ID V8PEM0_OPHHA Unreviewed; 3856 AA.
AC V8PEM0;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Dynein heavy chain 3, axonemal {ECO:0000313|EMBL:ETE72411.1};
DE Flags: Fragment;
GN Name=Dnah3 {ECO:0000313|EMBL:ETE72411.1};
GN ORFNames=L345_01759 {ECO:0000313|EMBL:ETE72411.1};
OS Ophiophagus hannah (King cobra) (Naja hannah).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE72411.1, ECO:0000313|Proteomes:UP000018936};
RN [1] {ECO:0000313|EMBL:ETE72411.1, ECO:0000313|Proteomes:UP000018936}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Blood {ECO:0000313|EMBL:ETE72411.1};
RX PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., Dirks R.P.,
RA Spaink H.P., Duboule D., McGlinn E., Kini R.M., Richardson M.K.;
RT "The king cobra genome reveals dynamic gene evolution and adaptation in the
RT snake venom system.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETE72411.1}.
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DR EMBL; AZIM01000226; ETE72411.1; -; Genomic_DNA.
DR Proteomes; UP000018936; Unassembled WGS sequence.
DR GO; GO:0005930; C:axoneme; IEA:UniProt.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd00009; AAA; 1.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF1; DYNEIN HEAVY CHAIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000018936};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..3856
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004771449"
FT DOMAIN 1184..1320
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 1816..1957
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT COILED 569..596
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2655..2703
FT /evidence="ECO:0000256|SAM:Coils"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ETE72411.1"
SQ SEQUENCE 3856 AA; 442077 MW; 6064757C193E779C CRC64;
MAPGLQLAFL LLPAWRLTMS APSKSTNSPD EDEDVWNLQL PPIALPSTSK ELTEKQKKLM
KYRRVTEQQK MLNKIIINVA TKDYTMSMEE FVNRDPEPVA PQLPYTYEVF LSSLKGLDFS
RPWHKSFIQA RKQIFENLHI LHPTLRILLE IGYITFSNLL IVDVSGFRSK GPIECESLQN
DVSIKCLKTE EKILNTWYPR VINLFTRKEA LEGVKPDQMD SFYSCVATLM SNQLKELLKR
SVEAYVKLFD LEDQRWLPLF RMELTFDDEK MDFYPSFHDL EDTILCIITL ISQTLQNVQT
IHSWLGGTNI VTTIDTELPD HVIAWASFVL KTALNENLKG AKAHFDSYEI KYGWLVDGVA
DDRIKTFIAE EHSFDEYAEL IDEFLNLSTE IMSLPMIAHF SMVRLDCDDL KQGLCEKAKS
FAYKLLDLLA SNHREENNKI CNEFETIKDR ALKVPETTEE MMESIAFIDK AKTIGIQKLY
KRIKECQRRM NYLLDVYLFE PEDLTLNATV LLWPQNINPI FDENDDIIEM SKRKGESELL
AKREKLILEV EKQIRRMHEF TEYCDLDRMQ QYVTDMRTLQ KRIQDADEAV TFINKEEKLL
NWELTEYPEL ETLKLNIEPY QKLFVFILKW QRTEKRWMDG AFLDLNGEKM EGEVDEFFRE
IYKTVRFFQQ QQKKAEIERK KSLRRAVVEE RVEEEKKDTP TISMCNAVMQ QVKDFKENIP
LVTILCNPGI KARHWNQMSE IVGYDLTPDS GSTLRKVLKQ NLTPYLEQFE VISMGASKEF
SLEKAMHNMM ETWDSIFFQT GLYRETGVSI LSAVDEIQTI LDDQIVKTQT MRGSPFIKPF
EKQMKEWEER LIRIQETIDE WLKVQAQWLY LEPIFSSEDI MQQMPEEGRQ FQTVLAATSL
TGLLEKLQNC NDLLDKIMKG LNAYLEKKRL FFPRFFFLSN DEMLEILSET KDPLRVQPHL
KKCFEGIAKL EFRPNLDIKS MYSTEGERVE FILTISTSEA RGAVEKWLIQ VEDIMLRSIH
DVITRSRLAY PESPRKDWVR EWPGQVVLCV SQMFWTSEVH EAIASGPEGL QNYYQALQYQ
LNDIVELVRG KLSKQTRITL GALVTIDVHA RDVVMEMIES GVSKETDFQW LAQLRYYWEY
DNVRVRIINC NVKYAYEYLG NSPRLVITPL TDRCYRTLIG AFYLNLGGAP EGPAGTGKTE
TTKDLAKAVA VQCVVFNCSD GLDYLAMGKG LASSGAWACF DEFNRIELEV LSVVAQQILC
IQRAIQQKLE IFNFEGTELR LNPNCFVAIT MNPGYAGRSE LPDNLKVLFR TVAMMVPNYA
LIAEISLYSY GFLNAKPLSV KIVMTYRLCS EQLSSQFHYD YGMRAVKAVL IAAGNLKLKF
PTENEDILLL RSIKDVNEPK FLSHDIPLFM GITSDLFPGI KLPEADYSDF LECANECCKE
HNVQPVKVFL EKMIQTYEMM IVRHGFMLVG EPFSGKTKVL HVLADTLSLM NERGYGEEEK
VIHRTVNPKA ITMGQLFGRF DPVSHEWTDG IVANTFREFA LTETPDRKWV VFDGPIDTLW
IESMNTVLDD NKKLCLMSGE IIQMSPQMSL IFEAMDLSQA SPATVSRCGM IYLEPSQLGW
KPLVTSWLMT LPEPLNEKEF QDLFEDLFDW LVPPALRVRR KQCKELVPTS DSNNVVSLAR
LLEILLCHKA KKDPSNKNIH KWVTGCFAFA MIWSIGATCD SDGRIIFDNF MRDIVIGKLD
EHPIPASIGK WEHPFEEKGL VYDYMFELKG KGRWAHWNEA VKSINYSDKN IKVQDIIVPT
MDTVRYTYLM ELCIKYGKAL LFVGPTGTGK SVYVKDKLMH HLQKDLYFPF FLNFSARTSA
NQTQNIIMAR LDKRRKGIYG PPVGKKCIIF VDDMNMPALE QYGAQPPVEL LRQYDLKDTN
KITLVDIQLM AAMGPPGGGR NPVTPRFLRH FNICTINSFS DETMVRIFST VVSLYLRVNE
FIPEYFTVGN QIVSGTMEVY KKAMANLLPT PAKSHYTFNL RDFSRVILGC LLIKKDSVVN
KHTMIRLFVH EVFRVFYDRL VDDADRAWLF KLIKEIVKEH FKEAFDAVFS HLRQGNAPIS
EEDLRNLLFG DYMNPDLEGE ERIYYEIPSI QMFNDVVELC LDEYNQTHKT RMNLVIFRYV
LEHLSRICRV LKQSGGNALL VGMGGSGRQS LTRLATSMAK MNIFQPEISK SYGMNEWRED
LKNLLKSAGM KGLKTVFLIT DTQIKEEGFL EDVDSVLNTG EVPNLFAADE KQEVMEGVRA
VAQAGHKHEE LGPLALFAFF VNRCKDNLHV VVAFSPIGDA FRNRLRQFPS LINCCTIDWF
QPWPEDALER VAIKFLEKLE LTENERQEVV PICKHFHTSV LSLSERFLNQ LGRHNYVTPT
SYLELIGSFQ LLLSQNRDTI MKAKKRYTNG LDKLAFAESQ VGEMKKELVD LQPKLEQAKV
DNAAMMKIIE KESAEVEAKS KTVKVDEELA TEKAAEAQAL KNECESDLAE AIPALEAALA
ALDTLKANIT IVKSMKNPPS GVKLVMAAIC VMKDIKPEKI ADPSGIGGKI LDYWGPSKKL
LGEMNFLKDL REYDKDNIPV SVMQKIRSEY LTNPEFDPPK VAKASSAAEG LCKWIMAMEV
YDRVAKVVAP KKARLAEAQQ SLAHTMALLN QKRAELKAVE DRLEALQETF TEKTEEKARL
EFQVDLCAKK LERAEKLIGG LGGEKSRWSH AADDLQNTYD NLTGDVLVSA GVIAYLGAFT
AGFRQECTKD WSKLCKVKNI PCSENFSLSK TLGDPIKIRA WNIAGLPTDQ FSIDNGVIVD
NSRRQANKWI KHSEKDNRLS VIKFTDSDYM RTLENCIQFG TPLLLENVGE EIDPSLEPLL
LRQTFKQGGM DCIRLGETII EYSFDFKFYI TTKLRNPHYL PELATKVSLL NFMITPEGLE
DQLLGIVVAK ERPELEEERN ALILQSAANK KQLKDIENKI LETLQSSEGN ILEDESAITI
LDSAKIMSNE ITKKQQIAEK TEIKIAQSRE GYRPIAKHSS VLFFSIADLA NIDPMYQYSL
SWFVNLYINS IHDSNKSKIL EKRLRYLNDH FTYNLYCNVC RSLFEKDKLL FSFLLCCNLL
IARKEIEHQE FMFLLTGGVG LKSKFKNPDP SWLQDKSWDE ICRASDMPAF KGLRNHVTSQ
PDEWRSIYDS KEPQTVPLPK PWNTDLNEIK KMIILRCLRP DKITPAITTF VTDKLGKKFV
EPPPFDLTRS YLDSNSSIPL IFVLSPGADP MASLLKFAND KNMIGNKFQS ISLGQGQGPI
ASKMIREGME EGTWVCLQNC HLAVSWMPML EKICEEFNSE TCHSLFRLWL TSYPSPKFPV
TILQNGVKMT NEPPTGLRLN LLQSFLSDPI SDADFFAGCP GKEQRWEKLL FGVCFFHALV
QERKKFGPLG WNIPYGFNES DLRISVRQLQ LFINEYEHIP FEAITYLTGE CNYGGRVTDD
WDRRLLLTML ADFYNTDIVK NSHYKFSPSG NYYAPPRGTY DDYIEFIKNL PVSQQPEVFG
LHDNVDISKD LQQTKITFES LLLTQGGSNQ GGSKSGGDST LYEIADDILN KLPKDYDIET
ALIKYPVRYE ESMNTVLVQE MERFNNLIKT IRTTLVNLKK AIKGLVVMDS ELEALCASLL
IGKVAENWAK RSYPSLKPLG SYVLDFLARL KFLQDWYDSG KPCVFWLSGF FFTQAFLTGA
MQNYARKYTI PIDLLGYEFQ VIPRDTSTTA PEDGVYINGL FLDGARWDRA KGLLGEQHPK
ILFDMMPIIW IKPAKTSEIK KSNAYVCPLY KTSERKGVLS TTGHSTNFVI AMKLLTDQPV
QHWIKRGVAL LCQLDD
//
