ID V9H7X9_9CLOT Unreviewed; 968 AA.
AC V9H7X9;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=DNA topoisomerase (ATP-hydrolyzing) {ECO:0000256|ARBA:ARBA00012895};
DE EC=5.6.2.2 {ECO:0000256|ARBA:ARBA00012895};
GN ORFNames=CSBG_02037 {ECO:0000313|EMBL:EEH98411.1};
OS Clostridium sp. 7_2_43FAA.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=457396 {ECO:0000313|EMBL:EEH98411.1, ECO:0000313|Proteomes:UP000017809};
RN [1] {ECO:0000313|EMBL:EEH98411.1, ECO:0000313|Proteomes:UP000017809}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=7_2_43FAA {ECO:0000313|EMBL:EEH98411.1,
RC ECO:0000313|Proteomes:UP000017809};
RG The Broad Institute Genome Sequencing Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Allen-Vercoe E., Strauss J.,
RA Ambrose C., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA Abouelleil A., Alvarado L., Arachchi H.M., Berlin A., Chapman S.B.,
RA Gearin G., Goldberg J., Griggs A., Gujja S., Hansen M., Heiman D.,
RA Howarth C., Larimer J., Lui A., MacDonald P.J.P., McCowen C.,
RA Montmayeur A., Murphy C., Neiman D., Pearson M., Priest M., Roberts A.,
RA Saif S., Shea T., Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Clostridium sp. 7_2_43FAA.";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-dependent breakage, passage and rejoining of double-
CC stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000256|ARBA:ARBA00000185};
CC -!- SIMILARITY: Belongs to the type II topoisomerase GyrA/ParC subunit
CC family. {ECO:0000256|ARBA:ARBA00008263}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EEH98411.1}.
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DR EMBL; ACDK02000016; EEH98411.1; -; Genomic_DNA.
DR RefSeq; WP_008677984.1; NZ_JH815222.1.
DR AlphaFoldDB; V9H7X9; -.
DR STRING; 457396.CSBG_02037; -.
DR GeneID; 65398610; -.
DR eggNOG; COG0188; Bacteria.
DR HOGENOM; CLU_002977_5_0_9; -.
DR OrthoDB; 9806486at2; -.
DR Proteomes; UP000017809; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003918; F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity; IEA:UniProtKB-EC.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd00187; TOP4c; 1.
DR Gene3D; 3.30.1360.40; -; 1.
DR Gene3D; 2.120.10.90; DNA gyrase/topoisomerase IV, subunit A, C-terminal; 2.
DR Gene3D; 3.90.199.10; Topoisomerase II, domain 5; 1.
DR Gene3D; 1.10.268.10; Topoisomerase, domain 3; 1.
DR InterPro; IPR006691; GyrA/parC_rep.
DR InterPro; IPR035516; Gyrase/topoIV_suA_C.
DR InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR InterPro; IPR013758; Topo_IIA_A/C_ab.
DR InterPro; IPR013757; Topo_IIA_A_a_sf.
DR InterPro; IPR002205; Topo_IIA_dom_A.
DR PANTHER; PTHR43493:SF5; DNA GYRASE SUBUNIT A, CHLOROPLASTIC_MITOCHONDRIAL; 1.
DR PANTHER; PTHR43493; DNA GYRASE/TOPOISOMERASE SUBUNIT A; 1.
DR Pfam; PF03989; DNA_gyraseA_C; 7.
DR Pfam; PF00521; DNA_topoisoIV; 1.
DR SMART; SM00434; TOP4c; 1.
DR SUPFAM; SSF101904; GyrA/ParC C-terminal domain-like; 2.
DR SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Reference proteome {ECO:0000313|Proteomes:UP000017809};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 17..477
FT /note="DNA topoisomerase type IIA"
FT /evidence="ECO:0000259|SMART:SM00434"
FT COILED 449..490
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 968 AA; 109655 MW; 15CD30E094AB7BEE CRC64;
MAKKVNDIPR DNNIIRVPLE EAMPDNYLPY AIEVAKDRAL PDVRDGLKPV HRRILYGAYQ
LKAFPDRPYY KSARIVGDIL GKYHPHGDTS VYDAMVIMAQ NFSTRETLID GHGNWGSMDG
DGAAAMRYTE ARLAPIAMEM LRDIDKETVD MVPNYSDSEM EPKVLPSRYP NLLVNGTFGI
AVGLATNIPP HNLGEVTDGV LAYIDNSEIT TKELMNYVKG PDLPTGGILI GQNSILAAYE
TGEGKVTLRA KTNIERLENG RVGIVITEFP FRRNKAKLLQ TISEMTGDKR HAKALESIVD
IRDESDRSGV RAVIELRKAA DEEVADKVLK YLFKRTDLQC NLSFNMVALA DGKPQTMGLK
TIIKHYVNHQ KEIVTRRTIK ELSIAEKRFH IVEGFIKAID VLDEIIKTIR ESKSKKDAGV
NLISKFGFTE IQAEAILELM LYRLTGLEIK VFQKEYAELE KTIKKLKKIL SEEKELLKVV
KNELKEVSDK YRNPRKTSII KDDNEAKIDV EELIVVEDVM ITLSKDGFIK RIPLKTFNRL
NAKAEDIEYR EGDELKFLFK SNTTESILLF TNKGNMYQTK GINIPEGKWK EKGEKVDNII
KTLNLEEENI IFATSVTSFI PSKYIQFITS RGGIKRSSLD KFQTSYTKLQ AIKLKELEEV
IDVILLNQEE VKEFISFETK EGLSFSLQIP KIEDLPRNIL PTIMFNLSNK DEIIKVEYSE
TMEFVNFSIG ITSKGTIKGF NSIKKNDNLK VSTDSLSNVL MFTNKGKVFK IPAFLLSGVS
KGELPLDKIV DNIEKDEKVI KVFSLKTFEE NKFIYFFTRR GMIKKTALTE FDGNYSTQIT
YKFKYDNDEL ISVELYDDCQ VEMLIITKKA MGIKFSSENV NTMGKVASGV TGISLKENDE
VIYGSLIGSQ SRDNTNEIAL TSTDKITLIS KNKEKKEVEL EDIKLQNRAG KGSSIMTISL
EDEIKEII
//
