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Database: UniProt
Entry: V8PE56_OPHHA
LinkDB: V8PE56_OPHHA
Original site: V8PE56_OPHHA 
ID   V8PE56_OPHHA            Unreviewed;      3053 AA.
AC   V8PE56;
DT   19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT   19-FEB-2014, sequence version 1.
DT   05-JUN-2019, entry version 31.
DE   SubName: Full=DNA polymerase zeta catalytic subunit {ECO:0000313|EMBL:ETE72844.1};
DE   Flags: Fragment;
GN   Name=REV3L {ECO:0000313|EMBL:ETE72844.1};
GN   ORFNames=L345_01316 {ECO:0000313|EMBL:ETE72844.1};
OS   Ophiophagus hannah (King cobra) (Naja hannah).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata;
OC   Toxicofera; Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX   NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE72844.1};
RN   [1] {ECO:0000313|EMBL:ETE72844.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Blood {ECO:0000313|EMBL:ETE72844.1};
RX   PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA   Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA   McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA   Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA   de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA   Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA   Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W.,
RA   Dirks R.P., Spaink H.P., Duboule D., McGlinn E., Kini R.M.,
RA   Richardson M.K.;
RT   "The king cobra genome reveals dynamic gene evolution and adaptation
RT   in the snake venom system.";
RL   Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:ETE72844.1}.
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DR   EMBL; AZIM01000172; ETE72844.1; -; Genomic_DNA.
DR   GO; GO:0016035; C:zeta DNA polymerase complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:InterPro.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0019985; P:translesion synthesis; IEA:InterPro.
DR   Gene3D; 1.10.132.60; -; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.90.1600.10; -; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR   InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR042087; DNA_pol_B_C.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR032757; DUF4683.
DR   InterPro; IPR030559; PolZ_Rev3.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR025687; Znf-C4pol.
DR   PANTHER; PTHR45812; PTHR45812; 2.
DR   Pfam; PF00136; DNA_pol_B; 1.
DR   Pfam; PF03104; DNA_pol_B_exo1; 2.
DR   Pfam; PF15735; DUF4683; 1.
DR   Pfam; PF14260; zf-C4pol; 1.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils}.
FT   DOMAIN       26    162       DNA_pol_B_exo1. {ECO:0000259|Pfam:
FT                                PF03104}.
FT   DOMAIN      666   1054       DUF4683. {ECO:0000259|Pfam:PF15735}.
FT   DOMAIN     2134   2425       DNA_pol_B_exo1. {ECO:0000259|Pfam:
FT                                PF03104}.
FT   DOMAIN     2492   2923       DNA_pol_B. {ECO:0000259|Pfam:PF00136}.
FT   DOMAIN     2965   3032       zf-C4pol. {ECO:0000259|Pfam:PF14260}.
FT   REGION      370    395       Disordered. {ECO:0000256|MobiDB-lite:
FT                                V8PE56}.
FT   REGION      409    445       Disordered. {ECO:0000256|MobiDB-lite:
FT                                V8PE56}.
FT   REGION      959    983       Disordered. {ECO:0000256|MobiDB-lite:
FT                                V8PE56}.
FT   REGION     1107   1139       Disordered. {ECO:0000256|MobiDB-lite:
FT                                V8PE56}.
FT   REGION     1466   1511       Disordered. {ECO:0000256|MobiDB-lite:
FT                                V8PE56}.
FT   REGION     1660   1680       Disordered. {ECO:0000256|MobiDB-lite:
FT                                V8PE56}.
FT   REGION     1757   1784       Disordered. {ECO:0000256|MobiDB-lite:
FT                                V8PE56}.
FT   REGION     2027   2081       Disordered. {ECO:0000256|MobiDB-lite:
FT                                V8PE56}.
FT   REGION     2264   2284       Disordered. {ECO:0000256|MobiDB-lite:
FT                                V8PE56}.
FT   COILED     2988   3008       {ECO:0000256|SAM:Coils}.
FT   COMPBIAS    416    436       Polyampholyte. {ECO:0000256|MobiDB-lite:
FT                                V8PE56}.
FT   COMPBIAS    965    983       Basic. {ECO:0000256|MobiDB-lite:V8PE56}.
FT   COMPBIAS   1119   1138       Basic. {ECO:0000256|MobiDB-lite:V8PE56}.
FT   COMPBIAS   1466   1482       Polar. {ECO:0000256|MobiDB-lite:V8PE56}.
FT   COMPBIAS   2034   2068       Polar. {ECO:0000256|MobiDB-lite:V8PE56}.
FT   COMPBIAS   2264   2279       Polar. {ECO:0000256|MobiDB-lite:V8PE56}.
FT   NON_TER       1      1       {ECO:0000313|EMBL:ETE72844.1}.
SQ   SEQUENCE   3053 AA;  345111 MW;  38C8A75D1DDC4549 CRC64;
     MADRQILLKR DYPEDRAKLC KRLAPGQKTC LHLHGIFPYL YVPYDGYGHL PDLRSLAFSI
     DRALNVTLGN PSSSVQHVFK VSLVYGMPFY GYHEKERQFM KIYLYNPAMV KRVCELLQGG
     AIMNKIYQPH EAHIPYLLQL FIDYNLYGMN LINLAAVKFR KIKKKGDAFE EIGSCRDNWT
     RSATRPHQRE DNQIPSSLIL EDIEPQSTCE LEVDAVAADI LNRLDIEDRG FVAATESERI
     FQKRLKEILK QSDFSVTSGS MDSNNESQEF SAELTLQSEI PKVVSCSPAN MIEVHSDKEL
     HREEPESKYK EDALINEEAI LNIMENSQYF QPVSQRFNNT PVFMNNSADQ AMIHLLAGLE
     DDGYEMVQQN ASSQHYSSGH YRNLQNSDDE ENEPQIEKEE MELSLLMSQQ WDSSSNDVDA
     KRRSMGRSRN QSSGEDDSSS EDDMDWNDNV LLASLSIPQL DGTADENGDN PLNNEVSRTH
     TSAIATSKTI KTTIFHKDAA ILEPPSSAKI TFQCKHTSAL SSHVLNTNDL EGLTQPSMID
     IRPDLSIHSL SNESIYNMKY PASFNNILHS EKPHQENNKS EKGPVLCEDI SVSRHLPSRK
     YTGIRKVAKD VSQHMNHQIS ENILTKKSNF VDLVYSKNKT SSEINIKANT TNLNSLFPAP
     ENCETMSCSE SNQTLILSSE KSTDRDSLNN FKLRYEEFEE HKTEKTNVNQ QAAHYMFFPS
     VVLSNCLNQP QKLGPVTYKL QHGKKQSKLK RNKKKMVLGN QQSASVTDAL STKESCYVQD
     NTSSNIPDRD ILLPNDTQVH HTVFENKIST DTRNYTDCHF EDFAQESEQT FGLCGNKYTL
     RAKRKINYET EDSESSLGIH NSKITLPHSV ENDENVDGSK KCRKRRRLSR KLPPVIIKYI
     IINRFRGRKN MLVKLGKIDS SEEQVFLTEE RMNLYKKLAP LKDFWPKVPD SPATKYPIYP
     LTPKKSNKRK AKCKSAKKRL GAKPQNIKSK TIRRTLYFRK RTHAFLSPPL PSYSAETEDC
     DLNYSDVMSK LGFLSERSAS PVNVSPPRCW SPTDPNAEEI VCNLEKETLV FKNTNRFSSK
     TVNSNVGKHI QSKTQVKKCR KQFVNATIRS NKKSNQSNKP RNNLKKKPRS KQKQKFKKVS
     TLVKIADGQN SIPSVAELKL APHPWDLPEN VHNLGNSQPF TKEIASTGCS TGHPPSAQLS
     LTANAQVNSL IYFQSLLENE KPIGHQGSSL TEDLHPGIAS LISGREKVKI NFQRSNSQSG
     IFRMEESSIQ NNVYDQCNCI SQVALKAYSS KDALKKTEEV TNSQNKLLST VGKVNENSVS
     SDVINTDQIH PGNFLRCKDN QQIVHLSEAT KHADHISSFL KTSEESHGSF QLPKKCFVAS
     LRSPVNKSEW EQKQKGFILD VSHFSPEKNT KQKVVSETIS EAQTDSQCKS KGPVTPSAFI
     EGHSGLAVLK ELLQKRQQKM QMNNIHGQAS AKSQSNIDAS FPLDSNKPAK KTCSIASSRK
     PRIPRDKKSK EKVVKLLKDT AKQLSNKTGH VTPADSSILY SDAGFESCYS LEDSLSPDHN
     YSFDINAIGQ TGFCSLYSAS QFVPADQNLP QKFLSDVAQD HYPGQAAETE FLNHNKISKE
     ENIHNSDPQS WLRSGQHSPQ LFDKRCLENN ENILHNQWKT VLPPTSQPGS PADGQQAEMC
     HEEQLQLDRN IMKKAIFLNL SSPNGDWSQN PFRKEVISEP GQLLDSVSIS FSSILSSPDG
     ELMDAASEDL ELYISRNNEG LTPTPDSSPR STSSPSQSKN GSSTARAAHI LKPLMSPPSR
     EEIMSTLLDH DLAETIYQEP FCSNPSDVPE KPREIGGRVL TVESRLPNDL LEFEGDFSLE
     GLQLWKTAFL AMAQSPRPGS PLRNSQFSTD IKQRNTHKIN DKKIVIMPCK CAPSYQQIQS
     WLQAKEDYEY LKKRAIIKSI EVEKIDESLN NMSLPKNLCH QIVKVAMNSG IPSNPAVQLE
     DLCFSSSNPT SPQTMEKFGV NISEMSKSTV KVKTTPLVTA AIDKDKKEED CTNYSSPDSP
     GLPPWQQLVS TDSKQSNLED SEGILSSLEE NKSVPEKEQK SVKKENKIPF CVSPLSKEPD
     GNSDTYFHST PIREHISQGI PEALGFTPLS GRDVQKFSSR RGKNVDALRK VLLTTQIKNQ
     FATINTQKKE TSQIEGPSLN NSYGFKISVQ NLQEAKALHE VQYLTLLSIE LHARTRRDLE
     ADPEFDPICA LFYCISSDTP LPETEKMEIT GAIVIDKDRA RSISSQGSAG STDQRTGSVG
     VTEVPPPIGG KRRSCWDSPA REHAPLLARS GISGLEVTYA TDERALFQEV VNIIKRYDPD
     ILLGYEVQMH SWGYLLQRAA ALDVDLCQMI SRVPDDKKEN RFASDLDEYG ADTMSEINIV
     GRVMLNIWRI MRHEVALTNY TFENVSFHIL HQRFPLFTSR VLSDWFDNKA DIYRWKIVDY
     YISRVRGNIQ LLEQLDLIGR TSEMARLFGI QFLHVLTRGS QYRVESMMLR IAKPMNYIAV
     TPSVQQRAQM RAPQCIPLIM EPESRFYSNA VLVLDFQSLY PSIVIAYNYC FSTCLGHIEN
     LGKNNEFKFG CSSLRVSPDL LYQLRHDITI SPSGIAFVKP SVRKGVLPRM LEEILKTRIM
     VKQSMKAYKL DKTITQMLDA RQLGLKLIAN IADSIVHKAR ETLERAIKLV NDTKKWGARV
     VYGDTDSMFV LLKGATKEQS FKIGQEIAEA VTATNPKPVK LKFEKVYLPC VLQTKKRYVG
     YMYETLDQKD PVFDAKGIET VRRDACPAVS KILERSIKLL FETRDISHIK QYVQNQCMKL
     LEGKASMQDF IFAKEYRGSS AYRPGACVPA LEITRKMLAY DRRSEPRVGE RVPYVIVYGM
     PGLPLIQLVR RPIDVLQDPN LRLNATYYIT KQILPPLARI LSLIGIDVFS WYNELPRIQK
     VSTMSRTEQE CRKGTISQYF TTLHCPVCDE LTQHGICNKC RSQPQHVIVM LNQEIRELER
     KHEQITKVCK NCTSCFDRQI PCISLNCPVF FKVSRVSREL SKAPYLRQLL DQF
//
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