ID V9XEK2_9NOCA Unreviewed; 6260 AA.
AC V9XEK2;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 24-JAN-2024, entry version 54.
DE SubName: Full=Peptide synthetase {ECO:0000313|EMBL:AHD21876.1};
GN ORFNames=Y013_10910 {ECO:0000313|EMBL:AHD21148.1}, Y013_15030
GN {ECO:0000313|EMBL:AHD21876.1};
OS Rhodococcus pyridinivorans SB3094.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC Rhodococcus.
OX NCBI_TaxID=1435356 {ECO:0000313|EMBL:AHD21876.1, ECO:0000313|Proteomes:UP000018781};
RN [1] {ECO:0000313|EMBL:AHD21876.1, ECO:0000313|Proteomes:UP000018781}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB3094 {ECO:0000313|EMBL:AHD21876.1,
RC ECO:0000313|Proteomes:UP000018781};
RX PubMed=24874690;
RA Dueholm M.S., Albertsen M., D'Imperio S., Tale V.P., Lewis D.,
RA Nielsen P.H., Nielsen J.L.;
RT "Complete Genome of Rhodococcus pyridinivorans SB3094, a Methyl-Ethyl-
RT Ketone-Degrading Bacterium Used for Bioaugmentation.";
RL Genome Announc. 2:e00525-14(2014).
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR EMBL; CP006996; AHD21148.1; -; Genomic_DNA.
DR EMBL; CP006996; AHD21876.1; -; Genomic_DNA.
DR KEGG; rpy:Y013_10910; -.
DR KEGG; rpy:Y013_15030; -.
DR PATRIC; fig|1435356.3.peg.2186; -.
DR eggNOG; COG1020; Bacteria.
DR HOGENOM; CLU_000022_0_15_11; -.
DR UniPathway; UPA00011; -.
DR Proteomes; UP000018781; Chromosome.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR GO; GO:0019752; P:carboxylic acid metabolic process; IEA:UniProt.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 4.
DR CDD; cd19540; LCL_NRPS-like; 4.
DR Gene3D; 3.30.300.30; -; 6.
DR Gene3D; 3.40.50.980; -; 4.
DR Gene3D; 1.10.1200.10; ACP-like; 5.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 7.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 4.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 6.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR020802; PKS_thioesterase.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR001031; Thioesterase.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 5.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 7.
DR Pfam; PF13193; AMP-binding_C; 5.
DR Pfam; PF00668; Condensation; 6.
DR Pfam; PF00550; PP-binding; 6.
DR Pfam; PF00975; Thioesterase; 1.
DR SMART; SM00823; PKS_PP; 6.
DR SMART; SM00824; PKS_TE; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 6.
DR SUPFAM; SSF47336; ACP-like; 6.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 12.
DR PROSITE; PS00455; AMP_BINDING; 4.
DR PROSITE; PS50075; CARRIER; 6.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 4.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT DOMAIN 932..1007
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1949..2024
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2980..3054
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3983..4059
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 4908..4982
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 5927..6004
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 1002..1023
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6238..6260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 6260 AA; 666916 MW; 2D8C499E80E87F28 CRC64;
MVHLLPLSPS QRGLWFAQQL NPDIPFTTAQ YVEFRGDLDA DLVRDACNQA AREVESGTLV
LVEQDGKPFQ KVVPDIEDAP RYLDLRSEKD PEAAAHRWMT EQYTKPLDLL SDRLIATTVL
RIADDRYFLS SYVHHIALDG QGAVNMLNRA AELYSAWVSG SEAPPLEAMP IADILDVEAA
YVGSKRQDTD RQHWLERLAD LPESVSFVDH EAPLGVPARR ANSELDADTA AAVSALAHDA
NSTDVPIVLA AFGAFLARTT GVVDVVLSLP VSARTTAALR RSAGVLANVV PLPLCVDPAT
TPAELIRDVQ VELSSTLRHQ RYRYEDMLAD LRSLGRSRDE AASPFGPTVN LMMFHPEIAF
GDVTGEYHHQ SSGPIDDLAV NVYPGVAGRT MRVDFEANPN LYSDEHLSSL HSRFRGFLKE
FVQNAGVAVG DLALADPAEL DGLAPARGRT APEPELLLDV LTRHAASDTV AVVDGNDSIT
YRELDARSDA LAHALVAAGA GPEERVAVLL PRSIDSVVAL WAVAKTGAAY TPLDPELPAR
RLEQVLRDVR IAVAHDHPAL PEHVSRVAPP TDGFGETFTA EHRLRPLHVD NTAWVIHTSG
SSGTPKAVAV GHRGVSALVS TLRDRYRADE TSRVLHLASP SFDASLQELL LAFDAGATLV
ICPPDAVGGP ALATLLRSES VTHAITAPAI LAVTPDDALP DLQVLDAGGE ALPQAVADRW
STGRTMLNAY GPTETTILAT LSDPLQPGAG VPIGRPIDGT TAVVLDARLH PVPAGVIGEL
YLGGPGVARG YLGASAFTAE RFVASPFGGR MYRTGDRARW TTDGHLEFLG RADQQVKIRG
YRIELGEIEA ALVSFDEVQA ATVTVHGEHI AAYVVGDVDP ADLTVRLADE LPTYLRPSSI
TVLEALPLTP GGKVDRRALP APERAVAVGS RPPNGPTEKI VAELFAELTG IDDIGADDDF
FALGGHSLGA AQLAARLGAA LGRDVQLRDV FAHPTVARLA AAAAKRPESE SRPVATPNTG
PSPLAPAQRR LFLLARAHGD PAAYHLPFAL HLDGALDLPA LQAAVMDVLD RHETLRTLFR
LELDGPVQDV LPLERAVAGL ALEPEAAEGD VESLITEWAA EPFDLTAQIP FRIRLLRLAD
DKHVLAVVAH HIALDGASFV PLTADVATAY LARTAGEAPT WMPLPLHYRH YAQWHLDRLG
DPTAPDTRAG REIDYWTSTL DGLADAAPLP TDRPRNGGFG PAAAVDFTVP ADQVAALRSV
AAAHDATTFM AVHAAVAVWL AAWTSGHDIA IGTGTAGRDH PDLDALVGMF VGTVTLRTNV
DPAQPFTALL AQARDTDLDA FAHATVPFDY VVDALGFSPF HVMLAYDNVD VPDLELPGLT
VRPQEIASAQ ARFDLEISLR ELRDGSLTGR LVYDTKLFDD DTIARWVTRL SGVLEQVAQH
PSLPAGDLDL GTLTVEPAEP GPEATFAEII DRSSACVTEP GGQAVEIRTA ARPLAWTLIE
RGIGTEDRVA VVLSRSTRSV LAAAAVALSG AAFVPVDPNQ PAARIAQLLG ASGARYAIVD
GDVALPAGVE PITFTVEGDT RPITDADRVR PLHVDNTAYV VYTSGSTGRP KGVVVSHRGL
GPLAQSFVER FDLPTISDTA TDARVLHFAT PAFDGAVLEY VLALTSGGTL VVAPADLFGG
DELVELLRTE GITHWFSTPS VPTQLDPTGL DALRTIAIGG EAWPVETAER WAPGRTLLNV
YGPTETTVLA TSSEPFAPGD RLTIGTGLVG VTAVVLSERL RPVPEGVTGE LYLGGQGVAR
GYLDAPALTA DRFVANPFGT GRLYRTGDLV RWTGHDDDRA LEFVGRSDHQ VKIRGFRIEL
GEIDATLQTH PGIGTAVTVV RGDTLATYVH SRNGRLDPHE IREWAAQRLP RHMVPAIVTV
LDAFPLTSTG KIDRTALPEP VVTATRTDGY RSATEELVAG VVADLLDLPS VAGSDDFFAV
GGNSLLATQL AARLRGVAGR RVGVRDIFEH PTVAELANLL AEEPTGEHLP LVHIDDDSDA
PLAPAQQRMW LLNRFDVADG IDGGDHIAFA LDLDADTDLD AVRAAAATVL SRHDSLRTVF
PDSPSGPRQH VLPSVTLDLE PVDAGADFDA ELVEFARARF DLTVDPPIRT RLYRTNSGYV
LAVVIDHIAA DGLSLLPLGR DAVAAYRAHR DGETPDLPAP AVTYRDYARW HRAVLGDEND
PDSLAARQLA FWKQTLDDAS PLLALPTDRP RSVATTGTAG RASFTIPAEL HAAIDKLARA
HDVTPFMVMH AAFAILLSAL AATDDVTIGT PVSGRSDAAV DDVVGMFVGT VPLRLRVHPR
RTFADLLADT RRADLDAFAH ADVPFDRIVD AVGAGTDAHH PLFQVILAYE SFSLDEFTLP
GSSTTIREIP VGTARVDLEL TVRERRSETG VPAGLETVLT YADELFDSHT IVQWQSWFVR
ILDAVTADPA VSVGGIELGD ADLTPVGVAQ QLSAESLPEL VAQRVADDPA AVAVVGDGYS
LSYGALWSRS GALAKLLRER GVTAEDVVAV ALPRTPGLVV AILAVSRAGG IYLPVDVTHP
ATRLQALFDD AQPSLVVTDS DFTDVRVPTL RLDDPEVAGR LDDGALFDFP LVADLGAYIV
YTSGSTGTPK GVQVTHRNVL SLLAATVDEF GLRADDVWTL FHSPAFDFSV WEMWAPLATG
ASVVVVDHLT VRDPAAFVDV LTSNRVTVLN QTPTAFYQLA ATDHAPLEDL RLLIFGGEAL
DPERVRPWAE RHPHVRAVNM FGITETTVHV TFGDATATGI GAPLPGLAVD VLDSSLRPAL
PGAIGELYVR GDQLARGYRG RPGQTATRFV AAPGGTRRYR TGDLGRRDTS GALHYLGRAD
QQIELRGYRI EPGEIEAALL RSEGVRQAVV LLRDDRLVAY LVGGDATAAL RDLRRSLPDY
LVPSAAVALD ALPLTVNGKL DRAALPTPDV TAGGGAAPHG PVEELVADVC AELLGIAPGT
LGADDDFFHL GGNSLLATRL AGRLSDVLDT DVTVRDIFEI RTIAALTSHI TSGSDKPARR
ARLVADPDAP APLSAAQQRL WFINRFDPAS PSYNLPFAVR LDGNLDVDAL TAAVADVLER
HRTLRTVYPA ADEYTVLPPA RPDLDPVAVP EDALDEFVRD YATTGFDLTV EPPARMRLYR
TAPDRHVLLV VLHHIAADGW SLTPLLRDIA VAYDARLAGA TPELPALPVQ YTDYARWQRS
VADEQIPYWL GELADLPDEV TLPGDRPRPA QPTGHGAAHT VSLDADLVRG LHELAREGRA
TVFMVLHAAL AALLARHGAG RDIPIGTAVS GRGDPQLDDV VGMFAGTLVL RTDVDPDATF
TELLTQVHRR DLAAYGNPDA PFETLVEKLQ PARSEARHPL FQIALSQARP VASTFTLPGL
NVTAAPVDTE TVNVDVQVTV TEQQDGIDLE FFYSTDLYDA DTVAGYADRL RTILSAAVAD
PDVRVGEIDL HGDAGLPTVG AVPGAPRSLR QWLAQGAAAG GEELAIVDGD RELSYPELLY
YSDALAARLQ LAGVRPGDPV ACAYPRSLES VLAVWGIIGA GAAPMLVDPT APTTRLGEML
ADVHVGVGEA PTLPATVRWL EVTSDDEEPL ADVVDPAPDA PAYFVFTSGT TGHPKAVTVT
QRAASAFAED IGEYLAAFPG DRVLHVAAPS FDAAMLEMLT AGISGATLVV ADADSYGGAA
LGDLLDSAAI THAVMTPSTL ATVPVRDLPA LRTLVLGGDR LTREIVDRWG DGRTLVNSYG
PAEATMFVTN SQPLRPGDDI VIGTPVRGVT VEVLDERLRP VPAGVVGELY VSGPRLASGY
RDAAARTAAR FVAGPDGRRY RTGDLVRWTR AGALEFVGRS DNQIKLRGVR IEPGEIDTAL
TALDGVERAV TLVRGGRLIS YVTGSYVTGE NLDDSDLRAQ LRTVLPAHLV PTAIVPLAAI
PLTSHGKVDA AALPEPAAGE GSEPRTETEA LVARIIGDVL GDGTALGRTD DFFAVGGNSL
LATVLVGRLR DETGTDVPLR TVFANPTVDA LAAALDAGGF DTDAGPVAVS PRPERIPLSR
AQRRLWGLSS LAPDAYRLRS EVNLSGPLDL GALQAALGDV ALRHEILRTD YIVDGDGVYQ
QVHEAPRSDR WRVRLERTGP DQHVLYLDVD HSIADGTSLR PLLRDLTIAY LARVNGAAPK
WEPLPLQYAD YALWEAERGI PERDLEHWRR ALDGLTVTEL PADATGIDTG ARSVDFTVPA
DVRDALADLA RAHGATEFMV LHAALSVLLA RLGGSDDIAV AAVVGGRRWA QLEDLVGPFL
DTLVLRARVA PDMSFAGLLG QVRDFDVAAF DHVAVPYEQL LSERQSGAPQ VALALQDFGI
NPISLGELTV EAHEVLDDTP KFDLQFTLAP RPDGYTGTLV FDAARFAGRT AELLVTRFVA
LLGSLASAPD RTIGEVVVDA PAAALDGGEP ATAHTLAEML RATAAAHPDR EALRGAGESL
TYRELDEQSD ALAEELRADG ARDGKIVRID APRSVDYIRT LWAITKTGAA FTHSRQAGET
CLPGTAYVVS TSGSTGTPKR VAVTHRGLAP LAAEAAERYR VEPGDRVLHG YSPEFDAALL
ELLLAHTTGA TLVVAPPDVY AGQDLHRYLA EQRITHYLST PTVLGTLDPE GLPDLKVVAS
GGESLSSSLA ARWADGRVML DAYGPTEATI VATLVDIEPG TRPSIGKPVP GTVAHVLDAR
LRPVPAGAVG ELYLAGEGLA AGYLDDPART AERFVAAPGG ARMYRTGDRV HRRVDDTLGY
LGRTDRQLKV RGVRIEPGEL EATLLAQPGI RQAAVVAVSG TLVAFAAGPD LSADDITARL
ALVVPPHRMP TRVHVLDQLP LTPNGKLDVA ALELHDAAAL DDDAALDRPL TDAEDLVVTV
AEDVLGARPA AHRGFFTAGG DSLSAVVFAA RLSETFGTDV PVREVLAAPT LAVLAARIES
GDDQRVALRH YDDDTPAPIA PAQRRLGIVA RSETGTAGYL VPVVLTLSGD LDVDALTAAV
SDVVDRHRVL RTAFTDDMQV PVDPPVLEHS APEDVAAAVT ATITTPFDIT TQAPMRIRLF
DVEPGRWVLA AAVHHIAFDG ASVGPLLTDL AVAYAARRGT EAPVFESLPV TYGDYARWQH
ELLGDATDPS SVAARQLDYW TTTLAGLPDS PLPLPADRPR PAQPTHRGAQ VVSTLDAETH
RRLRDVARSH DVTVFMLVHA VLAAMLARRS GRTDIAVGTA IAGRTDARLD RLVGMFVGTV
VLRTAVDSSR PFTDLLRDVR ATDLGALAHA DVPFDEVVAR LAPRRDPSYS PLFQVLLTHR
VEAGEVLPQL PDVQIAETDA GEPAAQFDVV VELVEREAGL DLRLVYATDL FDDTTGDAML
TDLVAMLAAA LAEPDRAVGD LAVPVPAPLS TAAVPPRILP EILETAVEQY RGRIAVRSGT
VAWTYGGLDA RADEIASVLT SHGVRRGDLV AIAVPRSEYW PLAVWAITKL GAAWVSVDLT
QPDARSAAIL ADSGARIGLT VGYRELGHVT WLDLTADRSI DFDAVEPPRP AVTSDDLAYT
IYTSGTTGTP KGVDVTHRGL AALLDVQTAL LDLGPESRVL QVASHTFDAA VFELLSAHAH
GGALVIAPDH TFAGEPLQEL IVDERVTHLN LTPTVLGTLD PEAFEPMTIV AAGETLPGAL
VGRWSRHRIV NGYGPTEFTV AVSYSAPLTG HEKPSIGVPV AGATAYVLDS RLHPVPRGTV
GELYVTGDST ARGYRYESGL TATRFVANPF GHGGSRLYRT GDLVRILPNG VLDHVARIDD
QVKIHGIRIE PAEVDAALLN RPGVAAAVTV PHPGRDGDTV LVSYIQPETG TAPDTAALRR
ALVADLPRHL RPVSITVVDA LPLMASGKVD RAALPAPDTA VDEPYVAPQG HIAQTVAAVF
ARHLDRPIDE ISADRSFFDL GGSSIAAVTV AGELRDELGA DVPVEWLFTS PDLASLAGRI
DHGRSNDERD PLGSLVEIAG RGDEKPPLFC VHPISGLAWM YAGFAQHLDG RTLYGLQATG
FDDIPDSIGE LAARYVAEIR KVRADGPYHL LGWSVGGTIA HEMAVQLREH GEQVGAVVLL
DTLTPETVPA EPHPTAENVP DIAGLPEELV AEVRRRTDAA AQAVEDAVRR HTLSEYDGDI
DLVVAEPDLD RHPDIAATWQ RYVRGLVVEH PVPFTHSELA DPDAVRAIGP VLDSVLERHD
DPHTAPAGCA RSVTATRETP
//
