ID W0E519_MARPU Unreviewed; 224 AA.
AC W0E519;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE RecName: Full=pre-crRNA processing endonuclease {ECO:0000256|PIRNR:PIRNR029950};
DE EC=3.1.-.- {ECO:0000256|PIRNR:PIRNR029950};
GN ORFNames=MARPU_12880 {ECO:0000313|EMBL:AHF04638.1};
OS Marichromatium purpuratum 984.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Chromatiales; Chromatiaceae;
OC Marichromatium.
OX NCBI_TaxID=765910 {ECO:0000313|EMBL:AHF04638.1, ECO:0000313|Proteomes:UP000005275};
RN [1] {ECO:0000313|EMBL:AHF04638.1, ECO:0000313|Proteomes:UP000005275}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=984 {ECO:0000313|EMBL:AHF04638.1,
RC ECO:0000313|Proteomes:UP000005275};
RG DOE Joint Genome Institute;
RA Bryant D.A., Huntemann M., Han J., Chen A., Kyrpides N., Mavromatis K.,
RA Markowitz V., Palaniappan K., Ivanova N., Schaumberg A., Pati A.,
RA Liolios K., Nordberg H.P., Cantor M.N., Hua S.X., Woyke T.;
RL Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: CRISPR (clustered regularly interspaced short palindromic
CC repeat) is an adaptive immune system that provides protection against
CC mobile genetic elements (viruses, transposable elements and conjugative
CC plasmids). CRISPR clusters contain spacers, sequences complementary to
CC antecedent mobile elements, and target invading nucleic acids. CRISPR
CC clusters are transcribed and processed into CRISPR RNA (crRNA).
CC {ECO:0000256|PIRNR:PIRNR029950}.
CC -!- SIMILARITY: Belongs to the CRISPR-associated protein Cas5 family.
CC Subtype I-C/Dvulg subfamily. {ECO:0000256|PIRNR:PIRNR029950}.
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DR EMBL; CP007031; AHF04638.1; -; Genomic_DNA.
DR RefSeq; WP_005221616.1; NZ_CP007031.1.
DR AlphaFoldDB; W0E519; -.
DR STRING; 765910.MARPU_12880; -.
DR KEGG; mpur:MARPU_12880; -.
DR eggNOG; ENOG502Z82V; Bacteria.
DR HOGENOM; CLU_086014_0_0_6; -.
DR OrthoDB; 5621871at2; -.
DR Proteomes; UP000005275; Chromosome.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-UniRule.
DR GO; GO:0043571; P:maintenance of CRISPR repeat elements; IEA:UniProtKB-UniRule.
DR CDD; cd09752; Cas5_I-C; 1.
DR Gene3D; 3.30.70.2660; -; 1.
DR InterPro; IPR021124; CRISPR-assoc_prot_Cas5.
DR InterPro; IPR013422; CRISPR-assoc_prot_Cas5_N.
DR InterPro; IPR010155; CRISPR-assoc_prot_Cas5d.
DR NCBIfam; TIGR01876; cas_Cas5d; 1.
DR NCBIfam; TIGR02593; CRISPR_cas5; 1.
DR Pfam; PF09704; Cas_Cas5d; 1.
DR PIRSF; PIRSF029950; Cas_CT1134; 1.
PE 3: Inferred from homology;
KW Antiviral defense {ECO:0000256|ARBA:ARBA00023118,
KW ECO:0000256|PIRNR:PIRNR029950};
KW Endonuclease {ECO:0000256|PIRNR:PIRNR029950};
KW Hydrolase {ECO:0000256|PIRNR:PIRNR029950};
KW Nuclease {ECO:0000256|PIRNR:PIRNR029950};
KW Reference proteome {ECO:0000313|Proteomes:UP000005275};
KW RNA-binding {ECO:0000256|PIRNR:PIRNR029950}.
SQ SEQUENCE 224 AA; 25614 MW; 493BBF4DDE673448 CRC64;
MSFGVRLHVW GERACFTRPE MKVERVSYDI ITPSAARGIL EAIHWKPAIR WHVERIQVLR
PIRFESIRRN EVGGKLSAAT VRKAIKAGTT AGVAKWVEED RQQRAATVLR DVGYVIEAHF
SLTERAGDED NVGKHLDIFN RRARRGQCFH MPCFGVREFP ASFRLLEDDE PFPAVAEALA
GERDLGWMLH DIDFANGMTP RFFRARMIDG RVDVPAWDDT EVRA
//