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Database: UniProt
Entry: V8PE32_OPHHA
LinkDB: V8PE32_OPHHA
Original site: V8PE32_OPHHA 
ID   V8PE32_OPHHA            Unreviewed;       452 AA.
AC   V8PE32;
DT   19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT   19-FEB-2014, sequence version 1.
DT   31-JUL-2019, entry version 25.
DE   SubName: Full=Inward rectifier potassium channel 4 {ECO:0000313|EMBL:ETE72824.1};
DE   Flags: Fragment;
GN   Name=KCNJ4 {ECO:0000313|EMBL:ETE72824.1};
GN   ORFNames=L345_01333 {ECO:0000313|EMBL:ETE72824.1};
OS   Ophiophagus hannah (King cobra) (Naja hannah).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata;
OC   Toxicofera; Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX   NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE72824.1};
RN   [1] {ECO:0000313|EMBL:ETE72824.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Blood {ECO:0000313|EMBL:ETE72824.1};
RX   PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA   Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA   McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA   Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA   de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA   Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA   Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W.,
RA   Dirks R.P., Spaink H.P., Duboule D., McGlinn E., Kini R.M.,
RA   Richardson M.K.;
RT   "The king cobra genome reveals dynamic gene evolution and adaptation
RT   in the snake venom system.";
RL   Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003822};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003822}.
CC   -!- SIMILARITY: Belongs to the inward rectifier-type potassium channel
CC       (TC 1.A.2.1) family. {ECO:0000256|RuleBase:RU003822}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:ETE72824.1}.
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DR   EMBL; AZIM01000174; ETE72824.1; -; Genomic_DNA.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005242; F:inward rectifier potassium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.1400; -; 1.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR041647; IRK_C.
DR   InterPro; IPR016449; K_chnl_inward-rec_Kir.
DR   InterPro; IPR003273; K_chnl_inward-rec_Kir2.3.
DR   InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
DR   InterPro; IPR013673; K_chnl_inward-rec_Kir_N.
DR   InterPro; IPR040445; Kir_TM.
DR   PANTHER; PTHR11767; PTHR11767; 1.
DR   PANTHER; PTHR11767:SF53; PTHR11767:SF53; 1.
DR   Pfam; PF01007; IRK; 1.
DR   Pfam; PF17655; IRK_C; 1.
DR   Pfam; PF08466; IRK_N; 1.
DR   PRINTS; PR01326; KIR23CHANNEL.
DR   PRINTS; PR01320; KIRCHANNEL.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   3: Inferred from homology;
KW   Ion channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434609, ECO:0000313|EMBL:ETE72824.1};
KW   Ion transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434639};
KW   Membrane {ECO:0000256|SAAS:SAAS00434581, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434575};
KW   Potassium transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434641};
KW   Transmembrane {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434543, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00036756,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00036755};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00048561}.
FT   TRANSMEM     83    109       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    162    187       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN        1     47       IRK_N. {ECO:0000259|Pfam:PF08466}.
FT   DOMAIN       48    192       IRK. {ECO:0000259|Pfam:PF01007}.
FT   DOMAIN      199    371       IRK_C. {ECO:0000259|Pfam:PF17655}.
FT   REGION       20     44       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   NON_TER       1      1       {ECO:0000313|EMBL:ETE72824.1}.
SQ   SEQUENCE   452 AA;  51172 MW;  DF64EA699074BD55 CRC64;
     MGSIRVNRYS IVSTEEDGHK VSSLGSLNEH SRNGKGHAPR RKRRNRFVKK NGQCNVYFAN
     LSNKSQRYMA DIFTTCVDTR WRYMLMIFSA AFLVSWLFFG LLFWIIAFFH GDLDVPGTGS
     GSVATKFCIK HVNGFLGAFL FSVETQTTIG YGFRYVTEEC PLAIMVVVVQ SIVGCVIDSF
     MIGTIMAKMA RPKKRAQTLL FSHHAVISLR DGKLCLMWRV GNLRRSHIVE AHVRAQLIKP
     YMTAEGEYLP LDQRDLNVGY DIGLDRIFLV SPIIIVHEID EESPLYGMGK EELEREDFEI
     VVILEGMVEA TAMTTQARSS YLASEILWGH RFEPVVFEEK KHYKVDYSRF HKTYEVAGTP
     YCSARELQES KITILPSPPP PPSAFCYENE LALVSQDEDE EDDLDVGVDL GGDPKDDAGV
     IPMMEFGSHM DLDRLQVSIP LDALSYRRES AI
//
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