ID V9E8G7_PHYPR Unreviewed; 1003 AA.
AC V9E8G7;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN ORFNames=F443_18954 {ECO:0000313|EMBL:ETI34567.1};
OS Phytophthora parasitica P1569.
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=1317065 {ECO:0000313|EMBL:ETI34567.1, ECO:0000313|Proteomes:UP000018721};
RN [1] {ECO:0000313|EMBL:ETI34567.1, ECO:0000313|Proteomes:UP000018721}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=P1569 {ECO:0000313|EMBL:ETI34567.1,
RC ECO:0000313|Proteomes:UP000018721};
RG The Broad Institute Genomics Platform;
RA Russ C., Tyler B., Panabieres F., Shan W., Tripathy S., Grunwald N.,
RA Machado M., Johnson C.S., Arredondo F., Hong C., Coffey M., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Phytophthora parasitica P1569.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETI34567.1}.
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DR EMBL; ANIZ01003313; ETI34567.1; -; Genomic_DNA.
DR AlphaFoldDB; V9E8G7; -.
DR EnsemblProtists; ETI34567; ETI34567; F443_18954.
DR OrthoDB; 65703at2759; -.
DR Proteomes; UP000018721; Unassembled WGS sequence.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 3.
DR Gene3D; 3.30.70.1390; ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR032171; COR.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR020859; ROC_dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR24189; MYOTROPHIN; 1.
DR PANTHER; PTHR24189:SF50; MYOTROPHIN-RELATED; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF13606; Ank_3; 1.
DR Pfam; PF16095; COR; 1.
DR Pfam; PF08477; Roc; 1.
DR SMART; SM00248; ANK; 5.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 4.
DR PROSITE; PS50088; ANK_REPEAT; 4.
DR PROSITE; PS51424; ROC; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000018721};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022777}.
FT REPEAT 92..119
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 136..168
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 169..201
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 202..234
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 329..552
FT /note="Roc"
FT /evidence="ECO:0000259|PROSITE:PS51424"
SQ SEQUENCE 1003 AA; 114130 MW; 378775F0250F203C CRC64;
MDTNEMKAPL QAVIDRLVEE REHVLGEERI TLASHLILGG IQDVLKCLER ERISSDTEES
LKRVWDKSDQ EAAAAIITLL HQGVDAKSPD GGAAIALQYA LRNSRADVIS LLLERGADVM
SLLLERGADL AARYEDDETI LHYAVRNGDV DVISLLLEKG ADVAATDNNG EIALHYAASF
GHTERILLLL DRGSDVNASD NDQLTVLHHA VTRCSPEAVL LLLNKGADAN ALTKDGLNPL
SHMILVKEDD PDDDYLGVVR LLCSQEPKLK LPPSTQSLAI NQLGMLACAQ YWQDRYEKKQ
PLLEIPSEVV KGGENAVEMY LAELEKTDSS EVVHRQKICV VGRTKWGKTS LVRSITEETS
VLVPLEDRTI GIEVFPLRFT VDGDGNKMKA THHDVTFWDF AGQGVYRVAH AVFFSKRTLY
LVCVDLAAYN EILEQAKKES KTQRDEVPQR FFEKHILRWI VLILLRQPEA EFKLIGTKHD
EVSDSSRSEI SHDIRDRLGQ FLEKLDGSIQ ITGHAATALK KEFEEGLVTT SVTNVESIQK
VKNSIKHTIT AKPHLSFKMP ITYTRVINYI LEKRQSVVGA TNQDRMDKMI VSVRQLCKDL
LKLPDFPQDT DCREILRVLH ELGDVLWYKG IDEELEKWII LDPSVVLDLV REVINHKYKE
EVDEQYKVLS QNGILPHSLL MTFPSWKSLA AVEDKMVHLF KQLLHRLNLV YPVNDMEAID
KADILVPMYW KTRETPKADL KLLATQKTIL TQDFGDSWHV ATWRYWLPIV VSDAIFVNFV
VKCYRPFVHR SARRAYFESS VRREFRAVVN HSANKTGQYN DILIEVAAPT EKLAWAEMMY
FVTDMEKILE KDYPGLTKHA RVKRFIVDDG EDRGVNDLME NPEDGKRQRA KARWLPPDFS
WFTQCAWKNG GVYEIHQLRH QLEAVKNIVV TSESCRLPRL WTLLYPRKGS HVELRIHSDV
SDVSVLYFCP VSSLCSHPQC RGCCRRESSF RSVEIGIKPK DHG
//
