ID V8PG16_OPHHA Unreviewed; 560 AA.
AC V8PG16;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 03-MAY-2023, entry version 31.
DE SubName: Full=FERM domain-containing protein 6 {ECO:0000313|EMBL:ETE72837.1};
DE Flags: Fragment;
GN Name=FRMD6 {ECO:0000313|EMBL:ETE72837.1};
GN ORFNames=L345_01328 {ECO:0000313|EMBL:ETE72837.1};
OS Ophiophagus hannah (King cobra) (Naja hannah).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE72837.1, ECO:0000313|Proteomes:UP000018936};
RN [1] {ECO:0000313|EMBL:ETE72837.1, ECO:0000313|Proteomes:UP000018936}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Blood {ECO:0000313|EMBL:ETE72837.1};
RX PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., Dirks R.P.,
RA Spaink H.P., Duboule D., McGlinn E., Kini R.M., Richardson M.K.;
RT "The king cobra genome reveals dynamic gene evolution and adaptation in the
RT snake venom system.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETE72837.1}.
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DR EMBL; AZIM01000173; ETE72837.1; -; Genomic_DNA.
DR AlphaFoldDB; V8PG16; -.
DR Proteomes; UP000018936; Unassembled WGS sequence.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13185; FERM_C_FRMD1_FRMD6; 1.
DR CDD; cd17198; FERM_F1_FRMD6; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR041781; FRMD6-FERM_C.
DR InterPro; IPR047145; FRMD6-like.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR13429; FERM DOMAIN (PROTEIN4.1-EZRIN-RADIXIN-MOESIN) FAMILY; 1.
DR PANTHER; PTHR13429:SF11; FERM DOMAIN-CONTAINING PROTEIN 6; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR SMART; SM00295; B41; 1.
DR SMART; SM01196; FERM_C; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50057; FERM_3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000018936}.
FT DOMAIN 5..309
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT REGION 344..387
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 405..453
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 418..436
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 437..453
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ETE72837.1"
SQ SEQUENCE 560 AA; 64569 MW; 7C7CCDE3CFAD583A CRC64;
MQDRRSVCIF LPNDDSLNII INVKILCHEL LVQVCDLLRL KDGHLFGLSV IQNNEHIYME
LSQKLYKYCP KEWKKEASKG IDQFGPPMII HFRVQYYVEN GRLISDRTAR YYYYWHLRKQ
VLRSQCMLRE EAYFLLAAFA LQADLGNFKR NKHFGKYFEP EAYFPAWVVA KRGKDYILKH
IPIMHKDQCA LTASEAHLKY IKEAVRLDDV AVHYYRLYKD KKEIDASLSL GLTTKGIQIF
QNVNSERQLL YDFPWTNVGK LVFVGKRFEI LPDGLPSARK LTYYTGCPLR SRHLLQLLSN
SHRLYMNLQP LLRQIRKLEE NEEKKQYRES YISDALDLDM DQLEKRSRAS GSSSGSVKHK
RLSRHSTASH SSSHTSGIET DPKPRERGTE EDFMVAAVHR QLRACSSMTS HGSSHTSGVE
SSEKERLEED SSQEDGLVVK EVNSSTSSSS ETVVKLRGQS IDSLPQSICQ KPRTSTDRHS
LSLDDIRLYQ KDFLRLASLC QETAQSYTFG CGHELAEDSL YCNGCLAQQC INIQNAFPVK
RTSKYFSLDL THEDVPEFVV
//
