ID V9G609_9BACL Unreviewed; 638 AA.
AC V9G609;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE SubName: Full=Squalene-hopene cyclase {ECO:0000313|EMBL:GAE05298.1};
GN ORFNames=JCM10914_1394 {ECO:0000313|EMBL:GAE05298.1};
OS Paenibacillus sp. JCM 10914.
OC Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae; Paenibacillus.
OX NCBI_TaxID=1236974 {ECO:0000313|EMBL:GAE05298.1, ECO:0000313|Proteomes:UP000018028};
RN [1] {ECO:0000313|EMBL:GAE05298.1, ECO:0000313|Proteomes:UP000018028}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCM 10914 {ECO:0000313|EMBL:GAE05298.1,
RC ECO:0000313|Proteomes:UP000018028};
RA Ohkuma M., Yuki M., Oshima K., Suda W., Oshida Y., Kitamura K., Iida T.,
RA Hattori M.;
RT "Draft Genome Sequence of the Alkaliphilic and Xylanolytic Paenibacillus
RT sp. Strain JCM 10914, Isolated from the Gut of a Soil-Feeding Termite.";
RL Genome Announc. 2:e01144-13(2014).
CC -!- PATHWAY: Secondary metabolite biosynthesis; hopanoid biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004999}.
CC -!- SIMILARITY: Belongs to the terpene cyclase/mutase family.
CC {ECO:0000256|ARBA:ARBA00009755}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAE05298.1}.
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DR EMBL; BAUO01000003; GAE05298.1; -; Genomic_DNA.
DR AlphaFoldDB; V9G609; -.
DR STRING; 1236974.GCA_001315105_01364; -.
DR UniPathway; UPA00337; -.
DR Proteomes; UP000018028; Unassembled WGS sequence.
DR GO; GO:0005811; C:lipid droplet; IEA:InterPro.
DR GO; GO:0016866; F:intramolecular transferase activity; IEA:InterPro.
DR GO; GO:0016104; P:triterpenoid biosynthetic process; IEA:InterPro.
DR Gene3D; 1.50.10.20; -; 2.
DR InterPro; IPR006400; Hopene-cyclase.
DR InterPro; IPR032696; SQ_cyclase_C.
DR InterPro; IPR032697; SQ_cyclase_N.
DR InterPro; IPR018333; Squalene_cyclase.
DR InterPro; IPR002365; Terpene_synthase_CS.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR NCBIfam; TIGR01507; hopene_cyclase; 1.
DR NCBIfam; TIGR01787; squalene_cyclas; 1.
DR PANTHER; PTHR11764:SF20; LANOSTEROL SYNTHASE; 1.
DR PANTHER; PTHR11764; TERPENE CYCLASE/MUTASE FAMILY MEMBER; 1.
DR Pfam; PF13243; SQHop_cyclase_C; 1.
DR Pfam; PF13249; SQHop_cyclase_N; 1.
DR SFLD; SFLDG01016; Prenyltransferase_Like_2; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 2.
DR PROSITE; PS01074; TERPENE_SYNTHASES; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000018028};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 14..294
FT /note="Squalene cyclase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF13249"
FT DOMAIN 309..628
FT /note="Squalene cyclase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13243"
SQ SEQUENCE 638 AA; 71997 MW; 3B0D5F9870010AFE CRC64;
MDEMHVAVEA EIYKLTDFLI QKQQRDGSWH FCFENGVAVD AYVLMLFRIL DIQNETLVRQ
LHDRVMAEQQ PGGDWRWYYD EHEGNLSASI DAYHALLYSG YSRPEDEHMV RARRYIQSQG
GLAKASGVLT KAILAATGQR TWPKSISVIP VELVLFPDYM PINLYEFSGY SRVHLIPMLI
MADLNFSITS EWAPDLSDLQ ISRHIEEEEE HQEHREIIDS IRVGIRRLLG SPRSIHEAAL
RKAERFMLDR IESDGTLYSY ASTTVLMVLA LLALGYDKQH PVIMRAVQGL TSLQFRLNFK
ATTIQNSPST IWDTALITYA LQESGIVEDH PSVRRAADYL LARQHDKTAD WSVHNRGTVP
GGWGFSESNT LNPDVDDTTA ALRAIHGLSY NDPDQVYQHA ASRGLNWVIS MQNKNGGWPA
FEKNTDKEML TWLAIDGAKS AAIDPSGADL TGRTLEYLGR FCGFSTEHLF IKRGAEWLIS
NQEQDGSWYG RWGICYIYGT WAAVTGLRAT GIPADHPTIR KAADWLLHIQ NPDGGWGESC
TSDRLMRYVP LGASNPSQTA WALDALISVQ SEPSPAVIKG MGTLIELLHV NDWRTEYPMG
AGLPGSFYTH YHSYRYIWSL LALGHYKQKY GKQGVLHS
//
