ID   V9HGC1_9CLOT            Unreviewed;       747 AA.
AC   V9HGC1;
DT   19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT   19-FEB-2014, sequence version 1.
DT   27-MAR-2024, entry version 49.
DE   RecName: Full=UvrD-like helicase ATP-binding domain-containing protein {ECO:0000259|PROSITE:PS51198};
GN   ORFNames=CSBG_01617 {ECO:0000313|EMBL:EEH97991.1};
OS   Clostridium sp. 7_2_43FAA.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=457396 {ECO:0000313|EMBL:EEH97991.1, ECO:0000313|Proteomes:UP000017809};
RN   [1] {ECO:0000313|EMBL:EEH97991.1, ECO:0000313|Proteomes:UP000017809}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=7_2_43FAA {ECO:0000313|EMBL:EEH97991.1,
RC   ECO:0000313|Proteomes:UP000017809};
RG   The Broad Institute Genome Sequencing Platform;
RA   Earl A., Ward D., Feldgarden M., Gevers D., Allen-Vercoe E., Strauss J.,
RA   Ambrose C., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA   Abouelleil A., Alvarado L., Arachchi H.M., Berlin A., Chapman S.B.,
RA   Gearin G., Goldberg J., Griggs A., Gujja S., Hansen M., Heiman D.,
RA   Howarth C., Larimer J., Lui A., MacDonald P.J.P., McCowen C.,
RA   Montmayeur A., Murphy C., Neiman D., Pearson M., Priest M., Roberts A.,
RA   Saif S., Shea T., Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Clostridium sp. 7_2_43FAA.";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EEH97991.1}.
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DR   EMBL; ACDK02000026; EEH97991.1; -; Genomic_DNA.
DR   RefSeq; WP_008678650.1; NZ_JH815222.1.
DR   AlphaFoldDB; V9HGC1; -.
DR   STRING; 457396.CSBG_01617; -.
DR   GeneID; 65399029; -.
DR   eggNOG; COG3973; Bacteria.
DR   HOGENOM; CLU_010312_4_0_9; -.
DR   OrthoDB; 9787585at2; -.
DR   Proteomes; UP000017809; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR048228; HelD_bacillota.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   NCBIfam; NF041464; HelD_BACSU; 1.
DR   PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR   PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR   Pfam; PF00580; UvrD-helicase; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000017809}.
FT   DOMAIN          209..592
FT                   /note="UvrD-like helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51198"
FT   BINDING         230..237
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ   SEQUENCE   747 AA;  87953 MW;  2A633A675232DDBF CRC64;
     MNSSNYEWNL ENEWLQDVLK EVKKQFDKKH NFKERFRKEA IETQKQLWED VGSVSVINGL
     DQIVDFMEFI NTMKIQKRRH EFTRKLEEKY EKMLLSPYFA RIDFTEEGKD LPGKYYIGIS
     NLINDDFDFL VYDWRAPISS MFYDYEVGKA GYTCPEGVIN GDLTLKRQYK VNDGKLDYMF
     DSNLKIDDEI LQDILAKSSD SKMKAIVTTI QREQNKIIRN QLYKNLIVQG PAGSGKTSVA
     LHRIAYLLYK HREKIGPQNI LIFSPNNIFN DYISDVLPQL GEDNMCQTTF KEYMHKALGN
     EIIKEEYCEM MEYILSSKNE DSYKERIKSI KFKSSKQFLN ILKEYVIYLE KKNRDFKDII
     FKGNLIISSK EIQELYFKDY GHLPLKRRLE KLRERILYLL ETYEKNRVGE VAEDIKNYSS
     QNDETEILKQ SKSVVKNEIK SICSEIYKMT DFNIIDIYKE LFENLERFST LIISEYDDKY
     INEVKFYTLE MIKSKKFNYE DQHALLYLKG SLGDILKISE IKYVIIDEAQ DYTPLQYEIL
     YKLFNNASIT ILGDLNQSIN PFMNLGSYTN ILEIFPKDET CIINLTKSYR STIEITEFSK
     KLLSNNVNYE CVARRGDKPI VLGFSDENNI NEQLLKDIKT YKEKGYKSIG IITKTIKEAQ
     DVHNFLKDKV NVNALLNDED EYVNDTLVIP AFLAKGLEFD VVLIYNAGDE NYDCEEERLL
     LYTACTRALH ILRIYYLGEC TKLLKEK
//