ID V9FMJ9_PHYPR Unreviewed; 1192 AA.
AC V9FMJ9;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN ORFNames=F443_04527 {ECO:0000313|EMBL:ETI52301.1};
OS Phytophthora parasitica P1569.
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=1317065 {ECO:0000313|EMBL:ETI52301.1, ECO:0000313|Proteomes:UP000018721};
RN [1] {ECO:0000313|EMBL:ETI52301.1, ECO:0000313|Proteomes:UP000018721}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=P1569 {ECO:0000313|EMBL:ETI52301.1,
RC ECO:0000313|Proteomes:UP000018721};
RG The Broad Institute Genomics Platform;
RA Russ C., Tyler B., Panabieres F., Shan W., Tripathy S., Grunwald N.,
RA Machado M., Johnson C.S., Arredondo F., Hong C., Coffey M., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Phytophthora parasitica P1569.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the helicase family. RecQ subfamily.
CC {ECO:0000256|ARBA:ARBA00005446}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETI52301.1}.
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DR EMBL; ANIZ01000825; ETI52301.1; -; Genomic_DNA.
DR AlphaFoldDB; V9FMJ9; -.
DR EnsemblProtists; ETI52301; ETI52301; F443_04527.
DR OrthoDB; 54635at2759; -.
DR Proteomes; UP000018721; Unassembled WGS sequence.
DR GO; GO:0043138; F:3'-5' DNA helicase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR CDD; cd17920; DEXHc_RecQ; 1.
DR CDD; cd18794; SF2_C_RecQ; 1.
DR Gene3D; 1.10.150.80; HRDC domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR004589; DNA_helicase_ATP-dep_RecQ.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR010997; HRDC-like_sf.
DR InterPro; IPR002121; HRDC_dom.
DR InterPro; IPR044876; HRDC_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR032284; RecQ_Zn-bd.
DR InterPro; IPR001763; Rhodanese-like_dom.
DR InterPro; IPR018982; RQC_domain.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR NCBIfam; TIGR00614; recQ_fam; 1.
DR PANTHER; PTHR13710:SF153; ATP-DEPENDENT DNA HELICASE Q-LIKE 4A; 1.
DR PANTHER; PTHR13710; DNA HELICASE RECQ FAMILY MEMBER; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00570; HRDC; 1.
DR Pfam; PF16124; RecQ_Zn_bind; 1.
DR Pfam; PF09382; RQC; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00341; HRDC; 1.
DR SMART; SM00956; RQC; 1.
DR SUPFAM; SSF47819; HRDC-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS50967; HRDC; 1.
DR PROSITE; PS50206; RHODANESE_3; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000018721}.
FT DOMAIN 400..576
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 590..753
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 601..665
FT /note="Rhodanese"
FT /evidence="ECO:0000259|PROSITE:PS50206"
FT DOMAIN 1007..1087
FT /note="HRDC"
FT /evidence="ECO:0000259|PROSITE:PS50967"
FT REGION 72..129
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 170..206
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 922..964
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1166..1192
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 211..269
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 112..129
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 940..962
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1166..1180
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1192 AA; 132315 MW; 4511E52BD95A5FD2 CRC64;
MCILYPSVVL SSSDGTADKE NCLETIQRGR DALLKFQALR ARSKASTKLK VVPTPRIALG
TIPVINTAPI PAPIDTSRQY GDSSAGRGRN GADYAPSAAG FQPAPAASDV VDLTGTTPSS
PSRANTGYQN NRTTISARSA VQQTSFTGMD DDTDSLFDDV DVDALVANHQ RVQQQKRRGA
PQVPSLSKES FVSPPSTQTN GSQETASAML AEDLRQSIKQ TRENLRKVRE ECDDASLEGE
VPEFMQKRRS ELEQELEELS RRYRECKGTT KASPQSRNVS PVQIPPRAVQ TPQSYQCGGD
SSNKNPMCSC GMTTVEARVQ HGANANRLYY RCNTCGFHSW VDAASSSGGN SGVHQTRPRA
IEQPCVSSDP SVNSKMQRAK RVLRDVFGHN SFRPNQERTV MEAFSGRDVF VLMPTGGGKS
LCFQLPACID DGVTIVISPL VSLIQDQVQQ LEALDVGVAN LKGDQDYATE QRPIISELFS
NQIRIKMLYV TPEKIASSGM LNNLFESLEK RGLLARFVID EAHCISQWGH DFRKDYLNLG
TLRTKFPSVP IMALTATANS QTEADIVRNL KLKNPFITRS SFNRPNLTYD VRKKTSKFMA
EIADFVRKHI DDSGIIYCLS KKDCEQTAEK LIKALGFEHT RKASQISFYH AGLEAADRAY
RHHEWSKGKI KLICATVAFG MGINKPDVRY VIHHTIPQSV THYYQEAGRA GRDGEVANCI
LYYSFLDLTR RRKLITKDRE NMQHRNVHLQ NLRRMTEFCE NQVECRRTSL LEYFGEHFSS
EQCHGTCDNC KNKVLGISFE KSDVTEDCVA LAEMIKALQA NGDPATLVQI AQIFLGMVVK
GKEWKQDQFS QLGGFGRGKG RYSRSEVERI LYHMILRQYL REVDQSNAKG FTTTFLSLGI
NSNRLMRGER VRIVCKTKYQ SRASASDGAP EESTKTSKKK AQKKTIASKK TKKPSKTIKK
KKASAKNVVE ELSDDYDDDV VEVAPPSATT TEYPLIPERI SSRRIPEDHA ETLAQILKDW
RASVCDSQNV MPYHILTTGG IASIANSVPV SNAELLEIDG VGRIRVKKYG AAIIDIVKTY
LEKNNLTPSP VQASRSSNVL DSLEVLDSGV EVVQAPAAPK SSPFFQDKTK RKTSLTSSKT
ASHAVIDDNF DDIDWGELDA DMLNQTSSKA VTNGRKRSLD SDTTWTAKKR SN
//
