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Database: UniProt
Entry: V8PHJ9_OPHHA
LinkDB: V8PHJ9_OPHHA
Original site: V8PHJ9_OPHHA 
ID   V8PHJ9_OPHHA            Unreviewed;       463 AA.
AC   V8PHJ9;
DT   19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT   19-FEB-2014, sequence version 1.
DT   31-JUL-2019, entry version 27.
DE   SubName: Full=G protein-activated inward rectifier potassium channel 2 {ECO:0000313|EMBL:ETE73446.1};
DE   Flags: Fragment;
GN   Name=KCNJ6 {ECO:0000313|EMBL:ETE73446.1};
GN   ORFNames=L345_00713 {ECO:0000313|EMBL:ETE73446.1};
OS   Ophiophagus hannah (King cobra) (Naja hannah).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata;
OC   Toxicofera; Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX   NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE73446.1};
RN   [1] {ECO:0000313|EMBL:ETE73446.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Blood {ECO:0000313|EMBL:ETE73446.1};
RX   PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA   Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA   McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA   Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA   de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA   Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA   Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W.,
RA   Dirks R.P., Spaink H.P., Duboule D., McGlinn E., Kini R.M.,
RA   Richardson M.K.;
RT   "The king cobra genome reveals dynamic gene evolution and adaptation
RT   in the snake venom system.";
RL   Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003822};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003822}.
CC   -!- SIMILARITY: Belongs to the inward rectifier-type potassium channel
CC       (TC 1.A.2.1) family. {ECO:0000256|RuleBase:RU003822}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:ETE73446.1}.
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DR   EMBL; AZIM01000090; ETE73446.1; -; Genomic_DNA.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015467; F:G-protein activated inward rectifier potassium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.1400; -; 1.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR041647; IRK_C.
DR   InterPro; IPR016449; K_chnl_inward-rec_Kir.
DR   InterPro; IPR003275; K_chnl_inward-rec_Kir3.2.
DR   InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
DR   InterPro; IPR040445; Kir_TM.
DR   PANTHER; PTHR11767; PTHR11767; 1.
DR   PANTHER; PTHR11767:SF19; PTHR11767:SF19; 1.
DR   Pfam; PF01007; IRK; 1.
DR   Pfam; PF17655; IRK_C; 1.
DR   PIRSF; PIRSF005465; GIRK_kir; 1.
DR   PRINTS; PR01328; KIR32CHANNEL.
DR   PRINTS; PR01320; KIRCHANNEL.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   3: Inferred from homology;
KW   Ion channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434609, ECO:0000313|EMBL:ETE73446.1};
KW   Ion transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434639};
KW   Membrane {ECO:0000256|SAAS:SAAS00434581, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434575};
KW   Potassium transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434641};
KW   Transmembrane {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434543, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00036756,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00036755};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00048561}.
FT   TRANSMEM    133    157       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    207    231       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       97    236       IRK. {ECO:0000259|Pfam:PF01007}.
FT   DOMAIN      243    413       IRK_C. {ECO:0000259|Pfam:PF17655}.
FT   REGION        9     28       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION       60     81       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION      432    463       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS    433    463       Polyampholyte. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   SITE        222    222       Role in the control of polyamine-mediated
FT                                channel gating and in the blocking by
FT                                intracellular magnesium.
FT                                {ECO:0000256|PIRSR:PIRSR005465-1}.
FT   NON_TER       1      1       {ECO:0000313|EMBL:ETE73446.1}.
SQ   SEQUENCE   463 AA;  52487 MW;  CCC5A02EEAD6A216 CRC64;
     MSLIAFQVMK HSASRQRSPP ATPVAHGEKA AEATQHNIAA LFHSLEGEAN VLEGDSMEQD
     VESPVTIHPP KLPKQAREDL PKHLSKEGAK RKIQRYVRKD GKCNVHHGNV RETYRYLTDI
     FTTLVDLKWR FNLLIFVLVY TVTWLFFGFI WWLIAYIRGD MEHIGDKKWT PCVSNLNGFV
     SAFLFSIETE TTIGYGYRVI TDKCPEGIIL LLVQSVLGSI VNAFMVGCMF VKISQPKKRA
     ETLVFSTNAV ISMRDGKLCL MFRVGDLRNS HIVEASIRAK LIKSKQTKEG EFIPLNQTDI
     NVGYYTGDDR LFLVSPLIIS HEINQQSPFW EISKTQLSKE ELEIVVILEG MVEATGMTCQ
     ARSSYITSEI LWGYRFTPVL TLEDGFYEVD YNNFHETYET NTPSYSAKEL AEMASRAELP
     LTWSVSSQLD QHAELEAGEE AKSHEEQAER NGDVANLENE SKV
//
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