ID   V9G2J1_PHYPR            Unreviewed;       461 AA.
AC   V9G2J1;
DT   19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT   19-FEB-2014, sequence version 1.
DT   24-JAN-2024, entry version 27.
DE   SubName: Full=Argininosuccinate lyase {ECO:0000313|EMBL:ETI57691.1};
GN   ORFNames=F443_00049 {ECO:0000313|EMBL:ETI57691.1};
OS   Phytophthora parasitica P1569.
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC   Phytophthora.
OX   NCBI_TaxID=1317065 {ECO:0000313|EMBL:ETI57691.1, ECO:0000313|Proteomes:UP000018721};
RN   [1] {ECO:0000313|EMBL:ETI57691.1, ECO:0000313|Proteomes:UP000018721}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=P1569 {ECO:0000313|EMBL:ETI57691.1,
RC   ECO:0000313|Proteomes:UP000018721};
RG   The Broad Institute Genomics Platform;
RA   Russ C., Tyler B., Panabieres F., Shan W., Tripathy S., Grunwald N.,
RA   Machado M., Johnson C.S., Arredondo F., Hong C., Coffey M., Young S.K.,
RA   Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L.,
RA   Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA   Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA   Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA   Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Phytophthora parasitica P1569.";
RL   Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the lyase 1 family. Argininosuccinate lyase
CC       subfamily. {ECO:0000256|ARBA:ARBA00010755}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ETI57691.1}.
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DR   EMBL; ANIZ01000011; ETI57691.1; -; Genomic_DNA.
DR   AlphaFoldDB; V9G2J1; -.
DR   EnsemblProtists; ETI57691; ETI57691; F443_00049.
DR   eggNOG; KOG1316; Eukaryota.
DR   HOGENOM; CLU_027272_2_1_1; -.
DR   OrthoDB; 2722228at2759; -.
DR   Proteomes; UP000018721; Unassembled WGS sequence.
DR   GO; GO:0004056; F:argininosuccinate lyase activity; IEA:InterPro.
DR   GO; GO:0042450; P:arginine biosynthetic process via ornithine; IEA:InterPro.
DR   CDD; cd01359; Argininosuccinate_lyase; 1.
DR   Gene3D; 1.10.40.30; Fumarase/aspartase (C-terminal domain); 1.
DR   Gene3D; 1.20.200.10; Fumarase/aspartase (Central domain); 1.
DR   Gene3D; 1.10.275.10; Fumarase/aspartase (N-terminal domain); 1.
DR   HAMAP; MF_00006; Arg_succ_lyase; 1.
DR   InterPro; IPR029419; Arg_succ_lyase_C.
DR   InterPro; IPR009049; Argininosuccinate_lyase.
DR   InterPro; IPR024083; Fumarase/histidase_N.
DR   InterPro; IPR020557; Fumarate_lyase_CS.
DR   InterPro; IPR000362; Fumarate_lyase_fam.
DR   InterPro; IPR022761; Fumarate_lyase_N.
DR   InterPro; IPR008948; L-Aspartase-like.
DR   NCBIfam; TIGR00838; argH; 1.
DR   PANTHER; PTHR43814; ARGININOSUCCINATE LYASE; 1.
DR   PANTHER; PTHR43814:SF1; ARGININOSUCCINATE LYASE; 1.
DR   Pfam; PF14698; ASL_C2; 1.
DR   Pfam; PF00206; Lyase_1; 1.
DR   PRINTS; PR00145; ARGSUCLYASE.
DR   PRINTS; PR00149; FUMRATELYASE.
DR   SUPFAM; SSF48557; L-aspartase-like; 1.
DR   PROSITE; PS00163; FUMARATE_LYASES; 1.
PE   3: Inferred from homology;
KW   Lyase {ECO:0000313|EMBL:ETI57691.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018721}.
FT   DOMAIN          14..306
FT                   /note="Fumarate lyase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00206"
FT   DOMAIN          369..436
FT                   /note="Argininosuccinate lyase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF14698"
SQ   SEQUENCE   461 AA;  50828 MW;  AF00EC67ABE296B7 CRC64;
     MTDAPKEAKK LWGGRFRGNV DPVMNKFNES LSVDKRMWRV DLDGSQAYAR ALEKSGVLTT
     AEVDQIVAGL DKVGEEWAAG TFQPKDGDED IHTANERRLT EIIGAVGGKL HTGRSRNDQV
     ATDVRLYLKR TIVGIQDGLK ELIGTANQLA ENNIDLLMPG FTHLQPAQPL RFSHWVLSHG
     AALLRDADRL ADLTKRVDYM PLGNGALAGN SFGLDREALA KSLGFANVTP NSLDGVCDRD
     FIAEFLFWAS MLMVHLSQLS EDLIIYNTLK FVTMADAYST GSSLMPQKKN PDALELLRGK
     SGTVIGRLNG FLVTLKGLPR SYNKDLQEDK TALFDVVDTI QDCLQIATGV LATMTPHGDK
     MRSFLVTEML ATDLAEYLVR KGVPFRETHH VAGAAVRLAE DKNKPLSTLT FEELSTLHPK
     FEEDVLEVWN FDVSVERKNV TGGTSKSAVQ KQIADIKAWL A
//