ID VAX2_RAT Reviewed; 292 AA.
AC Q9JLZ9;
DT 26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 27-MAR-2024, entry version 117.
DE RecName: Full=Ventral anterior homeobox 2;
GN Name=Vax2;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley; TISSUE=Schwann cell;
RA Bertuzzi S., Mui S.H., Lemke G.;
RT "Rat Vax2: a novel member of the Vax homeobox gene subfamily.";
RL Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Transcription factor that may function in dorsoventral
CC specification of the forebrain. Regulates the expression of Wnt
CC signaling antagonists including the expression of a truncated TCF7L2
CC isoform that cannot bind CTNNB1 and acts therefore as a potent
CC dominant-negative Wnt antagonist. Plays a crucial role in eye
CC development and, in particular, in the specification of the ventral
CC optic vesicle (By similarity). May be a regulator of axial polarization
CC in the retina. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the EMX homeobox family. {ECO:0000305}.
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DR EMBL; AF113516; AAF25691.1; -; mRNA.
DR RefSeq; NP_072159.1; NM_022637.1.
DR AlphaFoldDB; Q9JLZ9; -.
DR SMR; Q9JLZ9; -.
DR STRING; 10116.ENSRNOP00000018128; -.
DR PhosphoSitePlus; Q9JLZ9; -.
DR PaxDb; 10116-ENSRNOP00000018128; -.
DR GeneID; 64572; -.
DR KEGG; rno:64572; -.
DR UCSC; RGD:621133; rat.
DR AGR; RGD:621133; -.
DR CTD; 25806; -.
DR RGD; 621133; Vax2.
DR eggNOG; KOG0843; Eukaryota.
DR InParanoid; Q9JLZ9; -.
DR OrthoDB; 903523at2759; -.
DR PhylomeDB; Q9JLZ9; -.
DR PRO; PR:Q9JLZ9; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR GO; GO:0005634; C:nucleus; ISO:RGD.
DR GO; GO:0031490; F:chromatin DNA binding; ISO:RGD.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; ISO:RGD.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0001162; F:RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding; ISO:RGD.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:RGD.
DR GO; GO:0007409; P:axonogenesis; ISO:RGD.
DR GO; GO:0007420; P:brain development; IBA:GO_Central.
DR GO; GO:0043010; P:camera-type eye development; ISO:RGD.
DR GO; GO:0008283; P:cell population proliferation; IEA:UniProt.
DR GO; GO:0007417; P:central nervous system development; IBA:GO_Central.
DR GO; GO:0009950; P:dorsal/ventral axis specification; ISO:RGD.
DR GO; GO:0048048; P:embryonic eye morphogenesis; ISO:RGD.
DR GO; GO:0030900; P:forebrain development; ISS:UniProtKB.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISO:RGD.
DR GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0060041; P:retina development in camera-type eye; ISO:RGD.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR InterPro; IPR000047; HTH_motif.
DR PANTHER; PTHR24339; HOMEOBOX PROTEIN EMX-RELATED; 1.
DR PANTHER; PTHR24339:SF34; VENTRAL ANTERIOR HOMEOBOX 2; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR PRINTS; PR00031; HTHREPRESSR.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation; Wnt signaling pathway.
FT CHAIN 1..292
FT /note="Ventral anterior homeobox 2"
FT /id="PRO_0000049353"
FT DNA_BIND 102..161
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..74
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 212..241
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..39
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 42..67
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 218..235
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 292 AA; 31706 MW; 5D1C12BB470682A5 CRC64;
MGDGGAERDR GPKRREEPGG RSGCRGEHRG AEDLRADTGS TSPREIAGTS ASSPAGSRES
GGDSDGQQAL GETDHCRRIL VRDAKGTIRE IVLPKGLDLD RPKRTRTSFT AEQLYRLEME
FQRCQYVVGR ERTELARQLN LSETQVKVWF QNRRTKQKKD QSRDLEKRAS SSAFEAFATS
NVLRLLEQGR LLSVPRAPSL LALSPGLPGL TAGHRGTSLG DPRNSSQRLN PMPSASASSP
LPPPLPAVCF SAAPLLDLPA SYKLGSSAFE PYSRLEQQKV GSPGQSDKKA DI
//
