ID V9H441_9CLOT Unreviewed; 874 AA.
AC V9H441;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE RecName: Full=Aldehyde-alcohol dehydrogenase {ECO:0000256|PIRNR:PIRNR000111};
GN ORFNames=CSBG_01867 {ECO:0000313|EMBL:EEH98241.1};
OS Clostridium sp. 7_2_43FAA.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=457396 {ECO:0000313|EMBL:EEH98241.1, ECO:0000313|Proteomes:UP000017809};
RN [1] {ECO:0000313|EMBL:EEH98241.1, ECO:0000313|Proteomes:UP000017809}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=7_2_43FAA {ECO:0000313|EMBL:EEH98241.1,
RC ECO:0000313|Proteomes:UP000017809};
RG The Broad Institute Genome Sequencing Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Allen-Vercoe E., Strauss J.,
RA Ambrose C., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA Abouelleil A., Alvarado L., Arachchi H.M., Berlin A., Chapman S.B.,
RA Gearin G., Goldberg J., Griggs A., Gujja S., Hansen M., Heiman D.,
RA Howarth C., Larimer J., Lui A., MacDonald P.J.P., McCowen C.,
RA Montmayeur A., Murphy C., Neiman D., Pearson M., Priest M., Roberts A.,
RA Saif S., Shea T., Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Clostridium sp. 7_2_43FAA.";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: In the C-terminal section; belongs to the iron-containing
CC alcohol dehydrogenase family. {ECO:0000256|ARBA:ARBA00035645,
CC ECO:0000256|PIRNR:PIRNR000111}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the aldehyde
CC dehydrogenase family. {ECO:0000256|ARBA:ARBA00035641,
CC ECO:0000256|PIRNR:PIRNR000111}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EEH98241.1}.
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DR EMBL; ACDK02000018; EEH98241.1; -; Genomic_DNA.
DR RefSeq; WP_008678258.1; NZ_JH815222.1.
DR AlphaFoldDB; V9H441; -.
DR STRING; 457396.CSBG_01867; -.
DR GeneID; 65398779; -.
DR eggNOG; COG1012; Bacteria.
DR eggNOG; COG1454; Bacteria.
DR HOGENOM; CLU_007207_1_1_9; -.
DR OrthoDB; 9804734at2; -.
DR Proteomes; UP000017809; Unassembled WGS sequence.
DR GO; GO:0008774; F:acetaldehyde dehydrogenase (acetylating) activity; IEA:UniProtKB-UniRule.
DR GO; GO:1990362; F:butanol dehydrogenase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0006066; P:alcohol metabolic process; IEA:InterPro.
DR GO; GO:0015976; P:carbon utilization; IEA:InterPro.
DR CDD; cd08178; AAD_C; 1.
DR CDD; cd07122; ALDH_F20_ACDH; 1.
DR Gene3D; 3.40.50.1970; -; 1.
DR Gene3D; 1.20.1090.10; Dehydroquinate synthase-like - alpha domain; 1.
DR InterPro; IPR034789; AAD_C.
DR InterPro; IPR001670; ADH_Fe/GldA.
DR InterPro; IPR018211; ADH_Fe_CS.
DR InterPro; IPR016161; Ald_DH/histidinol_DH.
DR InterPro; IPR016163; Ald_DH_C.
DR InterPro; IPR016162; Ald_DH_N.
DR InterPro; IPR015590; Aldehyde_DH_dom.
DR InterPro; IPR044731; BDH-like.
DR InterPro; IPR012079; Bifunc_Ald-ADH.
DR PANTHER; PTHR43633; ALCOHOL DEHYDROGENASE YQHD; 1.
DR PANTHER; PTHR43633:SF1; ALCOHOL DEHYDROGENASE YQHD; 1.
DR Pfam; PF00171; Aldedh; 1.
DR Pfam; PF00465; Fe-ADH; 1.
DR PIRSF; PIRSF000111; ALDH_ADH; 1.
DR SUPFAM; SSF53720; ALDH-like; 1.
DR SUPFAM; SSF56796; Dehydroquinate synthase-like; 1.
DR PROSITE; PS00060; ADH_IRON_2; 1.
PE 3: Inferred from homology;
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|PIRNR:PIRNR000111};
KW Reference proteome {ECO:0000313|Proteomes:UP000017809}.
FT DOMAIN 4..399
FT /note="Aldehyde dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF00171"
FT DOMAIN 456..846
FT /note="Alcohol dehydrogenase iron-type/glycerol
FT dehydrogenase GldA"
FT /evidence="ECO:0000259|Pfam:PF00465"
SQ SEQUENCE 874 AA; 96113 MW; FAEC5BF353067736 CRC64;
MAVTNAKELT QRIKELREAQ RVFATYTQEQ VDEIFRQAAM AANDNRIKLA KMAVAETGMG
IVEDKVIKNH FAAEYIYNQY KDMKTCGVLE EDKTFGITKV AEPIGVISAI VPTTNPTSTA
IFKTLIALKT RNAIIISPHP RAKKATIEAA RIVLEAAVKA GAPEGIIGWI DEPSVELSQN
VMRESDIILA TGGPAMVKAA YSSGRPALGV GAGNTPAIID ETAHIKMAVN SILLSKTFDN
GVICASEQSL VVLDQVYDEV KNELSDRGAY ILKGEEVDKV RKIILNEKGG LNANIVGQSA
YKIAEMAGVN VPTTAKVLVG EVESVELEEP FSHEKLSPIL AMYRVKSYEE ALEKANRLIE
LGGMGHTSIL YTDQLKSRDR ILQFGEKMKT ARTLINMPAS QGAIGDIFNF KLAPSLTLGC
GSWGGNSVSE NVGPKHLINV KSIAERRENM LWFRVPEKVY FKYGCLPVAL EELRDMGKKK
ALIVTDKVLF EMGYTNKVTD VLERNGIQFK IFSDVEPDPT LRCAKAGAKE MLDFNPDVII
ALGGGSAMDA AKIMWVMYEH PEVRFEDLAM RFMDIRKRVY KFPTMGEKAM MVSIATSAGT
GSEVTPFAVI TDENTGVKYP LADYELTPDM AIVDAELMMT SPKGLTACAG IDVLVHSIEA
YVSIMASEYT NGLALEAIRL VFKYLPDAYN EGTTNVKARE KMAHASCMAG MAFSNAFLGI
THSMAHKLGA FHHLPHGMAN SLLMNEVIRF NATDAPTKQA AFAQYKYPNA AWRYARIADH
LGLGGNSEVE KVELLIKAIE KLQAKVNMPK TIKEAGVSET KFYETLDEMV EQAFDDQCTG
ANPRYPLMSE LKEMYITAYE GPKTKEVKKE TKKK
//