ID V9EB15_PHYPR Unreviewed; 2653 AA.
AC V9EB15;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=Serine/threonine-protein kinase TOR {ECO:0000256|RuleBase:RU364109};
DE EC=2.7.11.1 {ECO:0000256|RuleBase:RU364109};
GN ORFNames=F443_17556 {ECO:0000313|EMBL:ETI36280.1};
OS Phytophthora parasitica P1569.
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=1317065 {ECO:0000313|EMBL:ETI36280.1, ECO:0000313|Proteomes:UP000018721};
RN [1] {ECO:0000313|EMBL:ETI36280.1, ECO:0000313|Proteomes:UP000018721}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=P1569 {ECO:0000313|EMBL:ETI36280.1,
RC ECO:0000313|Proteomes:UP000018721};
RG The Broad Institute Genomics Platform;
RA Russ C., Tyler B., Panabieres F., Shan W., Tripathy S., Grunwald N.,
RA Machado M., Johnson C.S., Arredondo F., Hong C., Coffey M., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Phytophthora parasitica P1569.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775,
CC ECO:0000256|RuleBase:RU364109};
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family.
CC {ECO:0000256|ARBA:ARBA00011031, ECO:0000256|RuleBase:RU364109}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETI36280.1}.
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DR EMBL; ANIZ01003046; ETI36280.1; -; Genomic_DNA.
DR EnsemblProtists; ETI36280; ETI36280; F443_17556.
DR eggNOG; KOG0891; Eukaryota.
DR HOGENOM; CLU_000178_7_1_1; -.
DR OrthoDB; 8448at2759; -.
DR Proteomes; UP000018721; Unassembled WGS sequence.
DR GO; GO:0032991; C:protein-containing complex; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0106310; F:protein serine kinase activity; IEA:RHEA.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0044877; F:protein-containing complex binding; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProt.
DR CDD; cd05169; PIKKc_TOR; 1.
DR Gene3D; 1.20.120.150; FKBP12-rapamycin binding domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 3.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR009076; FRB_dom.
DR InterPro; IPR036738; FRB_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR024585; mTOR_dom.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR026683; TOR_cat.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF9; SERINE_THREONINE-PROTEIN KINASE MTOR; 1.
DR Pfam; PF11865; DUF3385; 2.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF08771; FRB_dom; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR SMART; SM01346; DUF3385; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SMART; SM01345; Rapamycin_bind; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR SUPFAM; SSF47212; FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP); 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU364109};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|RuleBase:RU364109};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU364109};
KW Reference proteome {ECO:0000313|Proteomes:UP000018721};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Serine/threonine-protein kinase {ECO:0000256|RuleBase:RU364109};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU364109}.
FT DOMAIN 1391..2019
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 2197..2510
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 2621..2653
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT REGION 2479..2560
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2479..2493
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2653 AA; 296981 MW; 357EE26C28A0C280 CRC64;
MAESFTRFLP GLRSSNSSVR HRAAQSLRLY IESESRDLSH GLYMKWVTDI SARLMLLCNS
NENADRMGGI AAMDELVELF IAERNDQTII EFAHSLTKVF EKIPSADPPM LRVAAKALGH
IVSTGGTSLI EFVEDYHVKP ALEWLKNETF HVRRHAAVMI LKELSINAPS TSFRYMDKYF
DFIWSAFWDS KLVVRVSASE SLQSCFMLIQ QRESNRKTSW YNRALDEAEG AFKRNSSDAT
HGALLILNEL LRNTGDFMHS HYGRACRLVF SHQDHKSATV RSAVISLFPR LAKFNTSVFV
EKCYRPCMNH LLEVLFSATT TTRPDALLSI GKLSLAIGPL LARDEQALMA IMNGIKGGLQ
VRKKDFDTHR EALACLRMLA ETVGPALIRV DLESMVGPLF QNDLDSSLVE TLTTIVKKIP
PMKPIVQQKL FERLSSILRS RHNDVTGSAS TPTSRRLKTT SISVTGGMLS NLFLSATGAK
TNGTAENGAP SAEVSSAIAM QALALETLAN FDFQGNRLIP IMSFVHETVV KFLDHEVATI
RKSAALTCCK LLLPSGEDRG GNMAMTSEDF ARPVTSVLER LLTVGIADNE ASIRLRVLAS
LDSRFDPLLA LNDNLRCLFI ALNDEVFSIR QTAMSTLGRL THHNPSTVLP SLRQTLVQLL
AELEFSGDSR GKEEGALLIG CLLRSASQLA QPYVLPILRV LMKNLREDSE RRSHSRSTVS
VSKAILATLG DLAEVGAQEL TPYLGQLLPD VIDEMRDSSN PQILQVAIKT LGQLVSSTGY
VVLPYHEYPE LLDLLCQALQ KSGDAFESLR IEAGRTLGVL GALDPYNLRL FHLQKQGKLT
DAKKKEFRSS AFAVGAGGVF SLMASAANPS QAYAGPNAAK ETNGAVIGIR IGNGIGGPGV
LDGSSEEDVQ QLGESLLLTP ARKVAKSDKQ TSGKLTNIIL EVPPDDLLPS MIPDSSQYFP
TVAINALIRI LLEPRNSVHY QGTFMAIMYI CKSQRKRMGQ HLDKIIPAFL YALEKVNRSL
RKFLFEQLCD LVQIVEEQIQ PHLDHVALLS IVNSYWDEHL EEVLNLVKKL ANSLGEKFRV
YLPDLIPQML RVIRTERDNP ARPRTLLVLK TAVSLGRLLD GYLHLIIPAL VALIQSDADV
NARKQGLGSL GSLVKKLNVS VYASKIIHML ARVISSQPEM VYLAMDCLCC MVYTMGDDYA
IFVPVISQVL GRHTSRSNDI FDRYDLLVSK ILKYQPLPVA SWATDPLKAR ADTANDHKDS
NSAAQDETKS LPCDQKNLMK AWEASQRSTK EDWNEWILAF SVELLRESPS PVLRACKELA
SVYQPLAREL FNASFVSVWP HLSSTTQDNL IRSLESAFQS PHLPSEILQT LLNLAEFMEH
DDQPLPIDIR LLGSLADKCH SFAKALHYKE LEFNTNPSTD GIQALISINS KLNQPEAARG
ILKYALEKLP GIEVKASWHE KLLRWDDALA THDRVLLENP NNVEAIFGKM RCLWAIGEWR
KLNDHVQETW SKIYGEGQDL NGEQEDGEKL LDVPPALKRE LCSSGARVAF SLQNWDSIPK
YINSDMDPTE SHLFKAVVSI RRMELDEAMN SIGDCRKEMD PTLRSLVSES YARAYLPAIV
NLQMLTELEE IVSYLKAFAY KNNGELTLLS TPASSTSMST TASRRKQSIS SLNFVSSSSS
TSYGHEKQVA LKKLQTIWTR RMLGVERNIQ VWQNLMLVRS LVFDPREDVD IWLKYARLCL
KSGHINLASS ALWRVGAQPF IRSVERDPYA PIPINLGGNA GASQGFANGL LSLADSAAQD
PRVAFSYLRH LWAENREDVA LKQMDYFIEA LEQHGDPTNE DLRKLRVQVY IQLGEWQMSL
TEPHKQSYDH VLECLETATK LDPTNDRAWH EWALMNFRAL EATVKESGHG DPKRYAVRAI
QGFFRSISFG HTSYDVTKDV LRLLTLWFTQ GNRSDVHMAM VEGFQEASVD TWLDVIPQLI
ARIDTPNPKT SELLHDLLSR IGQAHPQALI YPITVASKAL NPTRKHAAEG ILAAVRRHSS
QLVYEADMVS RELIRVAILW NELWHGALEE ASKHFFNNRD VTAMIAELAP LHEQMDRIGT
EETPTLREVA FYQAFARDLA YAKEWTNVYE RTKSLDDLNQ AWDIYYSVFS KIRKQLANLS
TLELANVGPK LLSVHNLTLA VPGTYKAGAP IVRIQSFDTK VTVLTSKQRP RKVTINGSDG
KAYPFLLKGH EDLRQDERVM QLFGVINTLL ANDSDTSKRN LAIERYSVLP LSHTSGLIGW
VPNCDTLHQL IRDYREARKI QLNVEHRLMV QMAPDYDKLP LMQKVEAFKY ALGETTGQDL
YRVLWLKSQD SEVWLDRRRN FTRSLAVMSM AGYILGLGDR HPSNLMLDRV SGKLVHIDFG
DCFEVAMERD KYPEKIPFRL TRMLTQAMEV SGIEGNFRYT CEASMRVLRD NRDSLMAVLE
AFVYDPLINW RLLKKDAVPS HAQPEEDDGA AAGRGDGPDA SVDRNSVRED EGDADGEGDV
ANGGNADEDK LTEGSMKSST SSAPVTPRRR RHSSSEAAML GYNMDMLDPT MARNSMSETQ
RDNFGTSFVA AEHPQLNEKA LSVIDRVKKK LAGRDFDDGS RVLTVDAQVD RLIHQATSHE
NLCQLYYGWC PFW
//
