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Database: UniProt
Entry: V8PDN2_OPHHA
LinkDB: V8PDN2_OPHHA
Original site: V8PDN2_OPHHA 
ID   V8PDN2_OPHHA            Unreviewed;       423 AA.
AC   V8PDN2;
DT   19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT   19-FEB-2014, sequence version 1.
DT   31-JUL-2019, entry version 25.
DE   SubName: Full=G protein-activated inward rectifier potassium channel 3 {ECO:0000313|EMBL:ETE72061.1};
DE   Flags: Fragment;
GN   Name=Kcnj9 {ECO:0000313|EMBL:ETE72061.1};
GN   ORFNames=L345_02111 {ECO:0000313|EMBL:ETE72061.1};
OS   Ophiophagus hannah (King cobra) (Naja hannah).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata;
OC   Toxicofera; Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX   NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE72061.1};
RN   [1] {ECO:0000313|EMBL:ETE72061.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Blood {ECO:0000313|EMBL:ETE72061.1};
RX   PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA   Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA   McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA   Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA   de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA   Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA   Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W.,
RA   Dirks R.P., Spaink H.P., Duboule D., McGlinn E., Kini R.M.,
RA   Richardson M.K.;
RT   "The king cobra genome reveals dynamic gene evolution and adaptation
RT   in the snake venom system.";
RL   Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003822};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003822}.
CC   -!- SIMILARITY: Belongs to the inward rectifier-type potassium channel
CC       (TC 1.A.2.1) family. {ECO:0000256|RuleBase:RU003822}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:ETE72061.1}.
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DR   EMBL; AZIM01000274; ETE72061.1; -; Genomic_DNA.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015467; F:G-protein activated inward rectifier potassium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.1400; -; 1.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR041647; IRK_C.
DR   InterPro; IPR016449; K_chnl_inward-rec_Kir.
DR   InterPro; IPR003276; K_chnl_inward-rec_Kir3.3.
DR   InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
DR   InterPro; IPR040445; Kir_TM.
DR   PANTHER; PTHR11767; PTHR11767; 1.
DR   PANTHER; PTHR11767:SF17; PTHR11767:SF17; 1.
DR   Pfam; PF01007; IRK; 1.
DR   Pfam; PF17655; IRK_C; 1.
DR   PIRSF; PIRSF005465; GIRK_kir; 1.
DR   PRINTS; PR01320; KIRCHANNEL.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   3: Inferred from homology;
KW   Ion channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434609, ECO:0000313|EMBL:ETE72061.1};
KW   Ion transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434639};
KW   Membrane {ECO:0000256|SAAS:SAAS00434581, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434575};
KW   Potassium transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434641};
KW   Transmembrane {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434543, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00036756,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00036755};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00048561}.
FT   TRANSMEM     89    112       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    132    150       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    171    196       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       53    199       IRK. {ECO:0000259|Pfam:PF01007}.
FT   DOMAIN      206    376       IRK_C. {ECO:0000259|Pfam:PF17655}.
FT   REGION        1     47       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION      395    423       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   SITE        185    185       Role in the control of polyamine-mediated
FT                                channel gating and in the blocking by
FT                                intracellular magnesium.
FT                                {ECO:0000256|PIRSR:PIRSR005465-1}.
FT   NON_TER       1      1       {ECO:0000313|EMBL:ETE72061.1}.
SQ   SEQUENCE   423 AA;  47670 MW;  E943F95F5685BD9D CRC64;
     MAKDNPAFSA IPKTPVSEGK ASLSSQPGKS AALRRLGEGP EKVEKKRGRQ RYVEKDGKCN
     VQHGNVRETY RYLTDIFTTL VDLKWRFSLL VFILAYAVTW LFFGLIWWFI AYCRGDLDHL
     GDDAWTPCVN NLNGFVSAFL GFVSAFLFSI ETETTIGYGH RVITDKCPEG IVLLLLQAIL
     GSMVNAFMVG CMFVKISQPN KRAETLVFSS HAVISLRDDH LCLMFRVGDL RNSHIVEASI
     RAKLIKSKQT QEGEFIPLNQ TDISVGFETG DDRLFLVSPL IISHEINQQS PFWEVSKEQL
     QKDEFEIVVI LEGMVEATGM TCQARSSYLV DEVLWGHRFM SVLSLEDGFY EVDYNSFHQT
     FEVPTPSCSA RELAEAAARM DAHLYWSIPS QLDEKVEEGT EKGDKVDKER NGNLTSTESE
     SKV
//
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