ID V9FW54_PHYPR Unreviewed; 1492 AA.
AC V9FW54;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=SSD domain-containing protein {ECO:0000259|PROSITE:PS50156};
GN ORFNames=F443_02606 {ECO:0000313|EMBL:ETI54642.1};
OS Phytophthora parasitica P1569.
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=1317065 {ECO:0000313|EMBL:ETI54642.1, ECO:0000313|Proteomes:UP000018721};
RN [1] {ECO:0000313|EMBL:ETI54642.1, ECO:0000313|Proteomes:UP000018721}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=P1569 {ECO:0000313|EMBL:ETI54642.1,
RC ECO:0000313|Proteomes:UP000018721};
RG The Broad Institute Genomics Platform;
RA Russ C., Tyler B., Panabieres F., Shan W., Tripathy S., Grunwald N.,
RA Machado M., Johnson C.S., Arredondo F., Hong C., Coffey M., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Phytophthora parasitica P1569.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the patched family.
CC {ECO:0000256|ARBA:ARBA00005585}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETI54642.1}.
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DR EMBL; ANIZ01000460; ETI54642.1; -; Genomic_DNA.
DR EnsemblProtists; ETI54642; ETI54642; F443_02606.
DR eggNOG; KOG1933; Eukaryota.
DR HOGENOM; CLU_002359_7_0_1; -.
DR OrthoDB; 2786103at2759; -.
DR Proteomes; UP000018721; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015918; P:sterol transport; IEA:UniProt.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR032190; NPC1_N.
DR InterPro; IPR003392; Ptc/Disp.
DR InterPro; IPR000731; SSD.
DR PANTHER; PTHR45727; NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1; 1.
DR PANTHER; PTHR45727:SF2; NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1; 1.
DR Pfam; PF16414; NPC1_N; 1.
DR Pfam; PF02460; Patched; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018721};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..1492
FT /note="SSD domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004775428"
FT TRANSMEM 401..421
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 488..506
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 762..779
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 791..815
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 821..845
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 883..906
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 912..940
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1021..1039
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1059..1081
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1315..1333
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1370..1389
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1409..1431
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1443..1466
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 757..940
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT REGION 965..993
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 965..979
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1492 AA; 164435 MW; EB9C6A2A0CC6D9FD CRC64;
MRVSTFAALL LPMGGVVAQT TTSTSTTATT STTATATATA SSGTSSVSSY VPWTLADNAT
VLADLRSQLT MCSYSKVEEC IHDPALVHEL GVLVRAPGHC VAFDSSYVNV TTPSAAIPNR
YYPTSVEDAY DAGFSNKFSE WSDSNREQFE VDCPLLYNQT IAQGDDMLCC TESQYTGLST
QVRMIPGLCS ACKENLRNIF CQMTCSPNNS LFLDVNEVRI MGGDDEHADA VFPAVEELTY
YVGNDWIRDI YDFCEDDSSF SLLCNPNQDC HDGYGLMEYM GKYAYNSIGS PLQINVTTMD
KMPELTQMTE FCHCDNVNAT NCILPMNNKM TSCVGVCGSL CAVSSDDDRT YTESCYGAVS
AVATSASGSG SAGSGDDSTW AELNAYLAAN IPVTDWEPLN YFLVIFGAVV ALLLIVGFIV
AGCRERRSRI PNPHTGTPQI GPYTPEAHGV AHAMETNTKR LSYLDELMTN KLRNWAVFVS
TGNRPKKIIP CVLCVVAVCC IGLYNIEIET DPIKLWVSTS STSYQERQHY GDLFNPFYRS
EQLIMVPKDG GNIYRSAILK EAIRVQNVAA DVVYTSDDGE TITLDDICWK ATGTGCTINS
ITQYFQNNME HFEFYEKYGL ELEHFSNCLY SPTTSDVALC TELKNALEDG DSLPSTMSDC
PCLSTFGSPM NLYNTYLGGF PDGAESNYTL FLDSIAFVSS YLNYNYADDD KNEPAIKWER
EYIKTMKKEA ESNSVFNVYF YAEISVQDEV DAESSNGMGP VALSYCLMII YISLGINRIK
FGREFFISSK IVAGFCGVMS IVCGVASTIG LYMWFGVKLQ LIIMEVVPFL SLAIGVDNIF
LLIHAMTEKE DQMRREQPSL FVGLEHNPKA IEEITTTIVS ESLAYIGPSI FMASAAESVA
FAFGSISAMP VVLWFAAMAC CAVAINFCFQ MTLFLSVLTL DKRRELSGKY DIIFKRASYV
RSQAPAAGPQ TQQTAEPLVS FEPKTPAPED VRRSVTPENR TLTDVLDHCV DVYASFLTYK
LVKLVVLLAF LGWTLWSIYS MESLDQGLPQ KEAMPSDSYM IEYFNALDVY LATGVPVYFI
VETGYGRNPE KWSLNDESVE TIFCKSKDIC GTYSIPNIMN ALANHGDKTV THISPGTTYS
WMDDYWGFVN PDSECCRVDS EGAYVPIESG NDTYTTLRAE AGTCLATSVT VPPVPEAQYM
SLFSMFATAS AGTSCSYGGG SIYRGQFSID DEPIPTVNAS TPAVKINSSG YGDEITAWSY
MVTGTSNPTQ QRYIDSYKQN LAAAEWISEK TGVDIWVYSL TYVYFEQYLT VIEDAYRLIG
LALAAIFVIT TLYLGSVFYA LTIALMATNL VVLVLGLMQP LDIMLNGLSI VNLIIAAGIA
VEFCGHYVRF FAKAQGTGDE RARDALRQVF TSVIFGITIT KVIGLSVLTL ADSRVFKKYY
FRMYMMVVLC GVLNGMLLLP VLLSTITDVR NFFLRRGSQK TELRSAPVTR VD
//