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Database: UniProt
Entry: V8PF24_OPHHA
LinkDB: V8PF24_OPHHA
Original site: V8PF24_OPHHA 
ID   V8PF24_OPHHA            Unreviewed;       570 AA.
AC   V8PF24;
DT   19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT   19-FEB-2014, sequence version 1.
DT   31-JUL-2019, entry version 21.
DE   SubName: Full=G protein-activated inward rectifier potassium channel 4 {ECO:0000313|EMBL:ETE72603.1};
DE   Flags: Fragment;
GN   Name=Kcnj5 {ECO:0000313|EMBL:ETE72603.1};
GN   ORFNames=L345_01557 {ECO:0000313|EMBL:ETE72603.1};
OS   Ophiophagus hannah (King cobra) (Naja hannah).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata;
OC   Toxicofera; Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX   NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE72603.1};
RN   [1] {ECO:0000313|EMBL:ETE72603.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Blood {ECO:0000313|EMBL:ETE72603.1};
RX   PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA   Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA   McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA   Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA   de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA   Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA   Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W.,
RA   Dirks R.P., Spaink H.P., Duboule D., McGlinn E., Kini R.M.,
RA   Richardson M.K.;
RT   "The king cobra genome reveals dynamic gene evolution and adaptation
RT   in the snake venom system.";
RL   Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003822};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003822}.
CC   -!- SIMILARITY: Belongs to the inward rectifier-type potassium channel
CC       (TC 1.A.2.1) family. {ECO:0000256|RuleBase:RU003822}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:ETE72603.1}.
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DR   EMBL; AZIM01000202; ETE72603.1; -; Genomic_DNA.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005242; F:inward rectifier potassium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.1400; -; 1.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR041647; IRK_C.
DR   InterPro; IPR016449; K_chnl_inward-rec_Kir.
DR   InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
DR   InterPro; IPR040445; Kir_TM.
DR   PANTHER; PTHR11767; PTHR11767; 1.
DR   Pfam; PF01007; IRK; 1.
DR   Pfam; PF17655; IRK_C; 1.
DR   PRINTS; PR01320; KIRCHANNEL.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   3: Inferred from homology;
KW   Ion channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434609, ECO:0000313|EMBL:ETE72603.1};
KW   Ion transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434639};
KW   Membrane {ECO:0000256|SAAS:SAAS00434581, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434575};
KW   Potassium transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434641};
KW   Transmembrane {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434543, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00036756,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00036755};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00048561}.
FT   TRANSMEM    227    249       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    304    327       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      193    332       IRK. {ECO:0000259|Pfam:PF01007}.
FT   DOMAIN      339    507       IRK_C. {ECO:0000259|Pfam:PF17655}.
FT   REGION       90    114       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION      534    570       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS     97    112       Polar. {ECO:0000256|SAM:MobiDB-lite}.
FT   COMPBIAS    551    570       Polyampholyte. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   NON_TER       1      1       {ECO:0000313|EMBL:ETE72603.1}.
SQ   SEQUENCE   570 AA;  65690 MW;  4677AED6D5B3C1C0 CRC64;
     MLPNCRSNIE LKLENNLYIY NDVGDEPLKY DESRIRRNSI PPAKIPTAKY MLAYLPRPPT
     DTGSHGTSSH VPNVRSVLLQ KRLSMVEQAS FSAVGPPKHQ PPSSNSTDKL PKYCWPSRTD
     PLPPSLLREF NAQFYPQHAF SVPNIINSSR SKTLTRSVIS MPTSEKGQSK LCKLIEDERQ
     FVGRNKHQRQ RYVTKVGKCK VNLGNIQEKK RFLSDIFTTI VDLKYRWFLF IFSMCYIITW
     VVFGIMYYLD AWIRDDVNHI GDTEWKACIE NIDNFISALL FSVESQRTIG YGSRIVTANC
     SEGVLLLMAQ SIIGSMIDAL MVGCMFVKIS RPKKRAQTLI FSKKCVISSR DEKLCLMFRI
     GDLRDSHMVD AKIRAKLIKS RQTKEGEFIP LDQSELNLGY GTGEDRLFLV EPQVICHIIN
     EVSPFWEMSA EALKREQFEI IIILEGIVEA TGMTCQARTS YIENEILWGQ RFEPCMTLEK
     GAFHVDYTKF ERTFEVQTPR LSAREIYDLK EMENQEQSTL NFYWDHLAQP CSSAEPNHEA
     QRGGCPNEES FSHFTEEKRN NEYRNHSTRL
//
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