ID VPS28_CAEBR Reviewed; 209 AA.
AC A8XWB7;
DT 15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 1.
DT 24-JAN-2024, entry version 72.
DE RecName: Full=Vacuolar protein sorting-associated protein 28 homolog {ECO:0000250|UniProtKB:Q9NA26};
DE AltName: Full=ESCRT-I complex subunit VPS28 {ECO:0000250|UniProtKB:Q9NA26};
GN Name=vps-28 {ECO:0000312|EMBL:CAP36936.1}; ORFNames=CBG19782;
OS Caenorhabditis briggsae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6238;
RN [1] {ECO:0000312|EMBL:CAP36936.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF16;
RX PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA Durbin R.M., Waterston R.H.;
RT "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT genomics.";
RL PLoS Biol. 1:166-192(2003).
CC -!- FUNCTION: Component of the ESCRT-I complex, a regulator of vesicular
CC trafficking process. {ECO:0000250|UniProtKB:Q9NA26}.
CC -!- SUBUNIT: Component of the ESCRT-I complex (endosomal sorting complex
CC required for transport I). {ECO:0000250|UniProtKB:Q9NA26}.
CC -!- SUBCELLULAR LOCATION: Endosome {ECO:0000250|UniProtKB:Q02767}.
CC -!- SIMILARITY: Belongs to the VPS28 family. {ECO:0000255|PROSITE-
CC ProRule:PRU00642, ECO:0000255|PROSITE-ProRule:PRU00645}.
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DR EMBL; HE601474; CAP36936.1; -; Genomic_DNA.
DR RefSeq; XP_002640715.1; XM_002640669.1.
DR AlphaFoldDB; A8XWB7; -.
DR SMR; A8XWB7; -.
DR STRING; 6238.A8XWB7; -.
DR EnsemblMetazoa; CBG19782.1; CBG19782.1; WBGene00038947.
DR GeneID; 8582710; -.
DR KEGG; cbr:CBG_19782; -.
DR CTD; 8582710; -.
DR WormBase; CBG19782; CBP19690; WBGene00038947; Cbr-vps-28.
DR eggNOG; KOG3284; Eukaryota.
DR HOGENOM; CLU_076417_2_0_1; -.
DR InParanoid; A8XWB7; -.
DR OMA; CDEFPTV; -.
DR OrthoDB; 5486880at2759; -.
DR Proteomes; UP000008549; Chromosome I.
DR GO; GO:0000813; C:ESCRT I complex; IBA:GO_Central.
DR GO; GO:0044877; F:protein-containing complex binding; IBA:GO_Central.
DR GO; GO:0043328; P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; IBA:GO_Central.
DR GO; GO:0032801; P:receptor catabolic process; IEA:EnsemblMetazoa.
DR Gene3D; 1.20.120.1130; -; 1.
DR Gene3D; 1.20.1440.200; -; 1.
DR InterPro; IPR037202; ESCRT_assembly_dom.
DR InterPro; IPR007143; Vps28.
DR InterPro; IPR017899; VPS28_C.
DR InterPro; IPR037206; VPS28_C_sf.
DR InterPro; IPR017898; VPS28_N.
DR InterPro; IPR038358; VPS28_N_sf.
DR PANTHER; PTHR12937; VACUOLAR PROTEIN SORTING 28, ISOFORM 2 VPS28; 1.
DR PANTHER; PTHR12937:SF0; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 28 HOMOLOG; 1.
DR Pfam; PF03997; VPS28; 1.
DR PIRSF; PIRSF017535; VPS28; 1.
DR SUPFAM; SSF140111; Endosomal sorting complex assembly domain; 1.
DR SUPFAM; SSF140427; VPS28 C-terminal domain-like; 1.
DR PROSITE; PS51310; VPS28_C; 1.
DR PROSITE; PS51313; VPS28_N; 1.
PE 3: Inferred from homology;
KW Endosome; Protein transport; Reference proteome; Transport.
FT CHAIN 1..209
FT /note="Vacuolar protein sorting-associated protein 28
FT homolog"
FT /id="PRO_0000394401"
FT DOMAIN 1..105
FT /note="VPS28 N-terminal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00645"
FT DOMAIN 109..205
FT /note="VPS28 C-terminal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00642"
SQ SEQUENCE 209 AA; 24268 MW; 5D685D78097D9851 CRC64;
MSQNSNLMRE VRLFENHSER EQMENLSELF AVLNALEHLE KMFSRDHVTA DEYKTECFKL
IDQYKVTMRL VHGATSIEEF AKKYRLHCPA AIERIREGRP ITVKDDQGNV LKHIASIVEQ
FITFLDSLRL NTRAVDDLYP VLDDLYNAIN STSRVPIDAN VTTKVKKWHD RLSSMAATDE
ISDDEARQMI FDTEGAYQSF QKALNEQKH
//
