ID V9FHK4_PHYPR Unreviewed; 591 AA.
AC V9FHK4;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=methylenetetrahydrofolate reductase (NADH) {ECO:0000256|ARBA:ARBA00034529};
DE EC=1.5.1.54 {ECO:0000256|ARBA:ARBA00034529};
GN ORFNames=F443_06442 {ECO:0000313|EMBL:ETI49877.1};
OS Phytophthora parasitica P1569.
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=1317065 {ECO:0000313|EMBL:ETI49877.1, ECO:0000313|Proteomes:UP000018721};
RN [1] {ECO:0000313|EMBL:ETI49877.1, ECO:0000313|Proteomes:UP000018721}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=P1569 {ECO:0000313|EMBL:ETI49877.1,
RC ECO:0000313|Proteomes:UP000018721};
RG The Broad Institute Genomics Platform;
RA Russ C., Tyler B., Panabieres F., Shan W., Tripathy S., Grunwald N.,
RA Machado M., Johnson C.S., Arredondo F., Hong C., Coffey M., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Phytophthora parasitica P1569.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de novo
CC pathway. {ECO:0000256|ARBA:ARBA00034478}.
CC -!- PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion.
CC {ECO:0000256|ARBA:ARBA00004777}.
CC -!- SIMILARITY: Belongs to the methylenetetrahydrofolate reductase family.
CC {ECO:0000256|ARBA:ARBA00006743}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETI49877.1}.
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DR EMBL; ANIZ01001088; ETI49877.1; -; Genomic_DNA.
DR AlphaFoldDB; V9FHK4; -.
DR EnsemblProtists; ETI49877; ETI49877; F443_06442.
DR eggNOG; KOG0564; Eukaryota.
DR HOGENOM; CLU_025841_2_1_1; -.
DR OrthoDB; 1381745at2759; -.
DR UniPathway; UPA00193; -.
DR Proteomes; UP000018721; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:InterPro.
DR GO; GO:0004489; F:methylenetetrahydrofolate reductase (NAD(P)H) activity; IEA:UniProtKB-EC.
DR GO; GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0035999; P:tetrahydrofolate interconversion; IEA:UniProtKB-UniPathway.
DR CDD; cd00537; MTHFR; 1.
DR Gene3D; 3.20.20.220; -; 1.
DR InterPro; IPR029041; FAD-linked_oxidoreductase-like.
DR InterPro; IPR004621; Fadh2_euk.
DR InterPro; IPR003171; Mehydrof_redctse-like.
DR InterPro; IPR004620; MTHF_reductase_bac.
DR NCBIfam; TIGR00676; fadh2; 1.
DR NCBIfam; TIGR00677; fadh2_euk; 1.
DR PANTHER; PTHR45754; METHYLENETETRAHYDROFOLATE REDUCTASE; 1.
DR PANTHER; PTHR45754:SF3; METHYLENETETRAHYDROFOLATE REDUCTASE; 1.
DR Pfam; PF02219; MTHFR; 1.
DR SUPFAM; SSF51730; FAD-linked oxidoreductase; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022605};
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Methionine biosynthesis {ECO:0000256|ARBA:ARBA00023167};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000018721}.
SQ SEQUENCE 591 AA; 65877 MW; 84B348B2747356C8 CRC64;
MKVIDKINAS VERQEVFYSF EFFPPKTPAG VDNLYARMDR MAALEPLFCD MTWGAGGSSA
QLTLELSANA QKLSGLEMLM HMTCTNMAEA DIKKALDEAK DAGIQNILAL RGDPVRGASS
FDECDRGFSH AVDLVRYIRE KYGNHFCIGV AGYPEGHVEI KDKKADIQYL KEKVDAGADF
VITQLFYDVQ VFVDFVKECR AVGITVPIIP GIMPIQNYGG FERMTSFCNT FVPDEVRKAL
EPIKDNDEAV KDYGVQLGIT MSQQLIDAGV PGLHFYTLNL ERSVRRILEG LSSLSSRVPR
RELPWQTSTL SKRASESVRP IYWSNRPKSY VHRTAMWDEY PNGRWGNSES PAFGELTESH
FAPSNTSTPR ERRAMWGEAP AAKEDVRRTF VQYVRGEISS LPWCDAALHA ETSTVQQELA
AANSAGFLTI NSQPRVNGAL SDDPMFGWGG PGGRVYQKAY VECFVSPENM KIIIENAAKK
PSIQYHAVNL NGHSYSNASK SAVAVTWGVF PNKEILQPTI VDSSSFLVWK DEAFALWLKL
WASLYEPGSQ SAKLLREIHD TYFLVSIVDN DFVNGNIWDL FEASVSPATS P
//
