ID V9W536_9BACL Unreviewed; 462 AA.
AC V9W536;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=Na(+)/H(+) antiporter NhaC {ECO:0000313|EMBL:AHD04242.1};
GN Name=nhaC1 {ECO:0000313|EMBL:AHD04242.1};
GN ORFNames=ERIC2_c03830 {ECO:0000313|EMBL:AHD04242.1};
OS Paenibacillus larvae subsp. larvae DSM 25430.
OC Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae; Paenibacillus.
OX NCBI_TaxID=697284 {ECO:0000313|EMBL:AHD04242.1, ECO:0000313|Proteomes:UP000029431};
RN [1] {ECO:0000313|EMBL:AHD04242.1, ECO:0000313|Proteomes:UP000029431}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 25430 {ECO:0000313|EMBL:AHD04242.1,
RC ECO:0000313|Proteomes:UP000029431};
RX PubMed=24599066;
RA Djukic M., Brzuszkiewicz E., Funfhaus A., Voss J., Gollnow K., Poppinga L.,
RA Liesegang H., Garcia-Gonzalez E., Genersch E., Daniel R.;
RT "How to Kill the Honey Bee Larva: Genomic Potential and Virulence
RT Mechanisms of Paenibacillus larvae.";
RL PLoS ONE 9:E90914-E90914(2014).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the NhaC Na(+)/H(+) (TC 2.A.35) antiporter
CC family. {ECO:0000256|ARBA:ARBA00038435}.
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DR EMBL; CP003355; AHD04242.1; -; Genomic_DNA.
DR RefSeq; WP_024093085.1; NZ_CP019652.1.
DR AlphaFoldDB; V9W536; -.
DR KEGG; plv:ERIC2_c03830; -.
DR PATRIC; fig|697284.3.peg.371; -.
DR eggNOG; COG1757; Bacteria.
DR HOGENOM; CLU_033405_1_0_9; -.
DR Proteomes; UP000029431; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR InterPro; IPR004770; Na/H_antiport_NhaC.
DR InterPro; IPR018461; Na/H_Antiport_NhaC-like_C.
DR NCBIfam; TIGR00931; antiport_nhaC; 1.
DR PANTHER; PTHR33451; MALATE-2H(+)/NA(+)-LACTATE ANTIPORTER; 1.
DR PANTHER; PTHR33451:SF6; NA(+)_H(+) ANTIPORTER NHAC; 1.
DR Pfam; PF03553; Na_H_antiporter; 1.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000029431};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 12..30
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 36..57
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 69..99
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 196..214
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 226..246
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 253..271
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 309..329
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 349..369
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 427..447
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 157..448
FT /note="Na+/H+ antiporter NhaC-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03553"
SQ SEQUENCE 462 AA; 49263 MW; C54F1EA5C893AABC CRC64;
MKKDVTLKES IFLLVVLLAI IGVCIIGFGV RPQIPILISL GIVILFAAIK GISWDIIHKG
IQNGILPGLI PIIIFMLIGA IVSVWIAAGT IPTIMVYGFS ILSVKFFLPS VFIICSLVGI
TVGSSFTTIS TIGIAFFGMG QIMGFHPALT AGAVISGAFL GNNVSPLSDT TNLASAIAEV
DLFGHIRNML RTVTPAFLIS LLFYIVVGHA NVLSTGSQIE ELVNTLRSSF TISFVPLIPV
FALFLCAWRK IPAIPTLLLS IVITIGIFYI YHPDTSFDQM ARLLQDGYVS QTGVPGVDSL
LTRGGIQSMM WSVSLILLAL ALGGLLVEIR IIETLISRIA GFVGTKGKLI LMTSLSSIGV
NLLLGEQYLS IILPGKAFKS QFDKIKIDLR KLSATLANAG AAVNPLIPWG VSGVFITGTL
GVSTLEYLPY SVYCIAAPLI NIVMGFLGKS KNILKSQGNP SH
//
