ID   V8PHS5_OPHHA            Unreviewed;       833 AA.
AC   V8PHS5;
DT   19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT   19-FEB-2014, sequence version 1.
DT   24-JAN-2024, entry version 30.
DE   SubName: Full=Biotin--protein ligase {ECO:0000313|EMBL:ETE73447.1};
DE   Flags: Fragment;
GN   Name=HLCS {ECO:0000313|EMBL:ETE73447.1};
GN   ORFNames=L345_00714 {ECO:0000313|EMBL:ETE73447.1};
OS   Ophiophagus hannah (King cobra) (Naja hannah).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX   NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE73447.1, ECO:0000313|Proteomes:UP000018936};
RN   [1] {ECO:0000313|EMBL:ETE73447.1, ECO:0000313|Proteomes:UP000018936}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Blood {ECO:0000313|EMBL:ETE73447.1};
RX   PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA   Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA   McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA   Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA   de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA   Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA   Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., Dirks R.P.,
RA   Spaink H.P., Duboule D., McGlinn E., Kini R.M., Richardson M.K.;
RT   "The king cobra genome reveals dynamic gene evolution and adaptation in the
RT   snake venom system.";
RL   Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC   -!- SIMILARITY: Belongs to the biotin--protein ligase family.
CC       {ECO:0000256|ARBA:ARBA00009934}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ETE73447.1}.
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DR   EMBL; AZIM01000090; ETE73447.1; -; Genomic_DNA.
DR   AlphaFoldDB; V8PHS5; -.
DR   Proteomes; UP000018936; Unassembled WGS sequence.
DR   GO; GO:0004077; F:biotin-[acetyl-CoA-carboxylase] ligase activity; IEA:InterPro.
DR   GO; GO:0036211; P:protein modification process; IEA:InterPro.
DR   CDD; cd16442; BPL; 1.
DR   InterPro; IPR045864; aa-tRNA-synth_II/BPL/LPL.
DR   InterPro; IPR004408; Biotin_CoA_COase_ligase.
DR   InterPro; IPR003142; BPL_C.
DR   InterPro; IPR004143; BPL_LPL_catalytic.
DR   NCBIfam; TIGR00121; birA_ligase; 1.
DR   PANTHER; PTHR12835; BIOTIN PROTEIN LIGASE; 1.
DR   PANTHER; PTHR12835:SF5; BIOTIN--PROTEIN LIGASE; 1.
DR   Pfam; PF02237; BPL_C; 1.
DR   Pfam; PF03099; BPL_LplA_LipB; 1.
DR   SUPFAM; SSF55681; Class II aaRS and biotin synthetases; 1.
DR   PROSITE; PS51733; BPL_LPL_CATALYTIC; 1.
PE   3: Inferred from homology;
KW   Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:ETE73447.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018936}.
FT   DOMAIN          562..760
FT                   /note="BPL/LPL catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS51733"
FT   REGION          137..156
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:ETE73447.1"
SQ   SEQUENCE   833 AA;  93290 MW;  0D04719D24F6DD5F CRC64;
     MDVPSLDDLN KWTLFIVSQF SYLEQVVEDE HITFVTEGIF IQTSSSQAVT CSAKKIVKWS
     DFCSPLAFKT GKPYILFAEA SIDNFSSLGI AFLEDRLQMD NGMVPQKIVC KYTRFSIPNK
     TVNLKKSALK ELKVVPGTKE EEKTGQTQTS ELSQDSLFEN TDKSHLETAD CAGSDDQKMH
     QEKCRLQKTN GYHEELEQLS EKEGDASEHH HLHLSSCHEC LELENSTIES VKFASAENIP
     DLPDDYSGSV EEVSGDLITG TMRRVNLTGK PPNILIYLGS DSKKVKFEEI KSVIMDCVDI
     NAYTIYQLLE KQVLTVPWVD NALLLIIAES EPISDAVSKQ FLAFMSKGGK ILGLSSTFTF
     GGVKIKSRNE IMNTIQTLVF SKDKNNEIKL NALASGKIFE VDISEKLNPM KTLGYFDSPD
     KDMMIVHLSY GSNGGEAILS QAHLEVNIRS LCRPKDDFNL LKISNIRRYD VLVEILKLLG
     LSCELSTIPS LTPLYLLSSD KVLHNTFLEW LRRNMITEGL ITSSKVSLKF VSSCTENMEI
     TPLLIPVVTD MEAFSSENFS FERYKQNLDT RILGKIVLFS EVTSTTMNLL DGLMYKMPQE
     MGLIAIAVQQ LQGKGRGGNT WLSPVGTALS TLLVIIPLTS KLGQRIPFIQ HLVSLAIVEA
     VRSIPGYQEI DLRLKWPNDI YYSDLMKLGG VLVNSTLTGD MFHILIGFGF NVNNSNPTVC
     INDLITEYNK TMNTTLEPLN ADCLIARSVT ILENLINIFQ EKGPNGILPM YYKYWVHSGK
     QVRLRNDEGP LVWIVGLDDS GFLQVYEEGK DVITVHPDGN SFDMLRNLII PKQ
//