ID V9VVG1_9RHOB Unreviewed; 285 AA.
AC V9VVG1;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Hydroxymethylglutaryl-CoA lyase {ECO:0000313|EMBL:AHD01330.1};
GN ORFNames=METH_12185 {ECO:0000313|EMBL:AHD01330.1};
OS Leisingera methylohalidivorans DSM 14336.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Roseobacteraceae; Leisingera.
OX NCBI_TaxID=999552 {ECO:0000313|EMBL:AHD01330.1, ECO:0000313|Proteomes:UP000018780};
RN [1] {ECO:0000313|EMBL:AHD01330.1, ECO:0000313|Proteomes:UP000018780}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 14336 {ECO:0000313|EMBL:AHD01330.1,
RC ECO:0000313|Proteomes:UP000018780};
RG DOE Joint Genome Institute;
RA Klenk H.-P., Huntemann M., Han J., Chen A., Kyrpides N., Mavromatis K.,
RA Markowitz V., Palaniappan K., Ivanova N., Schaumberg A., Pati A.,
RA Liolios K., Nordberg H.P., Cantor M.N., Hua S.X., Woyke T.;
RL Submitted (SEP-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the HMG-CoA lyase family.
CC {ECO:0000256|ARBA:ARBA00009405}.
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DR EMBL; CP006773; AHD01330.1; -; Genomic_DNA.
DR RefSeq; WP_024090670.1; NC_023135.1.
DR AlphaFoldDB; V9VVG1; -.
DR STRING; 999552.METH_12185; -.
DR KEGG; lmd:METH_12185; -.
DR PATRIC; fig|999552.6.peg.2430; -.
DR HOGENOM; CLU_022138_3_2_5; -.
DR OrthoDB; 9784013at2; -.
DR Proteomes; UP000018780; Chromosome.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016833; F:oxo-acid-lyase activity; IEA:InterPro.
DR CDD; cd07938; DRE_TIM_HMGL; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR043594; HMGL.
DR InterPro; IPR000891; PYR_CT.
DR PANTHER; PTHR42738; HYDROXYMETHYLGLUTARYL-COA LYASE; 1.
DR PANTHER; PTHR42738:SF7; HYDROXYMETHYLGLUTARYL-COA LYASE; 1.
DR Pfam; PF00682; HMGL-like; 1.
DR SUPFAM; SSF51569; Aldolase; 1.
DR PROSITE; PS50991; PYR_CT; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000313|EMBL:AHD01330.1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}.
FT DOMAIN 5..272
FT /note="Pyruvate carboxyltransferase"
FT /evidence="ECO:0000259|PROSITE:PS50991"
SQ SEQUENCE 285 AA; 30039 MW; 65C1B5D1F8FB5DF9 CRC64;
MVERVEIFEV GPRDGLQNEK REIPVAEKVA LTDCLSRAGF SRIEVASFVS PKWVPQMAGS
AEVLAGIARA PGVRYAALTP NMRGYEDAVA AKADEIAVFA SASEGFSKAN INATIEESIM
RFLPILEAAK EIGLPVRGYV SCVTDCPFDG VTAPQKVAEV AERLFALGCY EISLGDTIGR
GTPDAITAML KAVTARVPAK NLAGHYHDTS GRALDNIEAS LDQGVRVFDA AVGGLGGCPY
APGAAGNVAT EAVHRRLTDL GYDTGLDADV LAEAALLARS MRSRQ
//
