ID VSIG1_BOVIN Reviewed; 382 AA.
AC Q29RR6;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 04-APR-2006, sequence version 1.
DT 24-JAN-2024, entry version 85.
DE RecName: Full=V-set and immunoglobulin domain-containing protein 1;
DE Flags: Precursor;
GN Name=VSIG1;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Testis;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
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DR EMBL; BC114057; AAI14058.1; -; mRNA.
DR RefSeq; NP_001039395.1; NM_001045930.2.
DR AlphaFoldDB; Q29RR6; -.
DR SMR; Q29RR6; -.
DR STRING; 9913.ENSBTAP00000074553; -.
DR GlyCosmos; Q29RR6; 3 sites, No reported glycans.
DR PaxDb; 9913-ENSBTAP00000010335; -.
DR GeneID; 505937; -.
DR KEGG; bta:505937; -.
DR CTD; 340547; -.
DR eggNOG; ENOG502QU0R; Eukaryota.
DR InParanoid; Q29RR6; -.
DR OrthoDB; 3024056at2759; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0016323; C:basolateral plasma membrane; IBA:GO_Central.
DR GO; GO:0003382; P:epithelial cell morphogenesis; IEA:InterPro.
DR GO; GO:0030277; P:maintenance of gastrointestinal epithelium; IBA:GO_Central.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR029861; VSIG1.
DR PANTHER; PTHR44974; V-SET AND IMMUNOGLOBULIN DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR44974:SF1; V-SET AND IMMUNOGLOBULIN DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF13927; Ig_3; 1.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 2.
DR SMART; SM00408; IGc2; 2.
DR SMART; SM00406; IGv; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR PROSITE; PS50835; IG_LIKE; 2.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane;
KW Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..382
FT /note="V-set and immunoglobulin domain-containing protein
FT 1"
FT /id="PRO_0000313572"
FT TOPO_DOM 22..234
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 235..255
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 256..382
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 22..133
FT /note="Ig-like V-type"
FT DOMAIN 140..227
FT /note="Ig-like C2-type"
FT REGION 266..382
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 321..341
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 32
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 200
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 219
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 43..116
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 161..211
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ SEQUENCE 382 AA; 41657 MW; 34590C2D574C66E7 CRC64;
MGLTFWKVFL ILNCLAGQVN GVQVTIPDSF VNVTVGSDVT LICTYATTVA SLNKLSIQWT
FFHKEASQPV SIYYSEGGQA TAIGKFKDRI VGSNTSGNAS ITISHMQPED SGIYICDVNN
PTDFFGKNQG TISVSVLVKP SKPFCSIQGI AETGHPISLT CLSVLGTPSP VYYWYKLEGR
NIVPVKENFN PATGILFIGN LTTFEQGYYQ CTAINILGNS SCEIDLTTPY PGIGIIVGAF
VGTLIGVIII ISVVWFVRRK VKAKGKERKR NSKTTTELEP MTKINQRTEG ETMPREDAIQ
LEATLPSSTH ETEPNATLGP DHEPIPEPEP ALQPTVEPPS GPELVPMSEL EIQLEPEPAP
QQEPEPLIVD EPFCDEEKVI KP
//
