ID V8PDY1_OPHHA Unreviewed; 503 AA.
AC V8PDY1;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE SubName: Full=Protein kinase C and casein kinase substrate in neurons protein 3 {ECO:0000313|EMBL:ETE72161.1};
DE Flags: Fragment;
GN Name=PACSIN3 {ECO:0000313|EMBL:ETE72161.1};
GN ORFNames=L345_02018 {ECO:0000313|EMBL:ETE72161.1};
OS Ophiophagus hannah (King cobra) (Naja hannah).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE72161.1, ECO:0000313|Proteomes:UP000018936};
RN [1] {ECO:0000313|EMBL:ETE72161.1, ECO:0000313|Proteomes:UP000018936}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Blood {ECO:0000313|EMBL:ETE72161.1};
RX PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., Dirks R.P.,
RA Spaink H.P., Duboule D., McGlinn E., Kini R.M., Richardson M.K.;
RT "The king cobra genome reveals dynamic gene evolution and adaptation in the
RT snake venom system.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETE72161.1}.
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DR EMBL; AZIM01000265; ETE72161.1; -; Genomic_DNA.
DR AlphaFoldDB; V8PDY1; -.
DR Proteomes; UP000018936; Unassembled WGS sequence.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 2.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR031160; F_BAR.
DR InterPro; IPR001060; FCH_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23065; PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1; 1.
DR PANTHER; PTHR23065:SF18; PROTEIN KINASE C AND CASEIN KINASE SUBSTRATE IN NEURONS PROTEIN 3; 1.
DR Pfam; PF00611; FCH; 1.
DR SMART; SM00055; FCH; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 2.
DR PROSITE; PS51741; F_BAR; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|PROSITE-ProRule:PRU01077};
KW Kinase {ECO:0000313|EMBL:ETE72161.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000018936};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Transferase {ECO:0000313|EMBL:ETE72161.1}.
FT DOMAIN 46..234
FT /note="F-BAR"
FT /evidence="ECO:0000259|PROSITE:PS51741"
FT DOMAIN 438..503
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 191..221
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 330..374
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 191..208
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ETE72161.1"
SQ SEQUENCE 503 AA; 57386 MW; 6CA543365ACBA81A CRC64;
HIDQEEPQGF PAHPGIGPAF GAPNFANILC CKETRVMSAE DDTGGEAPSG SFWEPGNYKR
TVKRVDDGNR LCNDLVSCFQ ERAKIEKSYA QQLTDWSRKW RTSVEKGPQY GTLEKAWHAF
LTAADKLSEI HLEVRNRLSG EDSEKIKAWQ KEVYHKQLMG GFRETKEVED GFRKAQKPWV
KKLKEVESSK KNYHVARKEE KTAQTRDNHA KADTSTSQEQ LRKLQERVEK CSQEVEKDME
QVFEGCQEAE CRRLCFFKEM FLDMHNHLNL SVNDRFHALY RDLHQGIMAA DDQEDLKWWR
STHGPGMAMH WPQFEEWSLE SQRAIVKKEK SGKSGEDVTL TSIVPSGDGV KETPPSTKQS
GGKEEISEWS DEDTPKKCLE VNGHEEDIKV PGVRVRALYD YAGQEADELS FKAVLVSNDL
GFCVIQECSL AHSRKNRNKE IKAQACCPHD RLDAGIFGQQ LAMPGREELM KISEEDEQGW
CKGRLQTGQV GLYPANYVEK VIL
//
