ID VPS10_ARTOC Reviewed; 1465 AA.
AC C5FYX2;
DT 03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 03-MAY-2011, sequence version 2.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=Vacuolar protein sorting/targeting protein 10;
DE AltName: Full=Carboxypeptidase Y receptor;
DE Short=CPY receptor;
DE AltName: Full=Sortilin VPS10;
DE AltName: Full=Vacuolar carboxypeptidase sorting receptor VPS10;
DE Flags: Precursor;
GN Name=VPS10; ORFNames=MCYG_07539;
OS Arthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Arthrodermataceae; Microsporum.
OX NCBI_TaxID=554155;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4605 / CBS 113480;
RX PubMed=22951933; DOI=10.1128/mbio.00259-12;
RA Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W.,
RA Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E.,
RA Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I.,
RA Rossi A., Saif S., Samalova M., Saunders C.W., Shea T., Summerbell R.C.,
RA Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.;
RT "Comparative genome analysis of Trichophyton rubrum and related
RT dermatophytes reveals candidate genes involved in infection.";
RL MBio 3:E259-E259(2012).
CC -!- FUNCTION: Functions as a sorting receptor in the Golgi compartment
CC required for the intracellular sorting and delivery of soluble vacuolar
CC proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes
CC multiple rounds of sorting by cycling between the late Golgi and a
CC prevacuolar endosome-like compartment (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Prevacuolar
CC compartment membrane {ECO:0000250}; Multi-pass membrane protein
CC {ECO:0000250}. Note=Cycles between the Golgi apparatus and the
CC prevacuolar compartment. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the VPS10-related sortilin family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EEQ34720.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DS995707; EEQ34720.1; ALT_SEQ; Genomic_DNA.
DR RefSeq; XP_002843756.1; XM_002843710.1.
DR AlphaFoldDB; C5FYX2; -.
DR SMR; C5FYX2; -.
DR STRING; 554155.C5FYX2; -.
DR GlyCosmos; C5FYX2; 3 sites, No reported glycans.
DR GeneID; 9226444; -.
DR eggNOG; KOG3511; Eukaryota.
DR HOGENOM; CLU_000700_0_0_1; -.
DR OrthoDB; 5840at2759; -.
DR Proteomes; UP000002035; Unassembled WGS sequence.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0007034; P:vacuolar transport; IEA:UniProt.
DR CDD; cd15482; Sialidase_non-viral; 1.
DR Gene3D; 2.10.70.80; -; 2.
DR Gene3D; 3.30.60.270; -; 2.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR12106; SORTILIN RELATED; 1.
DR PANTHER; PTHR12106:SF27; VPS10 HOMOLOG 1-RELATED; 1.
DR Pfam; PF15902; Sortilin-Vps10; 2.
DR Pfam; PF15901; Sortilin_C; 2.
DR SMART; SM00602; VPS10; 2.
DR SUPFAM; SSF110296; Oligoxyloglucan reducing end-specific cellobiohydrolase; 2.
PE 3: Inferred from homology;
KW Glycoprotein; Golgi apparatus; Membrane; Protein transport; Receptor;
KW Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix;
KW Transport.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..1465
FT /note="Vacuolar protein sorting/targeting protein 10"
FT /id="PRO_0000407501"
FT TOPO_DOM 24..1336
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 1337..1357
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1358..1383
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 1384..1404
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1405..1465
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT REPEAT 374..383
FT /note="BNR 1"
FT REPEAT 434..444
FT /note="BNR 2"
FT REPEAT 481..491
FT /note="BNR 3"
FT REPEAT 700..709
FT /note="BNR 4"
FT REPEAT 1082..1092
FT /note="BNR 5"
FT REPEAT 1124..1133
FT /note="BNR 6"
FT CARBOHYD 293
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 882
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 947
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1465 AA; 164786 MW; D047E2E72DACAFDD CRC64;
MIIRSILLAG SLLLASAIPG TLAKSDEPEI KVKELDKVPT SIYYFEDTDT IIFQKGLGEI
YISTDAASSW EVMKDKTGLL WLNRHHTQSA CIVGDKRKHW VTYDAAKTWR EFEVPDKLIL
GERIQPFVFH GKDSNKAIIN AEECLLTGCR RVTYYTVDGF KTIKKLLQDD SGCYWAVGHP
NVGEGLDIRK KIDDRIFCIL PGALPFNSSP RLVYSDKFFS DDMAIPVEIN GRELRGINKF
AFVKKFLVIA TVSDGTSEAA IYVSRDAMHW DRAEFYGGPK VREGKFTFLE STNYSIQVNV
ASRRSKLPIG SLYTSDSTGT SFTMNVDSVN EDKDMYTDFE QVSGIQGIFL INRVDNAEEV
KTGKASEKKI VSRISFDDGR TFKPLKYKDK EIHLHSITRP SNSGRTFSSP APGLVMGVGN
SGDRLKEYEH GNLYVSDDAG ITWRKALDKA HKYEFGDQGS LLVAIFDEAG GDKIYTDEIS
YSLNHGKDWK KVKLPHTFLL LAEDKNKKFY VMSIDFSGLH ERKCGKNDFE RWAARLDEKG
EPDCLMGHKQ FYRRRKADAD CFVKEKFKEP LPEIEPCKCT KEDFECAAGF KRNNDYDCEP
DGKLKPSEGQ CKKPDDKFMG PSGYRLIPGD DCIKKGGVDL EKEVERACKE TSKGPISGKI
AVEATPFETE GFQYRYLERS DTSSGDDETV IFKTDKGEIF VSKDHGKSWG RGKFKEPILE
FMPHKYDKDV IYLLTGSKKA YWSIDRGHSF HAFEAKMPFT RTLGSLPLFF HPDRPDWLIW
IGGEGCSGKK CNDVAYYSKN RGDEWELLLR GVNKCMFVGK EGELTNDDLI FCSQHEGEDP
HKDMRLVSSD TMFSKKTSIH FDGKPIAGFT KMSEFIVVAT KNGSELQSFT SVDGKTFAHA
AFPPNFHVDF EHAYTVLDSS THSVFLHVTE HAARGHEFGS ILKSNSNGTS YVLSLNGANR
NVKDYVDFEK IQVVEGVALG NVVFNTEEVK KKNEEKKFRS MITHNDASEW ALLPPPKKDV
DGHSFGCKVT DKGTNDCALH LHGYTERRDN RDSMSSGSAV GLIIGVGNVG SHLTARAESD
TFMSRDAGIT WHQIRKGRYQ WEFGDQGSII VIVAEGKPTK VLSYTLDEGE TWTDFEFTDA
EVTVEDISTV PSDTSKNFLL WTKKGSTTDL VVYNIDFSGL KERERQCVLK KDAPEADDYY
LWSPKHPMQK DNCLFGHVSL YHRKKPDAKC YNGPRLDRLS SEKKNCECTR QDYECDYNYE
RQTDGSCALV KGLKPADPMQ ICKADPDAVE YFEPTGYRKL PVSTCEGGVQ LDHIVARPCP
NKKKEFEKKH PGISGLGLFL AIFFPLATAA AVGYWAFSKW DGKFGRIRLG ESQPESIFSG
DSPLIAIPVT IVAGTVAVIT ALPLLFSSLW RSVRGYTRLP GRWRQRPYAS RGAFAARRGD
YVGVVDDEDE LLGAEEFEGD EEDEV
//
