ID VPS10_TALSN Reviewed; 1502 AA.
AC B8MG72;
DT 03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 03-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=Vacuolar protein sorting/targeting protein 10;
DE AltName: Full=Carboxypeptidase Y receptor;
DE Short=CPY receptor;
DE AltName: Full=Sortilin vps10;
DE AltName: Full=Vacuolar carboxypeptidase sorting receptor vps10;
DE Flags: Precursor;
GN Name=vps10; ORFNames=TSTA_010560;
OS Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL
OS 1006) (Penicillium stipitatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Trichocomaceae; Talaromyces;
OC Talaromyces sect. Talaromyces.
OX NCBI_TaxID=441959;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006;
RX PubMed=25676766; DOI=10.1128/genomea.01559-14;
RA Nierman W.C., Fedorova-Abrams N.D., Andrianopoulos A.;
RT "Genome sequence of the AIDS-associated pathogen Penicillium marneffei
RT (ATCC18224) and its near taxonomic relative Talaromyces stipitatus
RT (ATCC10500).";
RL Genome Announc. 3:E0155914-E0155914(2015).
CC -!- FUNCTION: Functions as a sorting receptor in the Golgi compartment
CC required for the intracellular sorting and delivery of soluble vacuolar
CC proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes
CC multiple rounds of sorting by cycling between the late Golgi and a
CC prevacuolar endosome-like compartment (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Prevacuolar
CC compartment membrane {ECO:0000250}; Multi-pass membrane protein
CC {ECO:0000250}. Note=Cycles between the Golgi apparatus and the
CC prevacuolar compartment. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the VPS10-related sortilin family.
CC {ECO:0000305}.
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DR EMBL; EQ962656; EED15939.1; -; Genomic_DNA.
DR RefSeq; XP_002483173.1; XM_002483128.1.
DR AlphaFoldDB; B8MG72; -.
DR SMR; B8MG72; -.
DR STRING; 441959.B8MG72; -.
DR GlyCosmos; B8MG72; 4 sites, No reported glycans.
DR GeneID; 8109829; -.
DR VEuPathDB; FungiDB:TSTA_010560; -.
DR eggNOG; KOG3511; Eukaryota.
DR HOGENOM; CLU_000700_0_0_1; -.
DR InParanoid; B8MG72; -.
DR OMA; ATMSEFI; -.
DR OrthoDB; 5840at2759; -.
DR PhylomeDB; B8MG72; -.
DR Proteomes; UP000001745; Unassembled WGS sequence.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0007034; P:vacuolar transport; IEA:UniProt.
DR CDD; cd15482; Sialidase_non-viral; 2.
DR Gene3D; 2.10.70.80; -; 2.
DR Gene3D; 3.30.60.270; -; 2.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR12106; SORTILIN RELATED; 1.
DR PANTHER; PTHR12106:SF27; VPS10 HOMOLOG 1-RELATED; 1.
DR Pfam; PF15902; Sortilin-Vps10; 2.
DR Pfam; PF15901; Sortilin_C; 2.
DR SMART; SM00602; VPS10; 2.
DR SUPFAM; SSF110296; Oligoxyloglucan reducing end-specific cellobiohydrolase; 2.
PE 3: Inferred from homology;
KW Glycoprotein; Golgi apparatus; Membrane; Protein transport; Receptor;
KW Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix;
KW Transport.
FT SIGNAL 1..29
FT /evidence="ECO:0000255"
FT CHAIN 30..1502
FT /note="Vacuolar protein sorting/targeting protein 10"
FT /id="PRO_0000407537"
FT TOPO_DOM 30..1369
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 1370..1390
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1391..1422
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 1423..1443
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1444..1502
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT REPEAT 68..78
FT /note="BNR 1"
FT REPEAT 120..130
FT /note="BNR 2"
FT REPEAT 395..404
FT /note="BNR 3"
FT REPEAT 456..466
FT /note="BNR 4"
FT REPEAT 498..508
FT /note="BNR 5"
FT REPEAT 740..750
FT /note="BNR 6"
FT REPEAT 1119..1129
FT /note="BNR 7"
FT REPEAT 1160..1171
FT /note="BNR 8"
FT CARBOHYD 314
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 339
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 985
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1280
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1502 AA; 168336 MW; 76611BEB0DF5A979 CRC64;
MIRQCLHLTT SPLLLLLLIA LSSIGTVVAK SDGPKIASIQ LETEPSMPFY FENSDTVLFL
RLDTGEVYQS FDGGVEWKVL GKDHETEGET AGLANGAVMI QAHPYDNQKA YILGRHGVHW
VTTDQGKTWR EFEVPAAPSM FNEPLRFHGE DSGKVIFQGE RCSAFACVET SYYTRNNFET
VKPMRDTARG CMWAVATPGF ADSTTEHAEE IRDRVLCIVH GLKNPFASAY RLVYSDSFFE
DDQDGIEAKL NEGRPVAGII NAAARTKYIV AAAKSQGTDE LAMFVTDDAI TWHRAEFGNH
KIEESAYTVL EGTNYSIEVD VMNTDRSTNM GVLFTSNSNG TYFTRNIEHT NRDMSGLVDF
EKIAGVQGIV LVNVVDNWEE IENDPKADRK VISKISFDDG RTFQSLKVKD KDLHLHSVTA
FENIGRVFSS PAPGIVMGVG NTGTHLKSYT KDGDLYVSDD AGVTWRLALE KPHKYEIGNK
GAIIMAIKDN DKPTKKIQYS INHGKDWETA ELDREIIPYF LTTTPDSTSL KFMLVGYVED
PADWYIYAID FEGLHERECK DSDFENWPAR LDENGEPDCL MGHKQFYRRR KSDANCFITE
TMFKTPKPEF KSCKCTAEDF ECDYNFVRSE DRKECVPATI LKAPEGTCKN DDDTFKGPSG
WRLIPGNVCT RDGAVELDKE IDRPCKDALK TPSGDSKAVS STANYIETEM FGEFFYLERA
GSSRGEDETI IMRTTDGKLY VTHDHGKSWT HELKDVKIQQ IAPHRYLNDR AFFLTSGKKQ
YYTINRAESF DAFSAPAEVN PSGLTLGYHE EFKDWMIWTG PGECSHGECP KVSFISKHRG
DDWEILLRAV EKCEFMARED RKDSGSLIFC DQHEGEKVDG QRMLVTSNDF FATSTTPLTN
IIDFATMAEF IIIATRNPEK ENSLKVDASV NGVEFADAEF PYNLEVPVQL AYTVLDSSTH
SVFLHVTANN KMDQSYGSII KSNSNGTSYV LSLNDVNRNN GGYVDFEKLP GLEGVALANV
VSNTKNVEKG SEKKLTSMIT HNDGSQWTLI PPPAKDSEGK PYSCGSDGKP TDKCSLHLHG
YTERRDPRDS FGSASAIGLL FGVGNVGESL GSKSEASTFF SSDGGISWKE VKKGNYMWKF
GDQGSVLVLV EELKPTRDIY FSTDEGDTWE KYQFSEKEVT VQSLSTVPSG TSKNFLIWGK
ETGSSKLVTI NLDFSGLRDR TCNLDEDTGE SEDYYLWEPK HPLQEGNCLF GHVEQYHRKK
PSSHCWNDWS EAHVHRISHN CTCTEEDYEC DYNYERQTDG SCALVPGLLK PNAIDYCREN
PEAIEYWEPT GYRRIPLTTC QGGKNLDRWV SRPCPSHEEE YQRKHGPSGA VIFFAIIVPI
TIAVAAGYWV YTRWDGKFGQ IRLGDGGAQS FVTSRGDSPF ITIPVAIIAG TVAAVKVLPL
LVMSLWRSVT GYVRIPGRRG PRPYATRDAF AARRGDYTHV VDDEDELLGD DEFEDEEGDE
RN
//
