ID V9GXZ5_HUMAN Unreviewed; 910 AA.
AC V9GXZ5;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Ubiquitin specific peptidase 43 {ECO:0000313|Ensembl:ENSP00000459328.3};
DE Flags: Fragment;
GN Name=USP43 {ECO:0000313|Ensembl:ENSP00000459328.3};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000459328.3, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000459328.3, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [2] {ECO:0007829|PubMed:18669648}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [3] {ECO:0007829|PubMed:23186163}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=23186163;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [4] {ECO:0000313|Ensembl:ENSP00000459328.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AC027045; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC118755; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR MassIVE; V9GXZ5; -.
DR MaxQB; V9GXZ5; -.
DR PeptideAtlas; V9GXZ5; -.
DR Antibodypedia; 6274; 162 antibodies from 25 providers.
DR Ensembl; ENST00000574408.5; ENSP00000459328.3; ENSG00000154914.17.
DR UCSC; uc060ber.1; human.
DR HGNC; HGNC:20072; USP43.
DR VEuPathDB; HostDB:ENSG00000154914; -.
DR GeneTree; ENSGT00940000158772; -.
DR ChiTaRS; USP43; human.
DR Proteomes; UP000005640; Chromosome 17.
DR Bgee; ENSG00000154914; Expressed in oviduct epithelium and 158 other cell types or tissues.
DR ExpressionAtlas; V9GXZ5; baseline and differential.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:InterPro.
DR CDD; cd02674; Peptidase_C19R; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001394; Peptidase_C19_UCH.
DR InterPro; IPR018200; USP_CS.
DR InterPro; IPR028889; USP_dom.
DR PANTHER; PTHR21646; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR PANTHER; PTHR21646:SF20; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 43; 1.
DR Pfam; PF00443; UCH; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS00973; USP_2; 1.
DR PROSITE; PS50235; USP_3; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|EPD:V9GXZ5,
KW ECO:0007829|MaxQB:V9GXZ5};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT DOMAIN 1..497
FT /note="USP"
FT /evidence="ECO:0000259|PROSITE:PS50235"
FT REGION 589..609
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 634..701
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 730..780
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 796..839
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 858..886
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 743..768
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|Ensembl:ENSP00000459328.3"
SQ SEQUENCE 910 AA; 100476 MW; 698FC91369F1834C CRC64;
XAIPSTTPWN SCSGCWIVYM RTWRVHPEGR CRRRSSLTCP HCLKQSNTFD PFLCVSLPIP
LRQTRFLSVT LVFPSKSQRF LRVGLAVPIL STVAALRKMV AEEGGVPADE VILVELYPSG
FQRSFFDEED LNTIAEGDNV YAFQVPPSPS QGTLSAHPLG LSASPRLAAR EGQRFSLSLH
SESKVLILFC NLVGSGQQAS RFGPPFLIRE DRAVSWAQLQ QSILSKVRHL MKSEAPVQNL
GSLFSIRVVG LSVACSYLSP KDSRPLCHWA VDRVLHLRRP GGPPHVKLAV EWDSSVKERL
FGSLQEERAQ DADSVWQQQQ AHQQHSCTLD ECFQFYTKEE QLAQDDAWKC PHCQVLQQGM
VKLSLWTLPD ILIIHLKRFC QVGERRNKLS TLVKFPLSGL NMAPHVAQRS TSPEAGLGPW
PSWKQPDCLP TSYPLDFLYD LYAVCNHHGN LQGGHYTAYC RNSLDGQWYS YDDSTVEPLR
EDEVNTRGAY ILFYQKRNSI PPWSASSSMR GSTSSSLSDH WLLRLGSHAG STRGSLLSWS
SAPCPSLPQV PDSPIFTNSL CNQEKGGLEP RRLVRGVKGR SISMKAPTTS RAKQGPFKTM
PLRWSFGSKE KPPGASVELV EYLESRRRPR STSQSIVSLL TGTAGEDEKS ASPRSNVALP
ANSEDGGRAI ERGPAGVPCP SAQPNHCLAP GNSDGPNTAR KLKENAGQDI KLPRKFDLPL
TVMPSVEHEK PARPEGQKAM NWKESFQMGS KSSPPSPYMG FSGNSKDSRR GTSELDRPLQ
GTLTLLRSVF RKKENRRNER AEVSPQVPPV SLVSGGLSPA MDGQAPGSPP ALRIPEGLAR
GLGSRLERDV WSAPSSLRLP RKASRAPRGS ALGMSQRTVP GEQASYGTFQ RVKYHTLSLG
RKKTLPESSF
//
