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Database: UniProt
Entry: V8PHR1_OPHHA
LinkDB: V8PHR1_OPHHA
Original site: V8PHR1_OPHHA 
ID   V8PHR1_OPHHA            Unreviewed;       349 AA.
AC   V8PHR1;
DT   19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT   19-FEB-2014, sequence version 1.
DT   03-MAY-2023, entry version 31.
DE   SubName: Full=Izumo sperm-egg fusion protein 1 {ECO:0000313|EMBL:ETE73432.1};
DE   Flags: Fragment;
GN   Name=Izumo1 {ECO:0000313|EMBL:ETE73432.1};
GN   ORFNames=L345_00727 {ECO:0000313|EMBL:ETE73432.1};
OS   Ophiophagus hannah (King cobra) (Naja hannah).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX   NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE73432.1, ECO:0000313|Proteomes:UP000018936};
RN   [1] {ECO:0000313|EMBL:ETE73432.1, ECO:0000313|Proteomes:UP000018936}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Blood {ECO:0000313|EMBL:ETE73432.1};
RX   PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA   Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA   McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA   Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA   de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA   Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA   Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., Dirks R.P.,
RA   Spaink H.P., Duboule D., McGlinn E., Kini R.M., Richardson M.K.;
RT   "The king cobra genome reveals dynamic gene evolution and adaptation in the
RT   snake venom system.";
RL   Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC   -!- SIMILARITY: Belongs to the Izumo family.
CC       {ECO:0000256|ARBA:ARBA00009633}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ETE73432.1}.
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DR   EMBL; AZIM01000092; ETE73432.1; -; Genomic_DNA.
DR   AlphaFoldDB; V8PHR1; -.
DR   Proteomes; UP000018936; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR   GO; GO:0007342; P:fusion of sperm to egg plasma membrane involved in single fertilization; IEA:InterPro.
DR   GO; GO:0035036; P:sperm-egg recognition; IEA:InterPro.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR029389; IZUMO.
DR   InterPro; IPR032699; Izumo-Ig.
DR   InterPro; IPR032700; IZUMO1.
DR   PANTHER; PTHR35540; IZUMO SPERM-EGG FUSION PROTEIN 1; 1.
DR   PANTHER; PTHR35540:SF1; IZUMO SPERM-EGG FUSION PROTEIN 1; 1.
DR   Pfam; PF15005; IZUMO; 1.
DR   Pfam; PF16706; Izumo-Ig; 1.
DR   SUPFAM; SSF48726; Immunoglobulin; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018936};
KW   Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           19..349
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004771573"
FT   TRANSMEM        298..322
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          126..239
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   REGION          327..349
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        331..349
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:ETE73432.1"
SQ   SEQUENCE   349 AA;  40104 MW;  648D1C1DE9F42E81 CRC64;
     MSWLEFGLLT MVITGSQGCL QCSKEAIALQ EEFKNSYLEN KLRRNPELKR KLQQLLDNIM
     EGLSQQPIHP QKYMAFIDEL TLKKLTVYFK RSLNQIKENN FEGEQLFNEL MWSLQKLVTY
     FQEVMPQVTK RRMFYTFISC SSCIANQQTC TKNFHCGERK VHVEIDEDLI LDCALKWHKA
     SHGVKTYRFY RMVNNKEKLM ASGADSFLTK KEVNMKDAGR YRCKMVDTKG YTSSQLDFQV
     VVLPPKEKTT WFTHPPALVP QPSSLSPPSS LLSLPPVSMK NPLILGISSR APPPEADWTA
     WKVSGITGGV LSFIVVAFLC YYRHMAKKEE EEEDDDDESD SESDSESES
//
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