHQEAEEARR REEKRLRRLE
KKRRKAQRRP YYADYSPARK YIHSLCTSHY LDLFITFIIG VNVITMSMEH FDQPKGRSCT
SIPFARSSMD PNKQPPPNSC VSLQSLEEAL KYCNYLFTFV FVVEAILKLV AFGFRRFFKD
RWNQLDLAIV LLSIMGITLE EIEMNAALPI NPTIIRIMRV LRIARVLKLL KMATGMRALL
DTVVQALPQV GNLGLLFMLL FFIYAALGVE LFGKLDCSEE NPCEGLSRHA TFNNFGMAFL
TLFRVSTGDN WNGIMKDTLR ECHRDDKHCL SYLPVISPVY FVTFVLIAQF VLVNVVVAVL
MKHLEESNKE AKEDAEMDAE IELEMSRGVS TPERTMDGQQ TPSKGGSPLL VKHHVMGASA
AGLRDPQNLL TLRKISVARM HSLPNDSYMF RPVMPAKPPF PLHEGELEAF SCKSPRGSVT
SIHSQPVVTS SLRIPQLAFR PTTPPPSHNM GAPWKLLPPR PALRTPSFSR LLCRQVSFPV
SRCSLVGEER QKVALERAEE TKELVPNRKS EPETQQLEVL PAAAAPHPSG RPGGLKIWGP
SLLRRCGRRP RPEPPTGASG RRQFPEFDEL YCKYCFVYGP DWAPTTVGPP SGKGIPPTGA
TTREAWKKAS HRSRPKAGTS NKTWSGTSPS TSPSKAPTPL AVGPQIVVSV YGPDLFGNDV
VRGYGAVHVP FTPGRHQRIL PMFVPESTSR LQKLTSWLTG RYPEFTDPKV VAQGEGREVT
RVRSQGFVTV SFNVVTKDMK KLGYDVSSPT LASSSLTSVT DAMYKF
//
