ID V8PFC8_OPHHA Unreviewed; 2007 AA.
AC V8PFC8;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Myosin-X {ECO:0000313|EMBL:ETE72713.1};
DE Flags: Fragment;
GN Name=MYO10 {ECO:0000313|EMBL:ETE72713.1};
GN ORFNames=L345_01440 {ECO:0000313|EMBL:ETE72713.1};
OS Ophiophagus hannah (King cobra) (Naja hannah).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE72713.1, ECO:0000313|Proteomes:UP000018936};
RN [1] {ECO:0000313|EMBL:ETE72713.1, ECO:0000313|Proteomes:UP000018936}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Blood {ECO:0000313|EMBL:ETE72713.1};
RX PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., Dirks R.P.,
RA Spaink H.P., Duboule D., McGlinn E., Kini R.M., Richardson M.K.;
RT "The king cobra genome reveals dynamic gene evolution and adaptation in the
RT snake venom system.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cell cortex
CC {ECO:0000256|ARBA:ARBA00004544}.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|PROSITE-ProRule:PRU00782}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00782}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETE72713.1}.
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DR EMBL; AZIM01000188; ETE72713.1; -; Genomic_DNA.
DR Proteomes; UP000018936; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13202; FERM_C_MyoX; 1.
DR CDD; cd17206; FERM_F1_Myosin-X; 1.
DR CDD; cd13296; PH2_MyoX; 1.
DR CDD; cd13297; PH3_MyoX-like; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.190; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 6.20.240.20; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR Gene3D; 1.25.40.530; MyTH4 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 4.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR031971; MYO10_CC.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR041797; MyoX_FERM_C.
DR InterPro; IPR040640; MyoX_N_SH3.
DR InterPro; IPR000857; MyTH4_dom.
DR InterPro; IPR038185; MyTH4_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR46049; AGAP003327-PA; 1.
DR PANTHER; PTHR46049:SF4; UNCONVENTIONAL MYOSIN-X ISOFORM X1; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF00612; IQ; 2.
DR Pfam; PF16735; MYO10_CC; 1.
DR Pfam; PF00063; Myosin_head; 3.
DR Pfam; PF00784; MyTH4; 1.
DR Pfam; PF00169; PH; 2.
DR Pfam; PF18597; SH3_19; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00295; B41; 1.
DR SMART; SM00015; IQ; 3.
DR SMART; SM00242; MYSc; 1.
DR SMART; SM00139; MyTH4; 1.
DR SMART; SM00233; PH; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50729; PH domain-like; 5.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS50096; IQ; 2.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51016; MYTH4; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|PROSITE-ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Coiled coil {ECO:0000256|SAM:Coils};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000018936};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 45..685
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 1156..1254
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1336..1442
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1480..1640
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT DOMAIN 1645..1989
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT REGION 939..1009
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1068..1087
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 751..900
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 958..986
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 139..146
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ETE72713.1"
SQ SEQUENCE 2007 AA; 230760 MW; D5EE151A0447611C CRC64;
MRPCTVGSCA NGSMLFTSDY GEVFCYAQGS LPKEKILPMH QSSVDGVEDM SMLGDLHEAA
ILLNLHQRYK QNHIYTSIGS ILVSVNPYKP IAGLYDASAI DLYRQHCLGE LPPHIFATAS
ECYSCLWRRH DSQCILISGE SGAGKTESTK LLLKFLSAMS QFSLGSSALE KTTHVEEAIL
ESSPVLEAFG NAKTVYNNNS SRFGKFIQLH FSPHGHIQGG RVTDCILYLN GSSSDCDDPC
FFIEGLHLLE PKNYRYLNQS GCIINEDLDD QEMFSKVMTA FEVMGFSSEE IRDVFKLISG
ILQLGNIEFM TAGGAQITTK TVLHNVSELL GLDTFQLSEV LTQRSMFLRG EEISSPLTVE
QATDSRDSLA MALYSQCFSW IIGKINSKIK GKENFKSVGI LDIFGFENFQ VNRFEQFNIN
YANEKLQEYF NKHIFSLEQL EYNREGIIWE AIDWMDNAEC LDLIEKKLGL LALVNEESRF
PKGTDSTLLE KLHNQHGNNQ YYMKPRVTDF HFGIQHYAGE VGFEQSLGPF SRLGTLDLFI
DAGGLALLMA GQRLDFIYDL FERVASCNSE DTLKLGTQRR RPTVSSQFRA PNLFSPDVVL
KQLRYSGMLE TVKIRRAGFP VRRLCQDFLC RYKMLLKNWS NPDSARTTCT NFLQIYDNTQ
REWKLGKTKV FLKEVLEQKL EKAREEELKK AATVIRAHVL GYMARKKYRR VLASVVTIQK
NYRAHFWKKS LLRLKASAIV LQKHWRGCLA RNLYQDLLEE KQRQKEEAEE QRREEERIRK
EEEERQWQEE RECRRKQEEK EKKRYNGYIS EMKKEELEAA LQIAQMEVLK TQKENHPLRE
EEQRQMEEIL RLEREIEKLQ WQQKADHVSI TCENTKNEMK RQREEEIQRL EKEASRVAQE
FLELLDFGNL DESVQNLERS LSNEGTLNIE CSLVAPLAEE EEDEGFPADE EGPPVPSPSL
LNQDSSTRTS DNYYSEEDTS PNMPVSGEEE NREGNALLPS TERAGSPQKE HLKSIYWIGS
EVMQNDMVEV EDPIYSLPPD VESDYDHEEY DGIVDISSTS IEPLNREEGL RNSHSNGVDS
NRGSLDSFLD TKDEEGDTYM DTDEEFCSGR VTLFNGSGPA YFHSYLYMKG GLMNPWRRRW
CVLKNEAFMW FRAKQEALKS GWLYKKGGGM STLSRRNWKR RWFVLREAKL MYFENDSEEK
LKGTIDIRKA KEIVDIHEKE NALDIVTGDR VYHIVAESPE DASDWFNVLS HVHSATEQQL
REMQDEQANP KNAVGTLDVG LIDSVCASDN PDRPNSFVII TANRVIHCNS DIPEEMHHWI
SLLQKPKGES RVDGQEFIVR GWLHKEVQSN SKTLSLKLKK RWFVLTSTAL DYYKSSERTA
TKLGTLVLNS LCSVVQPDER IFKETAGYWN ITVHGRKHSY HLYTKLLNEA MRWASAIQGV
IDSKVPIETP TQQLIRDIRE NNTNSEVVEQ IYRRNPILRY TQHPLHSPLL PLPYGDVGIN
MQQEKGYSSL QDEAMKIFNS LQEIESVSDP IPIIQGILQT CHDLRGLRDE VYCQLIKQTN
HVPQPNSPGN LHHWQLMTCM SCTFLPSRGI LRYLKFHLRR VKDLFLGTEV DQYSQFITDS
LKKTKSREFV PSQEEIQALI AREEMTTTVY CHGGGSCQIT INSHTSAGEV VEKLIRGLAM
EDSRNMFALF ERNKHVDKAI ESRVIVADVL AKFERLAGSM EEDVDGHWQL YFKLYCFLDV
ENVPKEGVEF AFMFEQAHES LIDGHFPGPE ETLQHLASLR LQYLYGDYFK VSWSLDSIYP
VNRLKSKILQ SMKSSGSSSQ VLERRRTSFL EGTLKRGFKT GSVKKQKVEE EQMVEMWVKE
ELSAARASIA EKWNKLQGLL QQQAMVAYMA IMKEWSGYGS TLFDVECKEG GFPNDLWLSV
NTENVSLYKR GEPKPLETFQ YEQIIFFGAP QPNTFKLTVD EREMYFETPQ VGEIIKIMKA
YINMIVKKCC SIRSATSLDS HSSIWMR
//
